Protein Alignment Hecw and HUWE1

DIOPT Version :10

• Sequence 1: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Alignment Length: 1822
• Identity: 400/1822 - (21%)
• Similarity: 611/1822 - (33%)
• Gaps: 622/1822 - (34%)

  Fly    62 AFYEARNGNESDELEQAFQSALTLTNDVHVSVSEVEEHEPPLASRNQEVAEVEEQQQQLGACALP 126
            |..|..|....|.:......||..:.:|.|.|.      |.:....|:.|:.|:.|..|.....|
  Fly  3491 AALEQLNVTAPDVVRTDRNFALPSSLEVDVDVL------PGIVDLPQQEAQPEDDQLLLPPPPPP 3549

  Fly   127 QPSEAS------------LTGSKETREPRHHQTLLSTKSCE----------TPANNATLSPTNSY 169
            .||:.:            ...|..||| ......::|:|.|          ||.::.:.||
  Fly  3550 PPSDTTPLVHAEDDLWPGTVVSAGTRE-ESSAPAVATESTEAVNESNQPEPTPESSESTSP---- 3609

  Fly   170 NGSIGSDGGSSVGGGARRKSWTLSPQ--SGGSTPLS-GAKKKTKTGA--PTTT---LSNANGDGF 226
                                   :||  |...|||. ||......||  |.||   .|.|...|.
  Fly  3610 -----------------------NPQAPSAEPTPLEPGAAVDASVGAQTPATTEEAASTAGASGT 3651

  Fly   227 NLWVARECFET--------VPAEMVDTLSMAEVDEEVDEEEDEE----------------AAAVE 267
            ...:.....|.        || |.||...:|.:..|:.||..:|                ..|.:
  Fly  3652 TATITDMSPEVRAALGDLEVP-EGVDPSFLAALPSEMREEVIQEHLRMQRIRQRAQQNAIQIAHD 3715

  Fly   268 SLLG------AAAALQASAHV---QRRQQQQHHQHLRQPSPP-------QHRP------------ 304
            ||:.      ||..|...:.|   ||.:||:.......|..|       |:.|
  Fly  3716 SLVEVNPEFLAALPLNIQSEVLMQQRIEQQRQAAQTANPEDPVDTAAFFQNLPENLRQAILTDME 3780

  Fly   305 -----------------LERSW------------PPRAVGRDLKLQGDVFQFDILDTDERLAEEM 340
                             |.|.|            |..|:.|        ||..:...|:......
  Fly  3781 ESQIASLPPELAAEAQFLRRDWESRNGARMDAHPPSNALSR--------FQTTLQSLDDTRWHSS 3837

  Fly   341 AQGSGSSNNSPL---------ATPPVRFKPLLKKKIG------------PDSY------------ 372
            .....|.|..|.         ..|.....|.:.|.:.            |||.
  Fly  3838 IWYDASGNAQPQHHQHTTIVHQHPHAHHAPNMGKPLALLMMEDENILLDPDSLATLLLFLFVEDQ 3902

  Fly   373 -INTISTQKVPVHQSYEFPTFP-----------------SSSAVGSSSSSPNSLQ------FPYL 413
             :|::...:|..:..:..||..                 ::...|.:...|..|:      |.|
  Fly  3903 KVNSMRLHRVIRNLCHHEPTRDWIISALISIIQKTNEDNANFGAGQAGGKPEWLKLRVDAAFGY- 3966

  Fly   414 RQHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSPPSGCSTRSASPLDISLSPEQHSPTRGRGV 478
            :.:..|...|..|.|.|        :.::|:..:.....|       ||:.....:|.|:
  Fly  3967 KSNIFLINRLYEGSARS--------ISINPQAAQMIVRNC-------LDLLFVLAKHYPS----- 4011

  Fly   479 GGALQDAVPPGTPTFHGQRPQQRLLKRV----------GGGAGAG--ATGGATGSPLVCPPTPTH 531
                 ..||     |:.....:|:|..|          |||||:|  |:||.||...|.|.....
  Fly  4012 -----SFVP-----FNRDVKARRILSAVFGMPSPTAGSGGGAGSGSAASGGLTGYDDVPPGGTLD 4066

  Fly   532 HARRHARLQAVTANSSL-----ASGGAIPSD-PPAVSS---------------------QLDY-- 567
            ...|..|.|.|....|:     |...::|.| .|:.|.                     .:.|
  Fly  4067 FRSRFCRYQVVNRLRSIFDDHPAPKPSVPLDEAPSTSKAAAAKAAATAKVSTAGSQNKHSVPYQT 4131

  Fly   568 -------IYLQDGGQEQ----------------------------------GQ------------ 579
                   :.|....|.|                                  ||
  Fly  4132 NAKNFWDVVLNIDQQTQVRLANVAQFPLTSQPAWEWQPNTADFLSFSESPFGQLLEMLPYKVICR 4196

