DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and CG5087

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster

Alignment Length:	989	Identity:	227/989 - (22%)
Similarity:	371/989 - (37%)	Gaps:	264/989 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   636 PPLPPAWEARMDSHGRIFYIDHT----TRTTSWQ--RPGAAPSGGPAGRE-----QHHRQQLD-- 687
            |.|.|  |...||.....:: ||    |...||.  |........||.::     |.|..|.|
  Fly   150 PELKP--ENHADSLSLALFL-HTLVVFTAPKSWAILRNAQFEKLQPAMQKICCNIQGHLVQHDFY 211

  Fly   688 --RRYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLC-RPDFYSLLHT 749
              .|...||.|:..|                      .:..|.|.:  ||:.|| ||    |:..
  Fly   212 KIMRLVLIRGTVREE----------------------LSVKPVTLV--AIITLCLRP----LIDG 248

  Fly   750 NEAALAIYNRN-------------AALKHMVMRIRRDPPCFQRYQ---YNKDLVAL---VNTFAQ 795
            |      ::||             |.:.|:...:   |.|.:::.   ..|..:::   |..|.:
  Fly   249 N------FSRNLLAKFLSEILSVPALIYHLQQSV---PQCLEQFSSMGLLKKALSISGDVQWFEE 304

  Fly   796 MSRELPSCWETK----LDQSGKQFFIDHQHRRTSFMDPRLPVE-------CPRVVRHRQQHSQQQ 849
            ....:|.   ||    |......|.||.|........|.|...       .|..|..:...:|..
  Fly   305 FGTSMPG---TKSLAFLGNIVNLFNIDGQGESKELAYPLLTETTTSLLELIPNTVTTKGVFTQWH 366

  Fly   850 SSVGYYYPD------------------LVDGNCLSATSGHINASPASSVSGVPPLPPPRPSSSS- 895
            ..:|::.|.                  |.|..|:....|.:......:...:....|.:||.|:
  Fly   367 ELLGWHTPGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNYERIEFQSPQQPSISNL 431

  Fly   896 ------------------SSSRSSHGHGHNCNTTSAIS----CALNADRSAYGAAGMASAG---- 934
                              :||:.|.......::...:.    |.:     .|.|....|..
  Fly   432 LRRALERSSTRGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICGM-----YYAALNTLSQMKLDI 491

  Fly   935 ATAAGYEDVPIAYNEKVIAFLRQPN-----ILEILRERQG------------------------Q 970
            .|...|.| .:.|:..::.....||     .||:|:....                        :
  Fly   492 LTGICYSD-NVLYDIWLLITSLGPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDE 555

  Fly   971 HTMSRQ-------------------LREKINILRVEGVPALERLGHDLQL---TILLSLFEQEI- 1012
            |.|..:                   |.:.||...:.|  |...:.|.:.|   |::|.|:.::.
  Fly   556 HEMYTEQNPFKLNDYVLLTYFLNNILYKLINDNLLAG--AKNIVQHPVFLSLHTLMLCLYRRDCR 618

  Fly  1013 MGFVPIE----------------ERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGY 1061
            ..|.|.:                |::.:.:.:|.::||...|      .|.:::.|.:.::::..
  Fly   619 RPFTPPKHWLIPEVKPSTFINDLEKAKRNAMLLLAKMPHIIP------HEDRVKLFRKFVQNEKA 677

  Fly  1062 GQG--------PHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGL-----DYGGP 1113
            ..|        |....:.|.|..::||.:|: ::|......:|.:.|.:..::||     |..|.
  Fly   678 VMGLTESACASPRSALIVIHRDRIVEDGYRQ-LAAQPTQALKGVIRVRFINQQGLHEAGIDQDGV 741

  Fly  1114 SREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDA 1178
            .:||.....:::|:|...||:.:::.  .:..||:|...||..:.|.|.||:||.|:....::|.
  Fly   742 FKEFLEETIKKVFDPSLNLFKTTSDQ--RLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDV 804

  Fly  1179 FFTRPFYKALL-----RLPVALSDLESLDNEFHQSLQWIR--DNDIGTGVDLGLTFCVTEELLGS 1236
            .|...|...||     .|...:.:|.|||||.::||.:|:  ..|:.   ||.|||.|.::::|.
  Fly   805 PFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVS---DLNLTFSVDQDVMGK 866

  Fly  1237 VVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELE 1301
            :|...|.||||..::|:.||..|:..|..:.:...::|||.:..|||..:::...:|:|...||:
  Fly   867 IVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQ 931

  Fly  1302 LVIAG-TAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIER-FSNEQRLRLLQFVTGTSSIPYEG 1364
            .:|:| |:.:|..|.:.:|.|..|:||.|||:.|.|.::.: |:.|:|...|:|||..|..|..|
  Fly   932 RLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLG 996

  Fly  1365 FSALR--------------------GSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELL 1409
            |:.|.                    ||.....|.|.|....|.||.:.||||.|.||.|.....|
  Fly   997 FAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTL 1061

  Fly  1410 YEKLLLAVEETNTF 1423
            .:||..||.....|
  Fly  1062 RDKLRYAVSSNTGF 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	10/34 (29%)
		HECTc	1068..1424	CDD:238033	123/390 (32%)
		HECTc	1092..1423	CDD:214523	116/364 (32%)
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	123/388 (32%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	116/361 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447002
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740