DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and Ufd4

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster

Alignment Length:	1666	Identity:	312/1666 - (18%)
Similarity:	518/1666 - (31%)	Gaps:	576/1666 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LTNDVHVSVSEVEEHEPPLASRNQEVAEVEEQQQQL--GA---------------CALPQPSEAS 132
            :.:|:..||.|.|      |...:|..::..|.:.:  ||               ||     |.:
  Fly  1301 VADDIGKSVKEAE------AKTRRERRQIRAQLKHMTTGARVIRGVDWRWEEQDGCA-----EGT 1354

  Fly   133 LTGSKETREPRHHQTLLSTKSCETPANNATLSPTNSYNGSIGS-------DGGSSVGGGARRKSW 190
            :||       ..|...:..|......|:..:.....|:..:..       ||..|:|..    |.
  Fly  1355 ITG-------EIHNGWIDVKWDHGVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSA----ST 1408

  Fly   191 TLSPQSGGSTPLSGAKKKTKTGAPTTTLSNANGDGFNLWVARECFETVPAEMVDTLSMAEVDEEV 255
            ...|...|...|:..|..:....|..|..|.|.:|.:       .:||.|   |.|:..:..|.:
  Fly  1409 AAKPSEKGGNTLTSRKSSSTPSLPEATEKNQNPEGAS-------NQTVSA---DNLAWKQTVETI 1463

  Fly   256 DEEEDEEAAAVESLLGAAAALQASA-------HVQRRQQQQHHQHLRQPSPPQHRPLERSWPPRA 313
              .|:..|:|...::....|:..|:       |.:....|.|..::..|||
  Fly  1464 --AENVFASAKTQIISNQLAMNTSSSREARAKHKESGTNQMHKDNISGPSP-------------- 1512

  Fly   314 VGRDLKLQGDVFQFDILDTDERLAEEMAQGSGSSNNSPLATPPVRFKPLLKKKIGPDSYINTIST 378
            :.|:|:...|:...:          .......|||.|.|||            |..:..:..:|.
  Fly  1513 LSRELEHISDLSAIN----------NSMPAINSSNVSDLAT------------ISENLSLTELSK 1555

  Fly   379 QKV--PVHQSYEFPTFPSSSAVGSSSSSPNSLQFPYLRQH--RPLTRALSNGK--ASSSEEQASP 437
            :.:  .:..||:    |:.|...|.|||...:|....|::  :.::....|.|  |::|..:.|.
  Fly  1556 ENICRVLTPSYK----PAESVTASQSSSHPDVQSSSPRENDIKNISNIEENNKMNANNSVNKISK 1616

  Fly   438 RLLLSPKRPRSPPSGC------STRSASPLDISLSPEQHSPTRGRGVGGALQDAVPP-------- 488
            .||.:.:  .|..:||      ||.:...:|                  .::|.|..
  Fly  1617 DLLANLR--TSNIAGCPPVTQLSTEALEMID------------------KMRDGVDMIRNMSNSI 1661

  Fly   489 -GTPTFHGQRPQQRLLKRVGGGAGAGATGGATGSPLVCPPTPTHHARRHARLQA----------- 541
             .|.||                            |:.|...|. ..::..:.||
  Fly  1662 LSTDTF----------------------------PVPCTNVPV-GGKKTPKAQALINPDNANQKQ 1697

  Fly   542 --VTANSSLASGGAIPS-------DPPAVSSQLDYIYLQDGGQEQGQEQSDEVVHI---SSTRLP 594
              ||:..........||       .|.||.|.:|.         :.|..|:|.|.:   .|..:|
  Fly  1698 IIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVDI---------KEQPISNENVSVPSQMSISVP 1753

  Fly   595 SIPERSAAAAAAAAAAAAGAALMEPGTGTVSGSSGAGAAGEPPLPPAWEARMDSHGRIFYIDHTT 659
            ::...||:...:.:..|....|:|.........:..|...:.......||.::.||     |...
  Fly  1754 NLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDNQIMNAEANVNEHG-----DQNA 1813

  Fly   660 RTTSWQRPGAAPSGGPAGREQHHRQQLDRRYQSIRRTITNESRA-----AQLYNLPTSANSNANS 719
                        ||...|   |....|      ::..:::...:     ||.|  |:.:::|:.:
  Fly  1814 ------------SGSFLG---HSVTSL------VKLALSSNFHSGLLSTAQSY--PSLSSNNSEN 1855

