Protein Alignment CG42797 and Smurf

DIOPT Version :9

• Sequence 1: NP_572574.2
• Gene: CG42797 / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_001261061.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Alignment Length: 1200
• Identity: 324/1200 - (27%)
• Similarity: 469/1200 - (39%)
• Gaps: 411/1200 - (34%)

  Fly   287 QQQHHQH------LRQPSPPQ------------HRPLERSWPPRAVGRDLKLQGDVFQFDILDTD 333
            ||:|:.|      .:.|:.|.            ||           .|||         .:..:|
  Fly   213 QQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHR-----------SRDL---------SVTASD 257

  Fly   334 ERL-AEEMAQGSGSSNNSPLATPPVRFKPLLKKKIGPDSYINTIST-----QKVPVHQSYEFPTF 392
            ||. :.|:....|..|.||  |.||.......||   .|..|:.|.     ::.|.::    |..
  Fly   258 ERRHSTEILSSVGKENTSP--TTPVSATTTPGKK---TSSSNSSSAGGRTLEQRPTNE----PAT 313

  Fly   393 PSSSAVGSS---SSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSPPSGCS 454
            |:||...:|   .|:.|.::.|   :|:      :||.|                    ||....
  Fly   314 PTSSTTSASVRLHSNDNHVKTP---KHQ------TNGHA--------------------PPESTP 349

  Fly   455 TRSASPLDISLSPEQHSPTRGRGVGGALQ-----------DA---VPPGT---PTFHGQRPQQRL 502
            |......:......|:..|.|.|.|.|.|           ||   ..|.|   |..|.|.|.
  Fly   350 TSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTTSPSTTTSPPRHSQSPP--- 411

  Fly   503 LKRVGGGAGAGATGGATGSPLVCPP---TPTHHARRHARLQAVTANSSLA-SGGAIPSDPPAVSS 563
                              :|.:.||   ||:.:...|    :..|||:.| |||...|...|...
  Fly   412 ------------------TPNISPPASVTPSANGNVH----SPNANSTPAGSGGGSRSYTAATPG 454

  Fly   564 QLDYIYLQDGGQEQGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSGSS 628
            |...   :...::||:|        ||||     .||:........:..|..   .|:|....|:
  Fly   455 QRSQ---RRSSRQQGEE--------SSTR-----RRSSRGTRNGGTSGGGGG---GGSGQRYASA 500

  Fly   629 GAGAAGEP-----PLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDR 688
            ...||.:.     .|||.:|.|....|::::....|..::|..|
  Fly   501 AIAAANQAARPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDP--------------------- 544

  Fly   689 RYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAA 753
                                                                             
  Fly   545 ----------------------------------------------------------------- 544

  Fly   754 LAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFID 818
                           ||.||   |.......|.:.          .|||.||.:...||:.:|:|
  Fly   545 ---------------RIPRD---FDTQHLTLDAIG----------PLPSGWEQRKTASGRVYFVD 581

  Fly   819 HQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPA--SSVS 881
            |.:|.|.|.||||.....:::|.........::.|              |....:|:||  |:.:
  Fly   582 HNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAG--------------TPAPPSATPATPSAAA 632

  Fly   882 GVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIA 946
            .|||...|..:::.::..::....|
  Fly   633 AVPPQATPASNATPTTLTTTTNPPH---------------------------------------- 657

  Fly   947 YNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQE 1011
                                                           |:..||...:|
  Fly   658 -----------------------------------------------RIVPDLPQGLL------- 668

  Fly  1012 IMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSH 1076
                        :|:.:|         |.:|||...|||:...:|::. ..|..| .:|.:.|:.
  Fly   669 ------------EGADLL---------PKYRRDLVGKLRALRTELQTM-QPQSGH-CRLEVSRNE 710

  Fly  1077 LLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTY 1141
            :.|:::|.||....||: |.||.|.:..||||||||.:||:..|||||:.||.||||:||.:|.|
  Fly   711 IFEESYRLIMKMRAKDM-RKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHY 774

  Fly  1142 TVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFH 1206
            |:|::|.|....:...:|.|.||.||:|:.|.:.||..||.||||.||..|:.|.|:|.:|.:.|
  Fly   775 TLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLH 839

  Fly  1207 QSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERG 1271
            :||.|:.:::| :|: :..||.|.....|::|..||||||.:|.:.|:||:||::..:.:|..||
  Fly   840 RSLTWMLESNI-SGI-IESTFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRG 902

  Fly  1272 VQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFW 1336
            :::|..:|.:||.|:|.|.|:..||.|||||||.|.:.||.||||.||..:...::..||: |||
  Fly   903 IEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHCTNETTQVL-WFW 966

  Fly  1337 QVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGST---GPRRFCIEKWG--KPNALPRAHTCFN 1396
            ||:|.:|:|.|.||||||||:|.:|.:||.||:|||   |||.|.|....  ....||:||||||
  Fly   967 QVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFN 1031

  Fly  1397 RLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            |:|||||.|.:||.:||..|||||..|.:|
  Fly  1032 RIDLPPYETYQLLCDKLTQAVEETCGFAVE 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	8/28 (29%)
		HECTc	1068..1424	CDD:238033	173/360 (48%)
		HECTc	1092..1423	CDD:214523	166/335 (50%)
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736	9/132 (7%)
		WW	562..594	CDD:197736	15/31 (48%)
		HECTc	702..1058	CDD:238033	173/359 (48%)
		HECTc	726..1058	CDD:214523	166/335 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446960
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840