DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hecw and Hecw2

DIOPT Version :10

Sequence 1:NP_572574.2 Gene:Hecw / 31905 FlyBaseID:FBgn0261931 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_001101688.1 Gene:Hecw2 / 316395 RGDID:1593244 Length:1578 Species:Rattus norvegicus


Alignment Length:1550 Identity:609/1550 - (39%)
Similarity:770/1550 - (49%) Gaps:385/1550 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 VPLQPLAASSAC--------LADRSPVDPIAVRLQQEEQAEGDDEEEEEEE-------------- 50
            :|:|.|....|.        |..|.|.|.::..||...:.....:|:...|              
  Rat   283 IPVQRLLERQAVGDQMLSYNLGRRLPADHVSGYLQFRVEVPSSAQEDASPEAVGTILGVHTVNGD 347

  Fly    51 ----EDDDDDPKEEEAFYEARNGNESDELEQAFQSALTLTNDVHVSVSEVEEHEPPLASRNQEVA 111
                .||:|.|           |:..|.         |:..:..||...|.:..|..:.|.....
  Rat   348 LGSPSDDEDMP-----------GSHHDS---------TICANGPVSEDSVADGTPKHSFRTSSTL 392

  Fly   112 EVEEQQQQLGACALPQPSEASLTGSKETREPRHHQTLLSTKSCETPANNATLSPTNSYNGSIGSD 176
            |::.:.                              |:||.|..:|......| .|.|..:|..:
  Rat   393 EIDTED------------------------------LISTSSRNSPPRGRQDS-LNDYLDAIEHN 426

  Fly   177 GGSSVGGGARRKSWTLSPQSGGSTPLSGAKKKTKTGAPTTTLSNANGDGFNLWVARECFETVPAE 241
            |.|..|           ..|....|: ||..|.::..||.|..||                    
  Rat   427 GPSRPG-----------TASSSERPM-GASPKLRSSFPTDTRLNA-------------------- 459

  Fly   242 MVDTLSMAEVDEEVDEEEDEEAAAVESLLGAAAALQASAHV---QRRQQQQHHQHLRQPSPPQHR 303
                  |..:|   .:|||.:   .:..||..::|:....:   .|..:........|..|....
  Rat   460 ------MLHID---SDEEDHD---FQQDLGYPSSLEEEGGLIMCSRTSRIDDGSLTSQTKPEDDN 512

  Fly   304 PLERSWPPRAVGRDLKLQGDVFQFDILDTDERLAE--EMAQGSGSSNNSPLATPPVRFKPLLKKK 366
            |:|..              |....:....:||...  |:..||..|..:|...         :..
  Rat   513 PVENE--------------DASVHETASLEERPENLPEVEDGSLPSGTAPDEN---------EAS 554

  Fly   367 IGPDSYINTISTQKVPVHQSYEFPTFPSSSAVGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSS 431
            :.|....:..||: :...|..:.||  |.:..|:|.:|..|            .||.|  :..|.
  Rat   555 VEPQPSADQGSTE-LCSSQEVDQPT--SGTDAGASDTSVGS------------RRAAS--ETESL 602

  Fly   432 EEQASPRLLLSPKRPRSPPSGCSTRSASPLDISLSPEQHSPTRGRGVG----------------G 480
            ::.:.|..:.|...|..|     .|:.|..:.|..||..|...|....                .
  Rat   603 DQGSEPSQVSSETEPSDP-----ARTESVSEASTRPEGESDLEGADSSCNESVTTQLSSVETRCS 662

  Fly   481 ALQDAVPPGTPTFHGQRPQQRLLKRVGGGA------GAGATGGATGSPLVCPPTPTHHARRHARL 539
            :|:.|..|.||.|..|..:.        ||      .:|.|.|:..|  ||.|         ..|
  Rat   663 SLESARFPETPAFSSQEEED--------GACAAEPTSSGPTEGSQES--VCTP---------GSL 708

  Fly   540 QAVTANSSLASGGAIPSDPPAVSSQLDYIYLQDGGQEQGQEQSDEVVHISSTRLPSIPERSAAAA 604
            .||...|....|....:...:...:|..::.:.|..|                       .||||
  Rat   709 PAVQVPSREEEGSGAEATALSEQGELGEVWQRRGSLE-----------------------GAAAA 750

