Protein Alignment CG42797 and Trip12

DIOPT Version :9

• Sequence 1: NP_572574.2
• Gene: CG42797 / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_038939619.1
• Gene: Trip12 / 316575
• RGDID: 1306607
• Length: 2074
• Species: Rattus norvegicus
• Alignment Length: 2094
• Identity: 391/2094 - (18%)
• Similarity: 633/2094 - (30%)
• Gaps: 826/2094 - (39%)

  Fly    38 QAEGDDEEEEEEEEDDDDDPKEEEA---------FYEARNGNESDELEQAFQSALTLTNDVHVSV 93
            |.|..|.....|.:.....||::.:         .|...|...|.:..:|||...:|:
  Rat    87 QPEDPDRANTSERQKTGQVPKKDNSRGVKRSASPDYNRTNSPSSAKKPRAFQHIESLS------- 144

  Fly    94 SEVEEHEPPLASRNQEVAEVEEQQQQLGACALPQPSEA-------------------------SL 133
               |.::||..|:.:.:    :|:|||.:..||..|:|                         |.
  Rat   145 ---ETNKPPSKSKKRHL----DQEQQLKSAQLPSTSKAHTRKSVAAGSSRSQKRKRTESSCVKSG 202

  Fly   134 TGSKET--REPRHHQTLLSTKS-------CETPANNATLSPTNSYNGSIGSDGGSSVGGGAR--- 186
            :||:.|  .|.....|.|::||       |.|..::::.:.|:|.:.::.| ..|:|..|||
  Rat   203 SGSESTGAEERSAKPTKLASKSATSAKAGCSTITDSSSAASTSSSSSAVAS-ASSTVPAGARVKQ 266

  Fly   187 ----------RKSWTLSP----------QSGGSTPLSGAKK--------KTKTGAPTTTLSNANG 223
                      |.:.:.||          ::|||:....|.:        |||...|.::.|..:.
  Rat   267 GKDQNKARRSRSASSPSPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETSK 331

  Fly   224 DGFNLWVA---------RECFETVPAEMVD---------TLSMAEV------------------D 252
            .|.:...|         ::..|:.|||:..         |.|.|..                  :
  Rat   332 PGPSGLQAKLASLRKSTKKRSESPPAELPSLRRSTRQKTTGSCASTSRRGSGLGKRGAAEARRQE 396

  Fly   253 EEVDEEEDEE---------------AAAVESLLGAAAALQASAHVQRRQQQQHHQHLRQPSPPQH 302
            :..|.|.::|               |||..|:.||.....:........:....|.|.:
  Rat   397 KMADPEGNQETVNSSAARTDEAPQGAAASSSVAGAVGMTTSGESESDDSEMGRLQALLE------ 455

  Fly   303 RPLERSWPPRAVGRDLKLQGDVFQFDILDTDERLAEEMAQGSGSSNNSPLATPPVRFKPLL---- 363
               .|..||...|........:|...|.......|:::.||..:|:.|......:....||
  Rat   456 ---ARGLPPHLFGPLGPRMSQLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGN 517

  Fly   364 KKKIG---PDSYINTISTQKVPVHQ-----------SYEFPTFPSSSAV---------------- 398
            ::.:|   ..|.:..:.|.....|.           :|.....|.||||
  Rat   518 EETLGGFPVKSVVPALITLLQMEHNFDIMNHACRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQ 582

  Fly   399 --------------------------------------GSSSSSPNSL-------------QFPY 412
                                                  .|.::..|:|             :|.:
  Rat   583 CIDVAEQALTALEMLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHF 647

  Fly   413 LRQHRP-LTRALSNGKASSSE---------------------EQASPRLLLSPKR--PRSPP--- 450
            :....| ||:.|::....|.|                     :.||..||.:.::  ..:||
  Rat   648 VADSLPLLTQRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTPPILS 712

