DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and ctrip

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster

Alignment Length:	1719	Identity:	319/1719 - (18%)
Similarity:	533/1719 - (31%)	Gaps:	671/1719 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 CALPQPSEASLTGSKETREPRHHQTLLSTKSCETPANNATLSPTNSYNGSIGSDGGSSVGGGARR 187
            ||.|.|...|.|.:......       .::|....||:..::|. ..:.:.|....|:....::.
  Fly  1663 CANPSPKPLSATATPTANAG-------GSQSAPASANSLQVNPF-FMDSAPGLSSASTTPSSSKH 1719

  Fly   188 KSWTLSPQSGGSTPLSGAKKKTKTGAPTTTLSNANGDGFNLWVARECFETVPAEMVDTLSMAEVD 252
            :|:::...|.....|:.:.|.|.:||...|.|:....|:|.
  Fly  1720 QSYSVKSFSHAMNALTASAKGTPSGALDATSSSTTAGGYNY------------------------ 1760

  Fly   253 EEVDEEEDEEAAAVESLLGAAAALQASAHVQRRQQQQHHQHLRQPSPPQHRPLERSWPPRAVGRD 317
                     .::|..|..||.||.    .|.::...:.:.|.:||:.|...|.:...|     ..
  Fly  1761 ---------SSSAPSSSSGAPAAY----FVTQQGDPRQYVHFQQPAVPAPPPQQELLP-----SG 1807

  Fly   318 LKLQGDVFQFDILDTDERLAEEMAQGSGSSNNSPLATPPVRFKPLLKKKIGPDSYINTISTQKVP 382
            ::.||.                             ..|.|.::|..::    .:::...||....
  Fly  1808 VQQQGQ-----------------------------QVPQVIYQPHHQQ----PAHLVLASTSSGA 1839

  Fly   383 VHQSYEFPTFPSSSAVGSSSSSPNSLQFPYL----RQHRPLTRALSNGKASSSEEQASPRLLLSP 443
            .          |||:..|||||.::||....    |:..|..::.|.|:|.|.:|
  Fly  1840 A----------SSSSSSSSSSSASALQHKMTDMLKRKAPPKRKSQSGGRAKSRQE---------- 1884

  Fly   444 KRPRSPPSGCSTRSASPLDISLSPEQHSPTRGRGVGGALQDAVPPGTPTFHGQRPQQRLLKR--- 505
                              |.:::|      .|.|.|||     ||.:    .......||.|
  Fly  1885 ------------------DAAVAP------AGSGPGGA-----PPSS----SGSAMHELLSRATS 1916

  Fly   506 VGGGAGAGAT---GGATGSPLVCPPTPTHHARRHARLQAVTANSSLASGGAIPSDPPAVSSQLDY 567
            :|.|.|..:|   ||.:||             ..:|..|  .|||.|..        :.||.|..
  Fly  1917 LGSGNGGRSTPNSGGGSGS-------------SKSRFNA--GNSSNAGS--------SKSSFLAS 1958

  Fly   568 IYLQDGGQEQGQ------EQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSG 626
            :.....|::..|      :||.:..|       .:.:.|..:.:..:.:.||.|......|..||
  Fly  1959 LNPARWGRQTHQNHHHHHQQSQQQHH-------GLSKDSGNSNSTGSGSGAGLAYTVSQHGAGSG 2016

  Fly   627 SSGAGAAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLD--RR 689
            :.|..||.    ..|..::..||..:....:..|...|.|                .|.:|  :|
  Fly  2017 AGGLNAAA----VAASISKSISHANLLAAANRERARQWVR----------------EQAVDFVKR 2061

  Fly   690 Y---QSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAIL--------------- 736
            |   ::.|....:||.|.|      |.:|....::....|.:||....:|
  Fly  2062 YTEQEAKRSKAASESGATQ------SGSSGVGLSSTGNTPLSTAGSTNVLERLSSILFKLNGSYH 2120

  Fly   737 -----------MLCRPDF--YSLLH-----------TNEAALAIYNRNAALK---HMVMRIRRDP 774
                       :|...|.  :.:.|           |:|..|.  .|:|.|:   |:...:..:|
  Fly  2121 DCLDALLELKTILLESDISPFEVNHSGLIKAMLNYMTSETGLV--ERDARLRSFMHVFAGLPLEP 2183

  Fly   775 --------PCFQRYQYNKDLVALVNTFAQMSR------ELPSCWETKLDQSGKQFFIDHQHRRTS 825
                    |..:...:...:..|.....|:.:      :.|:....:.:||..:||..||
  Fly  2184 LLQNVGQMPTIEPIAFGAFVAKLNGCVTQLEQFPVKVHDFPAGPGGRSNQSALRFFNTHQ----- 2243

