DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and Hecw2

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001101688.1	Gene:	Hecw2 / 316395	RGDID:	1593244	Length:	1578	Species:	Rattus norvegicus

Alignment Length:	1550	Identity:	609/1550 - (39%)
Similarity:	770/1550 - (49%)	Gaps:	385/1550 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VPLQPLAASSAC--------LADRSPVDPIAVRLQQEEQAEGDDEEEEEEE-------------- 50
            :|:|.|....|.        |..|.|.|.::..||...:.....:|:...|
  Rat   283 IPVQRLLERQAVGDQMLSYNLGRRLPADHVSGYLQFRVEVPSSAQEDASPEAVGTILGVHTVNGD 347

  Fly    51 ----EDDDDDPKEEEAFYEARNGNESDELEQAFQSALTLTNDVHVSVSEVEEHEPPLASRNQEVA 111
                .||:|.|           |:..|.         |:..:..||...|.:..|..:.|.....
  Rat   348 LGSPSDDEDMP-----------GSHHDS---------TICANGPVSEDSVADGTPKHSFRTSSTL 392

  Fly   112 EVEEQQQQLGACALPQPSEASLTGSKETREPRHHQTLLSTKSCETPANNATLSPTNSYNGSIGSD 176
            |::.:.                              |:||.|..:|......| .|.|..:|..:
  Rat   393 EIDTED------------------------------LISTSSRNSPPRGRQDS-LNDYLDAIEHN 426

  Fly   177 GGSSVGGGARRKSWTLSPQSGGSTPLSGAKKKTKTGAPTTTLSNANGDGFNLWVARECFETVPAE 241
            |.|..|           ..|....|: ||..|.::..||.|..||
  Rat   427 GPSRPG-----------TASSSERPM-GASPKLRSSFPTDTRLNA-------------------- 459

  Fly   242 MVDTLSMAEVDEEVDEEEDEEAAAVESLLGAAAALQASAHV---QRRQQQQHHQHLRQPSPPQHR 303
                  |..:|   .:|||.:   .:..||..::|:....:   .|..:........|..|....
  Rat   460 ------MLHID---SDEEDHD---FQQDLGYPSSLEEEGGLIMCSRTSRIDDGSLTSQTKPEDDN 512

  Fly   304 PLERSWPPRAVGRDLKLQGDVFQFDILDTDERLAE--EMAQGSGSSNNSPLATPPVRFKPLLKKK 366
            |:|..              |....:....:||...  |:..||..|..:|...         :..
  Rat   513 PVENE--------------DASVHETASLEERPENLPEVEDGSLPSGTAPDEN---------EAS 554

  Fly   367 IGPDSYINTISTQKVPVHQSYEFPTFPSSSAVGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSS 431
            :.|....:..||: :...|..:.||  |.:..|:|.:|..|            .||.|  :..|.
  Rat   555 VEPQPSADQGSTE-LCSSQEVDQPT--SGTDAGASDTSVGS------------RRAAS--ETESL 602

  Fly   432 EEQASPRLLLSPKRPRSPPSGCSTRSASPLDISLSPEQHSPTRGRGVG----------------G 480
            ::.:.|..:.|...|..|     .|:.|..:.|..||..|...|....                .
  Rat   603 DQGSEPSQVSSETEPSDP-----ARTESVSEASTRPEGESDLEGADSSCNESVTTQLSSVETRCS 662

  Fly   481 ALQDAVPPGTPTFHGQRPQQRLLKRVGGGA------GAGATGGATGSPLVCPPTPTHHARRHARL 539
            :|:.|..|.||.|..|..:.        ||      .:|.|.|:..|  ||.|         ..|
  Rat   663 SLESARFPETPAFSSQEEED--------GACAAEPTSSGPTEGSQES--VCTP---------GSL 708

  Fly   540 QAVTANSSLASGGAIPSDPPAVSSQLDYIYLQDGGQEQGQEQSDEVVHISSTRLPSIPERSAAAA 604
            .||...|....|....:...:...:|..::.:.|..|                       .||||
  Rat   709 PAVQVPSREEEGSGAEATALSEQGELGEVWQRRGSLE-----------------------GAAAA 750