  Fly   451 ---------------SGCSTRSASPLDIS---LSPEQHSPTRGRGVGGALQ--DAVPPGTPTFHG 495
                           |.|.|.:...:..|   ::...|....|...|...:  |.||
  Rat   713 SGMFIMVVRMFSLMCSNCPTLAVQLMKQSFTDIAETLHFLLCGASNGSCQEQIDLVP-------- 769

  Fly   496 QRPQQ------------------------RLLKRVGGGAGAGATGGA------------------ 518
            :.||:                        .:||:    ..|..|.||
  Rat   770 RSPQELYELTSLICELMPCLPKEGIFAVDTMLKK----GNAQNTDGAIWQWRDDRGLWHPYNRID 830

  Fly   519 ----------------------------------------TGSPLVCPPTPTHHA---------R 534
                                                    |...:...|.|..:.         :
  Rat   831 SRIIEVAAHQVGEDEISLSTLGRVYTIDFNSMQQINEDTGTARAIQRKPNPLANTNTSGYSDLKK 895

  Fly   535 RHARLQAVTANSSLASG------GAI-----PSDPPAVSSQ-----LDYIYLQDGGQEQGQEQSD 583
            ..||.|.:..:..||..      |.:     .|..|||..:     |..||..|.      |...
  Rat   896 DDARAQLMKEDPELAKSFIKTLFGVLYEVYSSSAGPAVRHKCLRAILRIIYFADA------ELLK 954

  Fly   584 EVV-------HISS---------------------TRLPSI----PERSAAAAAAAAAAAAGAAL 616
            :|:       ||:|                     .:||.|    ..|..........|.:.:.|
  Rat   955 DVLKNHAVSSHIASMLSSQDLKIVVGALQMAEILMQKLPDIFSVYFRREGVMHQVKHLAESESLL 1019

  Fly   617 MEP------GTG----TVSGSSGAGAA--------GEPPLPPAWEARMD--SHGRIFYIDHTTRT 661
            ..|      |:|    |...|||...|        |.|.|..:.:..:|  ..||:..:....|
  Rat  1020 TSPPKACTNGSGSLGSTTPASSGTATAATNASADLGSPSLQHSRDDSLDLSPQGRLSDVLKRKR- 1083

  Fly   662 TSWQRPGAAPSGGPAGREQHHRQQLDRRY--QSIRRTITNESRAAQLYNL------PTSANSNAN 718
                    .|..||. |.::...:.|.:.  |:...|.|...:::.|.:|      ..||.||:|
  Rat  1084 --------LPKRGPR-RPKYSPPRDDDKVDNQAKSPTTTQSPKSSFLASLNPKTWGRLSAQSNSN 1139

  Fly   719 STAPAAPPPATAI----------------------------------------HPAILML----- 738
            :..||.....:.:                                        :||:.:|
  Rat  1140 NIEPARTAGVSGLARAASKDTISNNREKIKGWIKEQAHKFVERYFSSENMDGSNPALNVLQRLCA 1204

  Fly   739 --------------CRPDFYSLLHTNEAA------------LAIYNRNAALKHMVMRIRRDPPCF 777
                          |..:..|::..::.:            |.:|..:.:.|..|.|..|    .
  Rat  1205 ATEQLNLQVDGGAECLVEIRSIVSESDVSSFEIQHSGFVKQLLLYLTSKSEKDAVSREIR----L 1265

  Fly   778 QRYQY--------------------NKDLVALV----NTFAQMSR------ELPSCWETKLDQSG 812
            :|:.:                    :..|:|||    |..:||.:      :.||.     :.||
  Rat  1266 KRFLHVFFSSPLPGEEPVGRVEPVGHAPLLALVHKMNNCLSQMEQFPVKVHDFPSG-----NGSG 1325

  Fly   813 KQFFIDHQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPA 877
            ..|.::...:...|.:.. .::| ::.||               ||.  .|......|.:...|.
  Rat  1326 GSFSLNRGSQALKFFNTH-QLKC-QLQRH---------------PDC--ANVKQWKGGPVKIDPL 1371

