DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and CG4238

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster

Alignment Length:	974	Identity:	225/974 - (23%)
Similarity:	369/974 - (37%)	Gaps:	238/974 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   622 GTVSGSSGAGAAGE----PPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHH 682
            |...|.|...:.|:    |.|||..|.|:..  ...::........|.:.         .|.|||
  Fly    71 GESMGISSLSSCGDPERLPELPPLDEQRLQR--AALHLQQKLILREWLKD---------HRLQHH 124

  Fly   683 RQQLDRRYQSIRRTI--TNESRAAQL------------YNLPTSANSNANSTAPAAPPPATAIHP 733
            .|:|.....:....:  ..:|||:::            .||||   |.|...|..|...:|.:..
  Fly   125 YQRLLAVEVASLEDVYWLEDSRASKILGKDWQLWSGARQNLPT---SKAQLDALKAQLWSTVVKS 186

  Fly   734 A------------ILMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKD- 785
            :            ::.:......:|....:.:||...|::.|:::..:......|..::.: ||
  Fly   187 SQHQDAWTWGGMLVVSVSVAGLVTLAAMTQPSLAPEARHSLLQYVTGKYLLPANCKVQWDW-KDP 250

  Fly   786 ------LVALVNTFAQMSRELPSCWETKLDQSGKQFFID--HQHRRT-------SFMDPRLP--V 833
                  :..:|..|.:..:..|.|       ....||::  ...|:.       |..||...  .
  Fly   251 ASVGGTMCFVVRFFQRNGQPYPIC-------DTDHFFVEVTEGTRKVVTISELGSSTDPNNANIA 308

  Fly   834 ECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATS--------GHINA------SPASSV---S 881
            :....||          :.|.|...::.|....|.|        |.|:|      .|||:|   :
  Fly   309 KVKFTVR----------TAGQYKISVLIGASHIAGSPFLRSFLPGAIDARRSRFIRPASTVICCA 363

  Fly   882 GVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYE--DVP 944
            |.|.|....|       |...|:          ||..:.::|     ..|..|...|.|:  .||
  Fly   364 GAPTLMHIEP-------RDEFGN----------SCLFDQNQS-----DEALQGYQVAIYDLHGVP 406

  Fly   945 I---------AYNE-----KVIAFLRQPNILEIL---RERQ-------------------GQHTM 973
            :         ||::     .|.|...:|..|..:   |::|                   .::..
  Fly   407 VEKLQHAIVFAYDKVNSRVSVTALFPEPTCLRAVISYRDQQLPNGDFDIIVLSSSDTTLVHKNIA 471

  Fly   974 SRQ--LREKINILRVEGV------PALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSP--- 1027
            ||:  :..:..:|.:.||      ..|..:|......|.....::.|:.|:|....:.:..|
  Fly   472 SRKHNICYEAKLLSIFGVSKNKPRKVLCYVGPKQNSLIFQVTIKEMILKFIPKRIATFRLCPSTK 536

  Fly  1028 --VLNSRMPQRAPPPFRRD----------------------------------FEAKLRSFY--- 1053
              .|...:.|...|.|..|                                  |:.|...||
  Fly   537 FHFLPQLVSQLHGPVFIIDDGAQPKIELASKDRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEV 601

  Fly  1054 RKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFF 1118
            ||..:..|.:   |:.|.::|..:||.:.:.:...:..| ..|...|.:..|:|:|:||..||:|
  Fly   602 RKFHASYYHE---KMALKVQREKILESSMKAVKGFSVSD-WCGNFEVTFQGEQGIDWGGLRREWF 662

  Fly  1119 FLLSRELFNPYYGLFEYSANDTYTVQVSP---LSAFVDNCHDWFRFSGRVLGLAL-------VHQ 1173
            .|:...||:...||| .:.:|.:...|.|   ..|.:...|  |.|:|:::|..|       .::
  Fly   663 ELVCSALFDARGGLF-CTFHDKHQALVHPNPTRPAHLKLKH--FEFAGKMVGKCLFESALGGTYR 724

  Fly  1174 YLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQS-LQWIRDNDIGTGVDLGLTFCVTEELLGSV 1237
            .|:.|.|:|.|...|:.|.|.....|..|.:.:.| :::|.|.|:.....|.|.|  .||:..|.
  Fly   725 QLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYF--VEEMYDSS 787

  Fly  1238 VDR-----ELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDA 1297
            ..:     ||.|.|....:....|.:||:.:.:.||...|:::.:|.::|...:|...|:|:||.
  Fly   788 SGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDE 852

  Fly  1298 RELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPY 1362
            .||||::.||.|...:|::.:........:..:|:.|||..:..||..:..|||||.||.|.:|.
  Fly   853 NELELLMCGTGEYSISDFKAHHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPP 917

  Fly  1363 EGFSALRGSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEE-TNTFGI 1425
            .||..|.     .:|.|........||.||||||:|.||.|.:.|...:.||||:.| :..||:
  Fly   918 GGFQELN-----PQFQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFGM 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	6/28 (21%)
		HECTc	1068..1424	CDD:238033	114/372 (31%)
		HECTc	1092..1423	CDD:214523	110/347 (32%)
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	20/115 (17%)
		Filamin	238..336	CDD:279024	20/115 (17%)
		HECTc	615..975	CDD:238033	114/370 (31%)
		HECTc	642..974	CDD:214523	108/341 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446950
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840