  Fly   605 AAAAA----------------AAAGAALMEPGTGTVSGSSGAGAAGEPP---------------- 637
            |.|||                |..||...|.|     .:.|:...|..|                
  Rat   751 ATAAATDSQPQEDGDPGDTQGACEGATAQEEG-----ATGGSQTNGHQPLRSLPSVRQDVSRYQR 810

  Fly   638 ----LPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQ--QLDRRYQSIRRT 696
                |||.||||:||||||||:||..|||:||||.|.|:.....|....:|  ||:|||||||||
  Rat   811 VDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRT 875

  Fly   697 ITNE------------SRAAQLYN----------LPTSANSNANSTAPAAPPPATAIHPAILMLC 739
            :|||            ...|..:.          ||.|.:.:..:....:||        :..|.
  Rat   876 MTNERPEENTSAIDGAGEEADFHQASADFRRENVLPHSTSRSRLTLLLQSPP--------VKFLI 932

  Fly   740 RPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCW 804
            .|:|:::||:|.:|..::..|..||||:.::|||...|:|||:|:|||..:|.||....|||..|
  Rat   933 SPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFANKQLELPRGW 997

  Fly   805 ETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPR---VVRHRQQHSQQQSSVGYYYPDLVDGNCLS 866
            |.|.|..||.||:||..|.|:|:|||||::..|   .:.|||..::|:|.               
  Rat   998 EMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHRQHLTRQRSH--------------- 1047

  Fly   867 ATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMA 931
             ::|.:...  |..:|.|.|  |||:|:             .||.|                   
  Rat  1048 -SAGEVGED--SRHAGPPVL--PRPAST-------------FNTVS------------------- 1075

  Fly   932 SAGATAAGYED-VPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERL 995
                 ...|:| ||:|||:|::||||||||||||:|||.....:..|||||..:|.||.|.|.||
  Rat  1076 -----RPQYQDMVPVAYNDKIVAFLRQPNILEILQERQPDLARNHSLREKIQFIRTEGTPGLVRL 1135

  Fly   996 GHDLQLTILLSLFEQEIMGFVPIEE-------RSPQGSPVLN-------SRMPQRAPPPFRRDFE 1046
            ..|..|.:||||||:|||.:||...       :||:||||.:       .|...|||.|::||||
  Rat  1136 SSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFE 1200

  Fly  1047 AKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYG 1111
            ||||:||||||:|||||||.||||.|||.|||||||.:||..::|||||.:|.|.:..||||||.
  Rat  1201 AKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYS 1265

  Fly  1112 GPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLL 1176
            |||||||||:|||||||||||||||||||||||:||:||||||.|:|||||||:|||||:|||||
  Rat  1266 GPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLL 1330

  Fly  1177 DAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRE 1241
            ||||||||||||||:...|||||.||.||||||||::||||...:|  |||.|.||:.|.:.:||
  Rat  1331 DAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILD--LTFTVNEEVFGQITERE 1393

  Fly  1242 LKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAG 1306
            |||||.||.:.|||||||:|||:|||:||||.:||||||||||||:|:|||||||||||||||||
  Rat  1394 LKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAG 1458

  Fly  1307 TAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGS 1371
            |||||.||||.|||||.||||||.||.|||..:|||:||||||||||||||||||||||::||||
  Rat  1459 TAEIDLNDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGS 1523

  Fly  1372 TGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            .||||||:|||||..||||||||||||||||||:..:||||||.|||||:|||:|
  Rat  1524 NGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1578

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HecwNP_572574.2 PHA03247 <411..562 CDD:223021 36/172 (21%)
WW 638..667 CDD:459800 22/28 (79%)
HECW1_helix 738..794 CDD:465766 24/55 (44%)
HECTc 1068..1424 CDD:238033 278/355 (78%)
Hecw2NP_001101688.1 HECW_N 45..162 CDD:465177
C2_NEDL1-like 185..321 CDD:176073 10/37 (27%)
DMP1 <345..731 CDD:462128 103/544 (19%)
NESP55 <464..632 CDD:115071 42/218 (19%)
WW 815..844 CDD:459800 22/28 (79%)
HECW1_helix 921..987 CDD:465766 26/73 (36%)
WW 993..1022 CDD:459800 15/28 (54%)
HECTc 1222..1576 CDD:238033 278/355 (78%)
Blue background indicates that the domain is not in the aligned region.

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