  Fly   720 TAPAAP-------PPATAIHPAILM-------------------LCR------------------ 740
            .||:.|       ..|:.|:..:.|                   .||
  Fly  1856 IAPSNPSNTSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDN 1920

  Fly   741 -----PDFYSLLHTNEAALAIYNRN-------AALKHMVMRIRRDPPCFQRYQYNKDLVALVNTF 793
                 .|.|..: .|.....:.:||       .|:::.::.:.:.......:...:...||:..|
  Fly  1921 DEEENEDEYEEV-GNTLLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAF 1984

  Fly   794 -----------------AQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRL----PVECP- 836
                             :.:..|||     |..|||....|:..........|.:    .||..
  Fly  1985 DPRPGRTNVNQTSDLEISPLGAELP-----KPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDL 2044

  Fly   837 --------RVVRHRQQHSQQQS------------SVGY--YYPDLVDGNCLSATSGHINASP-AS 878
                    |.|:...|.||...            ::.|  ..|:..:..||.  |.....:| .|
  Fly  2045 SNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCLE--SEEFPQTPDVS 2107

  Fly   879 SVSGVPPLPPPRPSSSSSSSRSSHGH-GHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYED 942
            |.||...|.|..|.           | |.|....:.  |:::
  Fly  2108 SKSGASTLSPNSPM-----------HIGFNVADNNL--CSVD----------------------- 2136

  Fly   943 VPIAYNEKVIAFLRQPNILEILRERQG--QHTMSRQLREKINILRVEGVPALERLGHDLQLT-IL 1004
                            ::||:|.:..|  |..:...::|       .||..   |..||.:: .:
  Fly  2137 ----------------DVLELLTQINGLNQSEIDSDVKE-------HGVSV---LSEDLFISKKI 2175

  Fly  1005 LSLFEQEIMG-FVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKL 1068
            .:..:|:|.. .|......|.....||...      ||...||.  |..|....|  :|.....:
  Fly  2176 TNKLQQQIQDPLVLASNALPNWCENLNQSC------PFLFPFET--RQLYFNCTS--FGASRSIV 2230

  Fly  1069 KLHIRRSHLLEDAFRRIMSANKKD--LQRGRL------------AVLWD---------------- 1103
            .|..:|...:|.....|||..:.|  .:.|||            .::|.
  Fly  2231 CLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLKHERVKVPRNEDLLMWAMQVMKTHCNRKSVLEV 2295

  Fly  1104 ---TEEGLDYGGPSREFFFLLSRELFNPYY-------GLFEYSANDTYTVQ-------------- 1144
               .|||... ||:.||:.|::.|:.....       .|.|.:.|.|.:.:
  Fly  2296 EFLDEEGTGL-GPTLEFYALVAAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRRE 2359

  Fly  1145 ----VSPL---SAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPV--------- 1193
                .:||   |...:|...:|.|.|..:...|....|:|...:..|.:.|....|
  Fly  2360 HGIFPAPLPQNSEICENVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVI 2424

  Fly  1194 ---------------------------------------ALSDLESLDNEFHQSLQWIRD----- 1214
                                                   :|.:|:.:|...:|.||.:::
  Fly  2425 SDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRK 2489

  Fly  1215 ------------------NDI------GTGV---DLGLTFC-VTEELLGSVVDRELKPGGKNIII 1251
                              |::      |..|   ||.|||. :....:......||.|.|.::.:
  Fly  2490 QSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVNV 2554

  Fly  1252 NEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGT--AEIDTND 1314
            ...|.:.|.|.::.:.|:.|:.:|.::...||.||...:.::.|...|..::|.|.  ......|
  Fly  2555 TIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQFPHWSRED 2619

  Fly  1315 WRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCI 1379
            ....||.:.||:.:......|..|:...|.::|...|||.||.||:|..|.:.|.    ||...:
  Fly  2620 IISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLH----PRLTVV 2680

  Fly  1380 EKW-GKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEE 1419
            .|. ....:.|..:||.:.|.||.|||.|::.|:||.|.:|
  Fly  2681 RKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTATKE 2721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	5/28 (18%)
		HECTc	1068..1424	CDD:238033	106/497 (21%)
		HECTc	1092..1423	CDD:214523	100/473 (21%)
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955	11/67 (16%)
		DamX	1576..>1725	CDD:330571	33/197 (17%)
		HECTc	2265..2725	CDD:238033	96/462 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447000
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830