DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and Hecw2

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001001883.1	Gene:	Hecw2 / 329152	MGIID:	2685817	Length:	1578	Species:	Mus musculus

Alignment Length:	1538	Identity:	618/1538 - (40%)
Similarity:	784/1538 - (50%)	Gaps:	361/1538 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VPLQPLAASSA-------CLADRSPVDPIAVRLQQEEQAEGDDEEEEEEE-----------EDDD 54
            :|:|.|....|       .|..|.|.|.::..||.:.:......|:...|           ..|.
Mouse   283 IPVQRLLERQAGDQMLSYNLGRRLPADHVSGYLQFKVEVTSSAHEDASPEAVGTILGVHTVNGDL 347

  Fly    55 DDPKEEEAFYEARNGNESDELEQAFQSALTLTNDVHVSVSEVEEHEPPLASRNQEVAEVEEQQQQ 119
            ..|.:||..    .|:..|.         |:..:..||...|.:..|..:.|.....|::.:.
Mouse   348 GSPSDEEDM----PGSHHDS---------TICANGPVSEDSVADGTPKHSFRTSSTLEIDTED-- 397

  Fly   120 LGACALPQPSEASLTGSKETREPRHHQTLLSTKSCETPANNATLSPTNSYNGSIGSDGGSSVGGG 184
                                        |:||.|..:|......| .|.|..:|..:|.:..|..
Mouse   398 ----------------------------LISTSSRNSPPRGRQDS-LNDYLDAIEHNGPARPGAA 433

  Fly   185 ARRKSWTLSPQSGGSTPLSGAKKKTKTGAPTTTLSNANGDGFNLWVARECFETVPAEMVDTLSMA 249
            :.      |.:|.|::|      |.::..||.|..||                          |.
Mouse   434 SS------SERSMGASP------KLRSSFPTDTRLNA--------------------------ML 460

  Fly   250 EVDEEVDEEEDEEAAAVESLLGAAAALQASAHV---QRRQQQQHHQHLRQPSPPQHRPLERSWPP 311
            .:|   .:|||.|   .:..||..::|:....:   .|..:........|..|....|:|..
Mouse   461 HID---SDEEDHE---FQQDLGYPSSLEEEGGLIMCSRASRIDDGSLTSQTKPEDDNPVENE--- 516

  Fly   312 RAVGRDLKLQGDVFQFDILDTDERLAE--EMAQGSGSSNNSPLATPPVRFKPLLKKKIGPDSYIN 374
                       |....:....:|||..  |:|.||     .|.:|.|...:..|:.:...|....
Mouse   517 -----------DASIHETASLEERLENLPEVADGS-----LPSSTAPDENEANLEPQPSADQGST 565

  Fly   375 TI-STQKVPVHQSYEFPTFPSSSAVGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQASPR 438
            .: |:|:|      :.||  |.:..|:|.:|..|            .||.|  :..|.::.:.|.
Mouse   566 ELCSSQEV------DQPT--SGADAGASDTSGGS------------RRAAS--ETESLDQGSEPS 608

  Fly   439 LLLSPKRPRSPPSGCSTRSASPLDISLSPEQHSPTRGRGVG----------------GALQDAVP 487
            .:.|...|..|     .|:.|..:.|..||..|...|....                .:|:.|..
Mouse   609 QVSSETEPSDP-----ARTESVSEASTRPEGESDPEGADSSCNESVTTQLSSVETRCSSLESARF 668

  Fly   488 PGTPTFHGQRPQQRLLKRVGGGAGAG---ATGGATGS-PLVCPPTPTHHARRHARLQAVTANSSL 548
            |.||.|..|..:.        ||.|.   ::|.|.|| ..||.|         :.|.||...|..
Mouse   669 PETPAFSSQEEED--------GACAAEPTSSGPAEGSQESVCTP---------SSLPAVQVPSRE 716

  Fly   549 ASGGAIPSDPPAVSSQLDYIYLQDGGQEQGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAG 613
            ..|.|..:...:...:|..::.:.|..|                        .|||||.||||..
Mouse   717 EEGSAAEAAALSEQGELGEVWQRRGSLE------------------------GAAAAAPAAAATD 757

  Fly   614 AALMEPG-TGTVSGS-SGA-----GAAG--------------------------EPPLPPAWEAR 645
            :...|.| .|...|: .||     ||.|                          :..|||.||||
Mouse   758 SQPQEDGDAGDAQGACEGATAQEEGATGGSQTNGHQPLRSLPSVRQDVSRYQRVDEALPPNWEAR 822