  Fly   826 FMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPD-----------LV------------------- 860
                   ::| .:.||.|.::.:|...|....|           ||
  Fly  2244 -------LKC-NLQRHPQCNNLRQWKGGTVKIDPLAMVQAIERYLVVRGYGGIRADSDDDSEEDM 2300

  Fly   861 DGNC-------------LSATSG-HI---NASPASSVSGVPPLPPPRP----------------- 891
            |.|.             |..|.| |:   |.:...:|....||...:|
  Fly  2301 DDNVAAVVLSQASFRHKLQFTIGDHVLPYNMTVYQAVKQFSPLVSEQPETDNESETLLGNASIWV 2365

  Fly   892 ---------------------SSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGA 935
                                 ::|||||.||.......:::||.|| :||..|...::|:||.|.
  Fly  2366 QQHTIHYRPVEEEVTSGAAAGAASSSSSCSSGVQKQQSSSSSASSC-VNATSSCSSSSGVASGGG 2429

  Fly   936 TAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGV----------- 989
            :..                            ::...:.|:.:|:|..:.. ||:
  Fly  2430 SLT----------------------------KKAHKSSSKFMRKKTELWH-EGIAPVVISALKPF 2465

  Fly   990 -----PALERLGHDLQLTIL--------LSLFEQEIMGFVPIEERSPQGS--------------- 1026
                 ||......|..|..|        |:.....:.|.|..:...||..
  Fly  2466 LSSSLPADVVTVQDASLDALCMLRVIHALNRHWDHLYGCVVRQNIIPQSDFIHPKIMAKANRQLQ 2530

  Fly  1027 ---PVLNSRMPQRAPP-----PFRRDFEAKLRSFY-------RKLE--------------SKGYG 1062
               .::...:||..|.     ||...||.:...||       |.|:              |:...
  Fly  2531 DPLVIMTGNLPQWLPQIGMACPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDLNAAESSERVA 2595

  Fly  1063 QGPHKLKLHIRRSHLLEDAFRRIMS-ANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELF 1126
            ....:.|..|.|:.:|:.|...:.. .:.|.|    |.:.::.|.|... ||:.||:.|:|.||.
  Fly  2596 PRLDRRKRAISRTEILKQAEHILQDFGHSKAL----LEIQYENEVGTGL-GPTLEFYALVSAELQ 2655

  Fly  1127 NPYYGLF---------------------------------------------------------- 1133
            ....||:
  Fly  2656 RTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTT 2720

  Fly  1134 ---------------------------EYSA---------------------------------- 1137
                                       |:|:
  Fly  2721 AQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPSS 2785

  Fly  1138 --------------NDTYTVQVSPLSAFVDNCHDW--------------------FRFSGRVLGL 1168
                          |::..:..:..:::|...|..                    |:|.|:.:..
  Fly  2786 TTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKAKFKFLGKFMAK 2850

  Fly  1169 ALVHQYLLDAFFTRPFYKALL--RLPVALSDLESLDNEFHQSLQWIRDNDI-------------- 1217
            |::...:||..|:.|||:.|:  ...:.|:||..:..|...:|  :|..|:
  Fly  2851 AVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTL--VRLQDLVRQREYILSDPNID 2913

  Fly  1218 --------------GTGV-DLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWR 1267
                          |..: ||||.|     :|....:.||..||::..:...|..:|:..:..|.
  Fly  2914 AMEKTEKIEQLDLDGCPIADLGLDF-----VLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWF 2973

  Fly  1268 LERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGT-AEIDTNDWRLNTEYRS-----GYH 1326
            |..|||:|.|:|..||..|...:.:.:|...|||.|..|: :|...:.|.:.....|     |:|
  Fly  2974 LIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFH 3038

  Fly  1327 DNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPN-ALPR 1390
            .:.|.|.:.::::..::.:::...||||||:..:|..||.||.......|..:::...|| .||.
  Fly  3039 QDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPS 3103

  Fly  1391 AHTCFNRLDLPPYPTPELLYEKLLLAVEE 1419
            ..||.|.|.||.|.:.|::.:||.:|..|
  Fly  3104 VMTCVNYLKLPDYSSREVMRQKLKVAANE 3132

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	5/28 (18%)
		HECTc	1068..1424	CDD:238033	108/544 (20%)
		HECTc	1092..1423	CDD:214523	102/519 (20%)
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442	21/108 (19%)
		HECTc	<2818..3138	CDD:294058	84/322 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900