  Fly   878 SSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATA----- 937
            :.|..:......|........|.......:..:...|..:|        ||...::|...
  Rat  1372 ALVQAIERYLVVRGIFRYGRVREDDEDSDDDGSDEEIDESL--------AAQFLNSGNVRHRLQF 1428

  Fly   938 -AGYEDVPIAYNEKVIAFLRQPNI-LEILRE----------RQG----QHTM-SRQLREKINIL- 984
             .|...:|  ||..|...:||.:: .|..||          |.|    .||: .:.:||.....
  Rat  1429 YIGEHLLP--YNMTVYQAVRQFSVQAEDERESTDDESNPLGRAGIWTKTHTIWYKPVREDEESSK 1491

  Fly   985 --------RVEGVPAL---------ERLGHD----------------------------LQLTIL 1004
                    |.:..|..         :.|.||                            |.:.:|
  Rat  1492 DCVGGKRGRAQTAPTKTSPRNAKKHDELWHDGVCPSVANPLEVYLIPTPPENITFEDPSLDVILL 1556

  Fly  1005 LSLFE---------------QEIMGFVPIEERSPQGSPVLNSRMPQRA---------------PP 1039
            |.:..               :||   :|..|       .:||::..:|               |.
  Rat  1557 LRVLHAISRYWYYLYDNAMCKEI---IPTSE-------FINSKLTAKANRQLQDPLVIMTGNIPT 1611

  Fly  1040 ---------PFRRDFEAKLRSFY--------------------RKLESKGYGQGPH--KLKLHIR 1073
                     ||...|:.:...||                    .:.:|:.....|.  :.|..:.
  Rat  1612 WLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSRVAPRLDRKKRTVN 1676

  Fly  1074 RSHLLEDAFRRIMSANKKDL--QRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLF--- 1133
            |..||:.| ..:|    :||  .|..|.:.::.|.|... ||:.||:.|:|:||.....||:
  Rat  1677 REELLKQA-ESVM----QDLGSSRAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGE 1735

  Fly  1134 -------EYSANDTYTVQ------VSPLS-----AFVDNCHDWFRFSGRVLGLALVHQYLLDAFF 1180
                   :.|...|..:|      ..|..     |.:......|||.|:::..|::...|:|...
  Rat  1736 EVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPL 1800

  Fly  1181 TRPFYKALLRLPVALS--DLESLD-----NEFH-------------------QSLQWIRDNDIGT 1219
            ..||||.:||...:|:  ||..:|     :.:|                   :|||:..:.....
  Rat  1801 GLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMN 1865

  Fly  1220 GV---DLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVR 1281
            |.   ||||.|     .|....:.|||.|||:|.:...|.:|||..:|.|.|..||..|.:|...
  Rat  1866 GCSVEDLGLDF-----TLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVCRQFDSFRD 1925

  Fly  1282 GFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYR-----SGYHDNHQVIVWFWQVIER 1341
            ||..|.....:..|...||:.::.| ::.||  |...|...     .||..:.:.:.:.::::..
  Rat  1926 GFESVFPLSHLQYFYPEELDQLLCG-SKADT--WDAKTLMECCRPDHGYTHDSRAVKFLFEILSS 1987

  Fly  1342 FSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKP-NALPRAHTCFNRLDLPPYPT 1405
            |.|||:...||||||:..:|..||.:|.......|...|....| :.||...||.|.|.||.|.:
  Rat  1988 FDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSS 2052

  Fly  1406 PELLYEKLLLAVEE 1419
            .|::.:|||:|..|
  Rat  2053 IEIMRDKLLIAARE 2066

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	5/30 (17%)
		HECTc	1068..1424	CDD:238033	118/410 (29%)
		HECTc	1092..1423	CDD:214523	112/386 (29%)
Trip12	XP_038939619.1	SRP1	489..>714	CDD:227396	32/224 (14%)
		WWE	814..876	CDD:397111	1/61 (2%)
		HECTc	1672..2072	CDD:238033	118/409 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900