Protein Alignment Hecw and Ube3a

DIOPT Version :10

• Sequence 1: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_061511705.1
• Gene: Ube3a / 3291570
• VectorBaseID: AGAMI1_003809
• Length: 1059
• Species: Anopheles gambiae
• Alignment Length: 1189
• Identity: 276/1189 - (23%)
• Similarity: 434/1189 - (36%)
• Gaps: 303/1189 - (25%)

  Fly   396 SAVGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSPPSGCSTRSASP 460
            |.:...|||..|..|. ....:...:..:||...||...:|.||           .|.:.||||
Mosquito    14 SRIDEESSSSGSRSFE-KDDSKQSNKQPNNGTLPSSSASSSGRL-----------RGTAGRSAS- 65

  Fly   461 LDISLSPEQHSPTR--------------GRGVGG--------ALQDAVPPGTPTFHGQRPQQRLL 503
               :|:.|:....|              .:|.|.        |....|...||.....|..|...
Mosquito    66 ---ALTSEEQELKRVSTKKLIERYFYQLMQGCGNPKCCNKNCASSGKVERLTPNAAAARAIQLFS 127

  Fly   504 KRVGGGAGAGATGGATGSPLVCPPTPTHHARRHARLQAVTANSSLASGGAIPSDPPAVSS----- 563
            :.        |...:...|.....|..||....:.....|.:.|:|.|...||...|..|
Mosquito   128 QE--------AALCSETQPSKLAKTDEHHHATGSSGSTSTCSPSVAQGSNEPSSADADRSNARWR 184

  Fly   564 ----------QLDYIYLQDGGQEQGQEQSDEVVHIS-STRLPSIPERSAAAAAAAAAAAAGAALM 617
                      ::|..|..........|:.|.....: ||..|..|..|::::::..:.......:
Mosquito   185 ECSKENKEVEKMDVAYDNSALDLDSMEEDDSSTKTTGSTAEPRKPSSSSSSSSSNTSHNTAQNHL 249

  Fly   618 EP----GT--------GTVSGSSGAGAAGEPPLPPAWEARMDSHGRIFYIDHT---TRTTSWQRP 667
            ||    ||        ..|..|||:||          :.:..:...:.|:|..   ..|....|.
Mosquito   250 EPLAAVGTLPAANSRNNNVGSSSGSGA----------KTKTQATEEVQYLDEAMLKELTERCIRE 304

  Fly   668 GA-APSGGPAGREQHHRQQLDRRYQ------SIRRTIT-------NESRAAQLYNLPTSANSNAN 718
            |: ||.....|......:.|...:|      ||.:.:.       ...:...|.:|....:.:.:
Mosquito   305 GSDAPLIRTLGAVFSSYRGLAASFQFCPAASSIEKMLARAPAGDLRNMKKEDLRSLEGDLDKDED 369

  Fly   719 STAPA-----APPPATAIHPAILMLCRPDFYSLLHTNEAAL----AIYNR-NAALKHMVMRIRRD 773
            |.||.     .|.||   |..:      |..||..:.:|..    |::.. |.||:.:...:.||
Mosquito   370 SKAPVESVPDVPDPA---HTTV------DVESLRSSMKALYAARPAVFGPINNALELLGKSLSRD 425

  Fly   774 PPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPV--ECP 836
              .......|.:|.:||..|.       ..:||.|  .|....::....|......||||  :|
Mosquito   426 --LRVGLTSNDELESLVTVFV-------IAFETLL--VGSADCLEGSFPRICAAVTRLPVWAQC- 478

  Fly   837 RVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSS 901
            |:||...:|.  :.|:......|.....:|..|.|       |..|:                ..
Mosquito   479 RLVRIWAEHC--KDSIHPLLQQLQQLITVSTLSMH-------SFRGI----------------RI 518

  Fly   902 HGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRE 966
            |.:...||.|.|:.....|:              ..|| |..|..|.|..:.....|:.|.::.|
Mosquito   519 HDNKVVCNATKAMKLVYYAN--------------ILAG-ELEPKHYRELDLRDTSLPSYLSLIPE 568

  Fly   967 RQGQHTMSRQLREK-------------INIL--RVEGVP-------------------------- 990
            .........::|.:             :|.|  |...||
Mosquito   569 DDDVRPADAEVRSRQKKVEDPFITELDVNPLDCRKPLVPYEEFYNELLCDVVEMDHDYLEYKSIA 633

  Fly   991 -----ALERLGHD-------LQLTILLS---------------LFEQEIMGFVPIEERSPQGSPV 1028
                 ||..:|.|       :|...:|:               ::.:..:.|:..:::..|.|..
Mosquito   634 SAVNGALSLIGTDPSTIFSFMQYAFILTPTTKTLALYYDSRIRMYSERRLSFLQQQQQLRQNSSA 698

  Fly  1029 LNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDA---FRRIMSANK 1090
            |.:..|.                                |.|.|||.|:::||   ...|..:|.
Mosquito   699 LQAVNPY--------------------------------LNLKIRRDHIIDDALVELEIIAMSNP 731

  Fly  1091 KDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNC 1155
            |||:: :|.|.:..|:|:|.||.|:|||.|:..|:|||.||:| .:..|:.||..:.:| |.:..
Mosquito   732 KDLKK-QLVVEFTGEQGIDEGGVSKEFFQLIIEEIFNPDYGMF-VTNEDSNTVWFNSIS-FENEA 793

  Fly  1156 HDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTG 1220
            .  |...|.|||||:.:..:|...|....|:.|:.:..:..||:.|:.....||:.:.|.   |.
Mosquito   794 Q--FTLIGIVLGLAIYNNIILAVNFPMVVYRKLMGMKGSFLDLKDLNPVLFNSLKSLLDY---TE 853

  Fly  1221 VDLGLTFCVT-----EELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLV 1280
            .|:...|..|     .::.|::::.||||.|..|.:.:.||::::|....:.|.:.|::|..:..
Mosquito   854 NDMEEVFMQTFKIGYRDVFGNLLEHELKPDGDKIFVTQDNKQDFVELYSDFMLNKSVEKQFNAFR 918

  Fly  1281 RGFYEVID-SRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSN 1344
            |||..|.| |.|..:|...|:||::.|:.|.|.::...:|||..|:....|.|..||.::...|.
Mosquito   919 RGFQMVTDESPLHLLFRPEEVELIVCGSKEFDFDELEQSTEYEGGFTAESQTIKDFWSIVHGLSM 983

  Fly  1345 EQRLRLLQFVTGTSSIPYEGFSALR---GSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTP 1406
            |.:.:||||.||:..:|..|.|.|:   ...||         ..:.||.:|||||.|.||.|.:.
Mosquito   984 EVKRKLLQFTTGSDRVPVGGLSRLKLVVARNGP---------DSDRLPTSHTCFNVLLLPEYNSK 1039

  Fly  1407 ELLYEKLLLAVEETNTFGI 1425
            |.|.|:||.|:..:..||:
Mosquito  1040 EKLEERLLKAINYSKGFGM 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021	35/172 (20%)
		WW	638..667	CDD:459800	3/31 (10%)
		HECW1_helix	738..794	CDD:465766	14/60 (23%)
		HECTc	1068..1424	CDD:238033	124/367 (34%)
Ube3a	XP_061511705.1	None