Protein Alignment Hecw and HERC2

DIOPT Version :10

• Sequence 1: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_608388.2
• Gene: HERC2 / 33035
• FlyBaseID: FBgn0031107
• Length: 4912
• Species: Drosophila melanogaster
• Alignment Length: 1674
• Identity: 335/1674 - (20%)
• Similarity: 538/1674 - (32%)
• Gaps: 523/1674 - (31%)

  Fly     4 PAAPVPLQPLAASSACLADRSPVDPIAVRLQQEEQAEGDDEEEEEEEEDDDDDPKEEEAFYEARN 68
            |....||| ||.:.|.....:|.|.....||:.                      ..||..:|..
  Fly  3463 PIMGAPLQ-LAETIAQGGGEAPADATDAGLQEH----------------------SPEAAVDALT 3504

  Fly    69 GNESDELE----------QAFQS---ALTLTNDVHVSVSEVEEHEPPLASRNQEVAEVEEQQQQ- 119
            |..|....          .||||   :|:::..:..|.....:|....||....:|....||::
  Fly  3505 GGMSGGANTLPPLSAGPLSAFQSLTGSLSMSGSLSSSALPQHKHSRMSASAMSVMAATMTQQEEM 3569

  Fly   120 ---LGAC--------ALPQPSEASLTGSKETR------EPRHHQTLLST---KSCETPANNATLS 164
               :..|        .|.:|...||....:..      .|...||:..|   ....|||..|.|.
  Fly  3570 LSHISHCHGLDDFGGLLGEPEAKSLVELLKLAVCGRCGPPSTSQTIADTLISLGAGTPAVAAMLL 3634

  Fly   165 PT---------------------------NSYNGSIGSDGGSSVGGGARRKSWTLSPQSGGST-- 200
            .|                           :.|..::...|...:.|....:   |...|..||
  Fly  3635 ETCITELEDLCTSRHCLGKLPKPVMQESSHPYVDNVNVTGVVRIPGAEMLR---LEFDSQCSTEK 3696

  Fly   201 ---PL-----SGAKKKTKTG------APTTTL------------SNANGDGFNLWVARECFETVP 239
               ||     :|.....::|      ||...:            |:.||.|:..||    ...:|
  Fly  3697 RNDPLVIMDGTGRVLAMRSGREFAHWAPEIRVLGDELRWKFSSDSSVNGWGWRFWV----HAIMP 3757

  Fly   240 AEMVD--------------TLSMAEVDEEVDEEEDEEAAAVESLLGAAAALQASAHVQR------ 284
            |..:.              .|.|:.:|..:...:......:.|.|.|.:.|.|....||
  Fly  3758 AATLGESGSDRAVLSQPSMALVMSLLDSRLAPRQPSVLLRLASALAACSQLGALTTAQRIWSLRK 3822

  Fly   285 -----------RQQQQHHQHLRQPSPPQHRPLERSW---PPRAVGRDLKLQGDVFQ-FDILDTDE 334
                       |.|......|.||..|:   |.|.:   .|:..|....:..|.|: ...|..|.
  Fly  3823 LHAVLLLEQAPRPQDPSLSTLLQPLIPE---LLRQYEYEEPQVRGGIHLMHSDYFKTLAALACDM 3884

  Fly   335 RLAEEMAQGSGSSNNSPLATPPVRFKPLLKKKIGPDSYINTISTQKVPVHQSYEFPTFPSSSAVG 399
            :|...:...|.||::|  |.|                  ..||:.. .||:...|..:..:..|.
  Fly  3885 QLDAALPATSSSSSSS--AAP------------------GAISSTG-DVHKWAWFKRYCIAVRVA 3928

  Fly   400 SSSSSPNSLQFPY-LRQHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSPPSGCSTRSASPLD- 462
            .|......|...: |...:.....|   .:|||...|:|              ||.:..||.|:
  Fly  3929 QSLIRRTELPRAFCLEVRKKFAEML---PSSSSNSNANP--------------GCQSPGASMLNS 3976

  Fly   463 -ISLSPEQHSPTRGRGVGGALQDAVPPG----TPTFH---------------------------- 494
             .|||....|..           :.|||    .|..|
  Fly  3977 TTSLSSSTVSNV-----------SPPPGITGEQPDLHCHAHQLESTSTLLHEDHTLFQAPHDAQL 4030

  Fly   495 ----GQRPQQRLLKRVGGGAGA---------GATGGATGSPLVCPP--------TPTHHARRHAR 538
                .:||....|.  .|||..         |..||..||.:..|.        .|...|.....
  Fly  4031 LQWLNRRPDDWALS--WGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQS 4093

  Fly   539 LQAVTANSSL-----ASGGAI---PSDP---PAVSSQLDYIYL---------------------- 570
            |.|||.:..|     .|||.:   .||.   |.:...|.::::
  Fly  4094 LFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVY 4158

