DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and Hectd1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_006240148.1	Gene:	Hectd1 / 362736	RGDID:	1561653	Length:	2610	Species:	Rattus norvegicus

Alignment Length:	1645	Identity:	308/1645 - (18%)
Similarity:	512/1645 - (31%)	Gaps:	578/1645 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 TLSPTNSYNGS--------IGSDGGSSVGGGARRKSWTL-----------SPQSGGSTPLSGAKK 207
            ||.....|..|        :..||          ::||.           .|.|..:.||..||.
  Rat  1151 TLRHARGYGRSALRNWVFQVSKDG----------QNWTSLYTHVDDCSLNEPGSTATWPLDPAKD 1205

  Fly   208 KTKTGAPTTTL----SNANG-------DGFNLWVARECFETVPAEMVDTLSMAEVDEEVDEEEDE 261
            : |.|.....|    .||:|       .||      |.:.||.....|.|
  Rat  1206 E-KQGWRHVRLKQMGKNASGQTHYLSLSGF------ELYGTVNGVCEDQL--------------- 1248

  Fly   262 EAAAVESLLGAAAALQASAHVQRRQQQQHHQHLRQPSPPQH--RPLERSW-----PPRAVGRDLK 319
                      ..||.:|.|:::|:::....|.|:...|...  |.|:..|     .|:..|   .
  Rat  1249 ----------GKAAKEAEANLRRQRRLVRSQVLKYMVPGARVIRGLDWKWRDQDGSPQGEG---T 1300

  Fly   320 LQGDVFQFDILDTDERLAEEMAQGSGSSNNSPLATPPVRFKPLLKKKIGPDSYINTISTQKVPVH 384
            :.|::....|         ::...:|.||:..:.... :|...|.....||    |:::.|
  Rat  1301 VTGELHNGWI---------DVTWDAGGSNSYRMGAEG-KFDLKLAPGYDPD----TVASPK---- 1347

  Fly   385 QSYEFPTFPSSSAVGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSP 449
                    |.||.|..::.|.:||    ::.:.|...:.:.|.:|               |..|.
  Rat  1348 --------PVSSTVSGTTQSWSSL----VKNNCPDKTSAAAGSSS---------------RKGSS 1385

  Fly   450 PSGCSTRSASPLDISLSPE----------QHSPTRGRGVGGAL-----QDAVP---------PGT 490
            .|.||..|:|  ||||...          :||...|..|...:     .:.||         ..|
  Rat  1386 SSVCSVASSS--DISLGSTKTERRSEIVMEHSIVSGADVHEPIVVLSSAENVPQTEVGSSSSAST 1448

  Fly   491 PTFHGQRPQQRLLKRVGGGAGAGATGGAT---------GSPLVCP-------------PTPTHHA 533
            .|...:...:...:::|..:...|.|.::         .||.|..             |..:..:
  Rat  1449 STLTAETGSENAERKLGPDSSVRAPGESSAISMGIVSVSSPDVSSVSELTNKEAASQRPLSSSAS 1513

  Fly   534 RRHARLQAVTANSSLASGGAIPSDPPAVSSQLDYIYLQ---------DGGQEQGQEQSDEVVH-- 587
            .|.:....:.|.:.::|..::|:.....:|.|:....:         .......:..||...:
  Rat  1514 NRLSVSSLLAAGAPMSSSASVPNLSSRETSSLESFVRRVANIARTNATNNMNLSRSSSDNNTNTL 1578

  Fly   588 ----ISSTRLP-----SIPE------------------RSAAAAAAAAAAAAGAALMEPGTGTVS 625
                :|:...|     |.|.                  .|:..|.|....:.|.:|....|.:::
  Rat  1579 GRNVMSTATSPLMGAQSFPNLTTPGTTSTVTMSTSSVTSSSNVATATTVLSVGQSLSNTLTTSLT 1643

  Fly   626 GSSGAGAAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRY 690
            .:|.....|:       ||....:..:.....:|...........|.......|.....|.|:.|
  Rat  1644 STSSESDTGQ-------EAEYSLYDFLDSCRASTLLAELDDDEDLPEPDEEDDENEDDNQEDQEY 1701

  Fly   691 QSI--------------RRTITNESRAAQLYNLPTSANSNA------------------------ 717
            :.:              |..:|:.:..:||..:|:.|.|..
  Rat  1702 EEVMILRRPSLQRRAGSRSDVTHHAVTSQLPQVPSGAGSRPIGEQEEEEYETKGGRRRTWDDDYV 1766

  Fly   718 -----NSTAPA-----------------APPPATAIHPAIL--MLCRPD--------FYSLLHTN 750
                 ::..||                 .|||.|. |..:|  :.|.|.        ...|..|.
  Rat  1767 LKRQFSALVPAFDPRPGRTNVQQTTDLEIPPPGTP-HSELLEEVECTPSPRLALTLKVTGLGTTR 1830

  Fly   751 EAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELP-----------SCW 804
            |..|.:.|..:.:.:.|.::.: ..|....:.:|.......|:..|.||:.           .||
  Rat  1831 EVELPLSNFRSTIFYYVQKLLQ-LSCNGNVKSDKLRRIWEPTYTIMYREMKDSDKEKENGKMGCW 1894