  Fly   605 AAAAA----------------AAAGAALMEPGTGTVSGSSGAGAAGEPP---------------- 637
            |.|||                |..||...|.|     .:.|:...|..|
  Rat   751 ATAAATDSQPQEDGDPGDTQGACEGATAQEEG-----ATGGSQTNGHQPLRSLPSVRQDVSRYQR 810

  Fly   638 ----LPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQ--QLDRRYQSIRRT 696
                |||.||||:||||||||:||..|||:||||.|.|:.....|....:|  ||:|||||||||
  Rat   811 VDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRT 875

  Fly   697 ITNE------------SRAAQLYN----------LPTSANSNANSTAPAAPPPATAIHPAILMLC 739
            :|||            ...|..:.          ||.|.:.:..:....:||        :..|.
  Rat   876 MTNERPEENTSAIDGAGEEADFHQASADFRRENVLPHSTSRSRLTLLLQSPP--------VKFLI 932

  Fly   740 RPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCW 804
            .|:|:::||:|.:|..::..|..||||:.::|||...|:|||:|:|||..:|.||....|||..|
  Rat   933 SPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFANKQLELPRGW 997

  Fly   805 ETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPR---VVRHRQQHSQQQSSVGYYYPDLVDGNCLS 866
            |.|.|..||.||:||..|.|:|:|||||::..|   .:.|||..::|:|.
  Rat   998 EMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHRQHLTRQRSH--------------- 1047

  Fly   867 ATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMA 931
             ::|.:...  |..:|.|.|  |||:|:             .||.|
  Rat  1048 -SAGEVGED--SRHAGPPVL--PRPAST-------------FNTVS------------------- 1075

  Fly   932 SAGATAAGYED-VPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERL 995
                 ...|:| ||:|||:|::||||||||||||:|||.....:..|||||..:|.||.|.|.||
  Rat  1076 -----RPQYQDMVPVAYNDKIVAFLRQPNILEILQERQPDLARNHSLREKIQFIRTEGTPGLVRL 1135

  Fly   996 GHDLQLTILLSLFEQEIMGFVPIEE-------RSPQGSPVLN-------SRMPQRAPPPFRRDFE 1046
            ..|..|.:||||||:|||.:||...       :||:||||.:       .|...|||.|::||||
  Rat  1136 SSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFE 1200

  Fly  1047 AKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYG 1111
            ||||:||||||:|||||||.||||.|||.|||||||.:||..::|||||.:|.|.:..||||||.
  Rat  1201 AKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYS 1265

  Fly  1112 GPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLL 1176
            |||||||||:|||||||||||||||||||||||:||:||||||.|:|||||||:|||||:|||||
  Rat  1266 GPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLL 1330

  Fly  1177 DAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRE 1241
            ||||||||||||||:...|||||.||.||||||||::||||...:|  |||.|.||:.|.:.:||
  Rat  1331 DAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILD--LTFTVNEEVFGQITERE 1393

  Fly  1242 LKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAG 1306
            |||||.||.:.|||||||:|||:|||:||||.:||||||||||||:|:|||||||||||||||||
  Rat  1394 LKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAG 1458

  Fly  1307 TAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGS 1371
            |||||.||||.|||||.||||||.||.|||..:|||:||||||||||||||||||||||::||||
  Rat  1459 TAEIDLNDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGS 1523

  Fly  1372 TGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            .||||||:|||||..||||||||||||||||||:..:||||||.|||||:|||:|
  Rat  1524 NGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	22/28 (79%)
		HECTc	1068..1424	CDD:238033	278/355 (78%)
		HECTc	1092..1423	CDD:214523	261/330 (79%)
Hecw2	NP_001101688.1	HECW_N	45..162	CDD:406866
		C2_NEDL1-like	185..321	CDD:176073	10/37 (27%)
		MDN1	<396..741	CDD:227596	91/483 (19%)
		NESP55	<464..632	CDD:115071	42/218 (19%)
		WW	815..844	CDD:395320	22/28 (79%)
		HECW1_helix	921..987	CDD:408233	26/73 (36%)
		WW	993..1024	CDD:197736	17/30 (57%)
		HECTc	1222..1576	CDD:238033	278/355 (78%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	514	1.000	Domainoid score	I304
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	897	1.000	Inparanoid score	I366
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm44561
orthoMCL	1	0.900	-	-		OOG6_105324
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1661
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.860