  Fly   646 MDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQ--QLDRRYQSIRRTITNE-------- 700
            :||||||||:||..|||:||||.|.|:.....|....:|  ||:|||||||||:|||
Mouse   823 IDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTSA 887

  Fly   701 ----SRAAQLYN----------LPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNE 751
                ...|..:.          ||.|.:.:..:....:||        :..|..|:|:::||:|.
Mouse   888 IDGAGEEADFHQASADFRRENVLPHSTSRSRLTLLLQSPP--------VKFLISPEFFTVLHSNP 944

  Fly   752 AALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFF 816
            :|..::..|..||||:.::|||...|:|||:|:|||..:|.||....|||..||.|.|..||.||
Mouse   945 SAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFF 1009

  Fly   817 IDHQHRRTSFMDPRLPVECPR---VVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPAS 878
            :||..|.|:|:|||||::..|   .:.|||..::|:|.                ::|.:...  |
Mouse  1010 VDHNSRTTTFIDPRLPLQSSRPTSALVHRQHLTRQRSH----------------SAGEVGED--S 1056

  Fly   879 SVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYED- 942
            ..:|.|.|  |||||:             .||.|                        ...|:|
Mouse  1057 RHAGPPVL--PRPSST-------------FNTVS------------------------RPQYQDM 1082

  Fly   943 VPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQLTILLSL 1007
            ||:|||:|::||||||||||||:|||.....:..|||||..:|.||.|.|.||..|..|.:||||
Mouse  1083 VPVAYNDKIVAFLRQPNILEILQERQPDLARNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLSL 1147

  Fly  1008 FEQEIMGFVPIEE-------RSPQGSPVLN-------SRMPQRAPPPFRRDFEAKLRSFYRKLES 1058
            ||:|||.:||...       :||:||||.:       .|...|||.|::||||||||:||||||:
Mouse  1148 FEEEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLET 1212

  Fly  1059 KGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSR 1123
            |||||||.||||.|||.|||||||.:||..::|||||.:|.|.:..||||||.|||||||||:||
Mouse  1213 KGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSR 1277

  Fly  1124 ELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKAL 1188
            |||||||||||||||||||||:||:||||||.|:|||||||:|||||:|||||||||||||||||
Mouse  1278 ELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKAL 1342

  Fly  1189 LRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINE 1253
            ||:...|||||.||.||||||||::||||...:|  |||.|.||:.|.:.:|||||||.||.:.|
Mouse  1343 LRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILD--LTFTVNEEVFGQITERELKPGGANIPVTE 1405

  Fly  1254 KNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLN 1318
            ||||||:|||:|||:||||.:||||||||||||:|:||||||||||||||||||||||.||||.|
Mouse  1406 KNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLNDWRNN 1470

  Fly  1319 TEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWG 1383
            ||||.||||||.||.|||..:|||:||||||||||||||||||||||::||||.||||||:||||
Mouse  1471 TEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWG 1535

  Fly  1384 KPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            |..||||||||||||||||||:..:||||||.|||||:|||:|
Mouse  1536 KITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	22/28 (79%)
		HECTc	1068..1424	CDD:238033	278/355 (78%)
		HECTc	1092..1423	CDD:214523	261/330 (79%)
Hecw2	NP_001001883.1	HECW_N	45..164	CDD:374632
		C2_NEDL1-like	185..320	CDD:176073	10/36 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..453		30/167 (18%)
		DMP1	<344..700	CDD:369294	100/497 (20%)
		NESP55	<463..639	CDD:115071	50/227 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..802		86/392 (22%)
		Interaction with TP73. /evidence=ECO:0000250	737..1074		132/401 (33%)
		WW	815..844	CDD:366073	22/28 (79%)
		HECW1_helix	921..987	CDD:375862	26/73 (36%)
		WW	993..1022	CDD:366073	15/28 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1030..1075		18/77 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1167..1193		9/25 (36%)
		HECTc	1222..1576	CDD:238033	278/355 (78%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	514	1.000	Domainoid score	I319
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	901	1.000	Inparanoid score	I377
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm42496
orthoMCL	1	0.900	-	-		OOG6_105324
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5820
SonicParanoid	1	1.000	-	-		X1661
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.890