  Fly   571 -----QDG----GQEQGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSG 626
                 :||    |.....::...|.|::...:..|    |..:|.:||..|...::..|.|.. |
  Fly  4159 AWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADI----ACGSAHSAAITASGHVLTWGKGRY-G 4218

  Fly   627 SSGAGAAGEPPLPPAWEARM----------DSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQH 681
            ..|.|.:.:...|...||.:          ....:...|.......||    .....|..||...
  Fly  4219 RLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSW----GDGDYGKLGRGGS 4279

  Fly   682 HRQQLDRRYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSL 746
            ...:|..:.:|:......:......:::..:.:.                  |:....:.||:.|
  Fly  4280 DGCKLPYKIESLAGLGVVKVECGSQFSVALTKSG------------------AVYTWGKGDFHRL 4326

  Fly   747 LHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVAL----VNTFAQMSRELPSCWETK 807
            .|.:                |..:||.          |.:.||    :.:.|..|....:|
  Fly  4327 GHGS----------------VDHVRRP----------KKVAALQGKKIISIATGSLHCVAC---- 4361

  Fly   808 LDQSGKQF-FIDHQHRR------TSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCL 865
             ..||:.: :.|:...:      |:...|||      |...:.:|             :|...|.
  Fly  4362 -SDSGEVYTWGDNDEGQLGDGTVTAIQRPRL------VAALQGKH-------------IVKVTCG 4406

  Fly   866 SATSGHINASPASSVS-GVPPLP-PPRPSS--SSSSSRSSHGHGHNCNTTSAISCALNADRSAYG 926
            ||   |..|...|.:| .:.||| ||....  ...:..:.|......:..|.:.|...|   ...
  Fly  4407 SA---HTLALSTSQLSERLRPLPNPPLEYDLVRDLAPEALHARLILLHHFSELVCPCLA---MLP 4465

  Fly   927 AAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQH----TMSR-QLREKINILRV 986
            .:|..|.||    .:|| :.||.|..||.:   :::....|..||    .::| |::...|  |.
  Fly  4466 ISGDLSLGA----LKDV-LVYNIKEAAFRK---VIQTTMVRDKQHGPVIELNRIQVKRSRN--RC 4520

  Fly   987 EGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSR---MPQRAPPPFRRDFEAK 1048
            .|:..::.         :.|:|.|.:           |..|:|...   :|.|.         .|
  Fly  4521 NGLAGIDG---------MKSVFGQMV-----------QKLPLLTQEALALPHRV---------WK 4556

  Fly  1049 LRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGP 1113
            ::.....::..|.|                   :...::....:||.|.:.:|.:|..|....|.
  Fly  4557 VKFVGESVDDCGGG-------------------YSESIAEMCDELQNGSVPLLINTPNGRGEAGA 4602

  Fly  1114 SREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDA 1178
            :|:.|      |.:|                  .||:.:.  .:.|||.|.::|:|:.....|..
  Fly  4603 NRDCF------LLDP------------------TLSSVLQ--MNMFRFLGVLMGIAVRTGSPLSI 4641

  Fly  1179 FFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIR--DNDIGTGVDLGLTFCVTEELLGSVVDRE 1241
            ....|.::.|....:..:||..:|.::...|..||  |:|......|.|.|..:     |....|
  Fly  4642 NLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNMDDDPKLFTALELPFSTS-----SARGHE 4701

  Fly  1242 LKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAG 1306
            :....:...|:.:|:.||:...:.:||.. ..||.:::..|..:||...|:|:|.|.||:.::.|
  Fly  4702 VPLSTRYTHISPRNRAEYVRLALGFRLHE-FDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCG 4765

  Fly  1307 TAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGS 1371
            :.:|.....:....|: |:..:..::.|||:|:|.|:|::|...|:||.|.:.:| ...:..||
  Fly  4766 SPDIPLGLLKSVATYK-GFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLP-RTIADFRG- 4827

  Fly  1372 TGPRRF---CIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAV 1417
               |.|   .:||....:.||.::|||..|.:|.|....:|.|||..|:
  Fly  4828 ---RDFVLQVLEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021	46/217 (21%)
		WW	638..667	CDD:459800	6/38 (16%)
		HECW1_helix	738..794	CDD:465766	10/59 (17%)
		HECTc	1068..1424	CDD:238033	88/355 (25%)
HERC2	NP_608388.2	ATS1	625..>894	CDD:444065
		Cyt-b5	1292..1364	CDD:459698
		MIB_HERC2	1928..1988	CDD:461991
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:463286
		APC10-HERC2	2762..2932	CDD:176485
		ATS1	2987..3320	CDD:444065
		RCC1	3302..3350	CDD:395335
		ATS1	4050..4389	CDD:444065	65/396 (16%)
		HECTc	4509..4880	CDD:238033	104/453 (23%)