  Fly   805 ETK-------LDQSGKQFFIDHQHRR--TSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLV 860
            ..:       .|:..|...|.:..:.  .:|:.........:.:|..:..||..::    |.|.
  Rat  1895 SIEHVEQYLGTDELPKNDLITYLQKNADAAFLRHWKLTGTNKSIRKNRNCSQLIAA----YKDF- 1954

  Fly   861 DGNCLSATSGHINASPASSV--SGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRS 923
               |...|...:|...:||:  |.:..|...:|.:.:       |:|.|
  Rat  1955 ---CEHGTRSGLNQGASSSLQSSDILNLTKEQPQAKA-------GNGQN---------------- 1993

  Fly   924 AYGAAGMASAGATAAGYEDV----PIAYNEKVIAFLRQPNILEILRERQGQHTM------SRQLR 978
                         ..|.|||    .|.|   ::|......|.:...:.|.|.|.      |:::.
  Rat  1994 -------------PCGVEDVLQLLRILY---IVASDPYSRISQEDGDEQPQFTFPPDEFTSKKIT 2042

  Fly   979 EKINILRVEGVPALERLGHDLQLT--ILLSLFEQ---EIMGFVPIEER----------SPQGSPV 1028
            .||          |:::...|.|.  .|....||   :....:|.|.|          :.:....
  Rat  2043 TKI----------LQQIEEPLALASGALPDWCEQLTSKCPFLIPFETRQLYFTCTAFGASRAIVW 2097

  Fly  1029 LNSRMP-----QRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMS- 1087
            |.:|..     .|.....|||...:.|          .|:..|: ::.:.|...|.:....:|.
  Rat  2098 LQNRREATVERTRTTSSVRRDDPGEFR----------VGRLKHE-RVKVPRGESLMEWAENVMQI 2151

  Fly  1088 -ANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSREL-------------------------- 1125
             |::|.:    |.|.:..|||... ||:.||:.|::.|.
  Rat  2152 HADRKSV----LEVEFLGEEGTGL-GPTLEFYALVAAEFQRTDLGTWLCDDNFPDDESRHVDLGG 2211

  Fly  1126 -FNP--YY-----GLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTR 1182
             ..|  ||     |||        |......|..::.....|.|.|..|...:....|:|...::
  Rat  2212 GLKPPGYYVQRSCGLF--------TAPFPQDSDELERITKLFHFLGIFLAKCIQDNRLVDLPISK 2268

  Fly  1183 PFYKALLR-------------------LPVALSDLESLDNEFHQSLQ------------------ 1210
            ||:|.:..                   |....|..|:...|.|.||.
  Rat  2269 PFFKLMCMGDIKSNMSKLIYESRGDRDLHCTESQSEASTEEGHDSLSVGSFEEDSKSEFILDPPK 2333

  Fly  1211 ------------W----------------IRD-----------------------------NDIG 1218
                        |                |:|                             |..|
  Rat  2334 PKPPAWFNGILTWEDFELVNPHRARFLKEIKDLAIKRRQILGNKSLSEDEKNTKLQELVLKNPSG 2398

  Fly  1219 TG-----VDLGLT--FCVTEELLG-SVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQ 1275
            :|     .||||.  ||.:..:.| :.||  |||.|::.:|...|.:||::.|..:.:..|:|:|
  Rat  2399 SGPPLSIEDLGLNFQFCPSSRIYGFTAVD--LKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQ 2461

  Fly  1276 TESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLN-----TEYRSGYHDNHQVIVWF 1335
            .|:...||.:|.....:|.|...|:::::.|.   .:..|...     ||.:.||..:....:.|
  Rat  2462 MEAFRDGFNKVFPMEKLSSFSHEEVQMILCGN---QSPSWAAEDIINYTEPKLGYTRDSPGFLRF 2523

  Fly  1336 WQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNA-LPRAHTCFNRLD 1399
            .:|:...|:::|...|||.||.|::|..|.:.|.    ||...:.|....:| .|..:||.:.|.
  Rat  2524 VRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLH----PRLTVVRKVDATDASYPSVNTCVHYLK 2584

  Fly  1400 LPPYPTPELLYEKLLLAVEE 1419
            ||.|.:.|::.|:||.|..|
  Rat  2585 LPEYSSEEIMRERLLAATME 2604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	3/28 (11%)
		HECTc	1068..1424	CDD:238033	110/496 (22%)
		HECTc	1092..1423	CDD:214523	105/470 (22%)
Hectd1	XP_006240148.1	Ank_2	366..457	CDD:289560
		ANK repeat	366..393	CDD:293786
		ANK	369..479	CDD:238125
		ANK repeat	396..426	CDD:293786
		ANK repeat	428..457	CDD:293786
		F5_F8_type_C	1107..1240	CDD:304887	23/105 (22%)
		MIB_HERC2	1277..1335	CDD:284184	11/70 (16%)
		HECTc	2131..2608	CDD:238033	110/497 (22%)
		HECTc	2155..2607	CDD:214523	106/472 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900