DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and smurf1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001001943.1	Gene:	smurf1 / 321695	ZFINID:	ZDB-GENE-040426-2744	Length:	731	Species:	Danio rerio

Alignment Length:	881	Identity:	253/881 - (28%)
Similarity:	359/881 - (40%)	Gaps:	281/881 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   555 PSDPPAVSSQLDYIYLQDGGQEQGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEP 619
            |||..||..|:                           :.|:..|....:........|  |:|
Zfish   123 PSDSDAVRGQI---------------------------VVSLQTRDRIGSGGPVVDCRG--LVE- 157

  Fly   620 GTGTVSGSSGAG----AAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQ 680
            ..|.|...||.|    ...|.|:|              |.|.|         |||..|.....|.
Zfish   158 NEGPVFEDSGPGRPLSCFMEEPMP--------------YTDPT---------GAAGGGNCRALES 199

  Fly   681 HHRQQLDRRYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYS 745
            .:::|   |.|:.|  |.|:......:......:.:.:...|......|.:...:.
Zfish   200 PNQEQ---RLQAQR--IRNQDSRGHTHTPQNRPHGHQSPDLPEGYEQRTTVQGQVY--------- 250

  Fly   746 LLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQ 810
            .|||.......::         .||.||               |.:...:....||...|.:...
Zfish   251 FLHTQTGVSTWHD---------PRIPRD---------------LNSVSCEELGPLPPGREIRSTV 291

  Fly   811 SGKQFFIDHQHRRTSFMDPRLPVECPRVVRH-RQQHSQQQSSVGYYYPDLVDGNCLSATSGHINA 874
            ||:.:|:||.:|.|.|.||||        .| ..||||.:.|                    ..|
Zfish   292 SGRIYFVDHNNRTTQFTDPRL--------HHIMSQHSQVKES--------------------SQA 328

  Fly   875 SPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAG 939
            .|.....|:                 ..|.|
Zfish   329 LPVQMEVGM-----------------EEGDG---------------------------------- 342

  Fly   940 YEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQLTIL 1004
              ::|:.|                          .|.|.:|:.:||           |:|.|
Zfish   343 --ELPVRY--------------------------ERDLVQKLKVLR-----------HELSL--- 365

  Fly  1005 LSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLK 1069
                            :.||..                                        ..:
Zfish   366 ----------------QQPQAG----------------------------------------HCR 374

  Fly  1070 LHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFE 1134
            :.:.|..:.|:::|:||....|||:: ||.|.:..||||||||.:||:.:||..|:.|||||||:
Zfish   375 IEVSREEIFEESYRQIMKMRPKDLKK-RLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQ 438

  Fly  1135 YSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLE 1199
            ||.::.||:|::|.|:...:...:|.|.||::|||:.|.:.::..||.||||.||..|:.|.|||
Zfish   439 YSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTLPFYKQLLGKPIQLCDLE 503

  Fly  1200 SLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMI 1264
            ::|.|.|:||.||.:|||.:.:|  .||||.....|..:..||||.||||.:.|:|||||:...:
Zfish   504 TVDPELHKSLVWILENDITSVLD--HTFCVEHNAFGKFLQHELKPNGKNIPVTEENKKEYVRLYV 566

  Fly  1265 KWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNH 1329
            .||..||::.|..:|.:||.|:|...|:..||.:||||:|.|..:||.|||:.||..:....|::
Zfish   567 NWRFMRGIEAQFLALQKGFNELIPQHLLKPFDNKELELIIGGLGKIDLNDWKANTRLKHCVADSN 631

  Fly  1330 QVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGST---GPRRFCIEKW-GKPNALPR 1390
             ::.||||.:|.|..|:|.||||||||::.:|.:||.||:|||   |||.|.|... ...:.||:
Zfish   632 -IVKWFWQAVESFDEERRGRLLQFVTGSTRVPLQGFKALQGSTGSAGPRLFTIHLIDANTDNLPK 695

  Fly  1391 AHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            |||||||:|:|||.:.|.||||||.|||||..|.:|
Zfish   696 AHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	4/28 (14%)
		HECTc	1068..1424	CDD:238033	170/359 (47%)
		HECTc	1092..1423	CDD:214523	164/334 (49%)
smurf1	NP_001001943.1	C2_Smurf-like	14..138	CDD:176028	7/41 (17%)
		WW	234..266	CDD:197736	5/49 (10%)
		WW	280..312	CDD:197736	13/31 (42%)
		HECTc	373..728	CDD:238033	170/358 (47%)
		HECTc	397..728	CDD:214523	164/334 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810