  Fly   580 -------------------EQSDEVVHISSTRLPSIP----ERSAAAAAA-------------AA 608
                               .:.:|::.:|....|.:|    :|:.|||||             |.
  Fly  4197 SPHLTDMLVKLLASLSTELPKEEELLPLSDQMPPLVPIGPVQRAGAAAAAAHPPPPQPPAENTAT 4261

  Fly   609 AAAAG---AALME----PGTGT-VSGSSGAGAAGEP--------PLPPAWEARMDSHGRIF---- 653
            |...|   ||.:|    |.:|. .||.|.|||....        |:.|: :.|...:.:.|
  Fly  4262 ATEIGDGLAANIEEQASPASGNPASGDSNAGAKRTQLPTLSVALPVTPS-KPRRKIYSKNFSQLQ 4325

  Fly   654 ----YIDHTTRTTSW---------------QRPGAA----PSGGPAGREQHHRQQLDRRYQSIRR 695
                .:.|...||..               |...|.    .:....|..:..||.:        :
  Fly  4326 LVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASSAIFIQYLTAAILGLAEEVRQAI--------Q 4382

  Fly   696 TITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRN 760
            .:.||.|...::.......|.|.||:.||...|:.: |.:      ...|||........|....
  Fly  4383 MLLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYV-PTV------SGASLLPNLAVHEGIMQDR 4440

  Fly   761 AALKHMVMRIRRD--PPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRR 823
            ...:|:::...::  |.|                    ..:|||..:...:.|.:.:|:     |
  Fly  4441 FTAEHVIISAPKNAKPTC--------------------ELQLPSMKKLMSNSSAQPYFL-----R 4480

  Fly   824 T--SFMDPRLPVECPRVVRHRQQHSQQQS---------SVGYYYPDLV----DGNCLSATSGHIN 873
            |  .||            :.|..:..|..         ..|....|::    ||.....:|..:.
  Fly  4481 TLKIFM------------QVRDMYEAQNGLSTGGGVACGAGDNDDDIIDIEGDGGASGGSSSDMA 4533

  Fly   874 ASPASSVSGVPPLPPPR-------PSSSSSSSRSSHGHGHNC----------------------N 909
            ...||::|..||:...:       .......:||..|.|::.                      |
  Fly  4534 PGSASTISPPPPMETNQIAQDGDDDEEDDDEARSFPGVGNHAVASASKSTKPTLSQILCLDVLWN 4598

  Fly   910 TTSAISCALNADRSAY--------------------------------GAAGM---ASAGATAAG 939
            |.|....||...:..:                                .|||.   |:|||.|.|
  Fly  4599 TLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIG 4663

  Fly   940 ---------------YEDVPIAYNEKVIAFLRQPNILE------ILRERQGQHTMSRQLREKINI 983
                           .:||..|......:|..:|.:.:      ::........||
  Fly  4664 GLGAAAPSAQEYSPFMDDVSSANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMS--------- 4719

  Fly   984 LRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQR----APPPFR-- 1042
                        .|:.||       .|:...|:...|:.   ..|||..:.|.    :..||.
  Fly  4720 ------------AHEAQL-------RQDRQKFLQFAEKH---RTVLNQILRQSPTHLSDGPFAVL 4762

  Fly  1043 ------RDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVL 1101
                  .||:.|.:.|..:||....|....:..:.:||..:.||:||.:.....:: .:.|..::
  Fly  4763 VDHTRILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEE-WKNRFYIV 4826

  Fly  1102 WDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVL 1166
            ::.|||.|.||..||::.::|||:|||.|.||..|..|..|..::|.|....|...:|:|.|||:
  Fly  4827 FEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVI 4891

  Fly  1167 GLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLG--LTFCV 1229
            ..|:....||:.:|||.|||.:|...|..:|:||.|.||::.|.::..|||.|   ||  |||..
  Fly  4892 AKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDIST---LGYELTFST 4953

  Fly  1230 TEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSV 1294
            ..:..|....|:|||.|::..:.|:||.||::.:.:.::...:::|.::.:.|||::|...|:|:
  Fly  4954 EVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISI 5018

  Fly  1295 FDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSS 1359
            |:.:||||:|:|..:||..|.:.||||.. |......|.|||:.:..|....|.:.||||||||.
  Fly  5019 FNEQELELLISGLPDIDIEDLKANTEYHK-YTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSK 5082

  Fly  1360 IPYEGFSALRGSTGPRRFCIEKWGK-PNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEE-TNT 1422
            :|.:||.:|.|..|.::|.|.:..: .:.||.||||||:||||.|.:.:.|...||.|:.| :..
  Fly  5083 VPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEG 5147

  Fly  1423 FG 1424
            ||
  Fly  5148 FG 5149

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021	40/168 (24%)
		WW	638..667	CDD:459800	7/51 (14%)
		HECW1_helix	738..794	CDD:465766	7/57 (12%)
		HECTc	1068..1424	CDD:238033	135/359 (38%)
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521	46/214 (21%)
		UBM	3670..3700	CDD:464159	10/30 (33%)
		UBM	3719..3746	CDD:464159	7/26 (27%)
		HECTc	4796..5149	CDD:238033	135/357 (38%)