DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and Itch

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_008760557.1	Gene:	Itch / 311567	RGDID:	1359556	Length:	864	Species:	Rattus norvegicus

Alignment Length:	1030	Identity:	316/1030 - (30%)
Similarity:	442/1030 - (42%)	Gaps:	314/1030 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   432 EEQASPRLLLSPKRPRSPPSGCSTRSASPLDI---SLSPEQHSPTRGR---GVGGALQDAVPPGT 490
            ||......|:..|.|        |.:...|.:   .|..|....|.|.   ..|....||
  Rat   114 EEVVMTLQLVGDKEP--------TETMGDLSVCLDGLQVEAEVVTNGETSCSEGATQNDA----- 165

  Fly   491 PTFHGQRPQQRLLKRVGGG-----AGAGATGGATGSPLVCPPTPTHHARRHARLQAVTANS-SLA 549
                |.||:........|.     |.:|....|.|:                       || ||:
  Rat   166 ----GCRPKDETRVSTNGSEDPEVAASGENKRANGN-----------------------NSPSLS 203

  Fly   550 SGGAIPSDPPAVS----------SQLDYIYLQDGGQEQGQEQSDEVVHISST-RLPSIPERSAAA 603
            :||..||.||..|          :.::       |.......||.    ||| .||  |..:...
  Rat   204 NGGFKPSRPPRPSRPPPPTPRRPASVN-------GSPSTNSDSDG----SSTGSLP--PTNTNVN 255

  Fly   604 AAAAAAAAAGAALMEPGTGTVSGSSG---AGAAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQ 665
            ::|:..||:|  |:.|  .|:||.||   .....:.||||.||.|:|.|||::|:||..:.|:|.
  Rat   256 SSASEGAASG--LIIP--LTISGGSGPRPLNTVSQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWD 316

  Fly   666 RPGAAPSGGPAGREQHHRQQLDRRYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATA 730
            ||...|.|
  Rat   317 RPEPLPPG--------------------------------------------------------- 324

  Fly   731 IHPAILMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQ 795

  Rat   325 ----------------------------------------------------------------- 324

  Fly   796 MSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVVRHRQ-QHSQQQSSVGYYYPDL 859
                    ||.::|..|:.:::||..|.|::..|.|  |..|.....| |.||.|.::..:....
  Rat   325 --------WERRVDNMGRIYYVDHFTRTTTWQRPTL--ESVRNYEQWQLQRSQLQGAMQQFNQRF 379

  Fly   860 VDGN-CLSATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRS 923
            :.|| .|.|||.:....|      :.||||.....:.|:.| .:...||...|.
  Rat   380 IFGNQDLFATSQNKEFDP------LGPLPPGWEKRTDSNGR-VYFVNHNTRITQ----------- 426

  Fly   924 AYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEG 988
                            :||                      ...||      ||.||
  Rat   427 ----------------WED----------------------PRSQG------QLNEK-------- 439

  Fly   989 VPALERLGHDLQLTILLSLFEQEIMGFVPIEERS-----PQ-GSPVLNSRMPQRAPPPFRRDFEA 1047
             |..|  |.:::.|:      ..|..||....|:     |: |...|::. ||.|   :.|||:|
  Rat   440 -PLPE--GWEMRFTV------DGIPYFVDHNRRATTYIDPRTGKSALDNG-PQIA---YVRDFKA 491

  Fly  1048 KLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGG 1112
            |::.|....:....   |..:|:.:.|..|.||:|::|||.:.:||:| ||.|::..||||||||
  Rat   492 KVQYFRFWCQQLAM---PQHIKITVTRKTLFEDSFQQIMSFSPQDLRR-RLWVIFPGEEGLDYGG 552

  Fly  1113 PSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCH-DWFRFSGRVLGLALVHQYLL 1176
            .:||:|||||.|:.||.|.||||:..|.|.:|::|.| :::..| .:|||.||.:.:||.|...:
  Rat   553 VAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPAS-YINPDHLKYFRFIGRFIAMALFHGKFI 616

  Fly  1177 DAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRE 1241
            |..|:.||||.:|..||.|.||||:|.||:.||.|:::|:| ....|.:.|.|.:|:||.:...:
  Rat   617 DTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNI-EECGLEMYFSVDKEILGEIKSHD 680

  Fly  1242 LKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAG 1306
            |||.|.||::.|:||:||:..:.:|||.|||:|||::...||.|::..:.:..|||:|||:::.|
  Rat   681 LKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCG 745

  Fly  1307 TAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGS 1371
            ..|||.|||:.:..||. |....:.||||||.::...||:|:|||||||||..:|..||:.|.||
  Rat   746 MQEIDLNDWQRHAIYRH-YTRTSKQIVWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGS 809

  Fly  1372 TGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            .||::|||||.||.|.|||:||||||||||||.:.|.|.||||.|:|||..||.|
  Rat   810 NGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	15/28 (54%)
		HECTc	1068..1424	CDD:238033	178/356 (50%)
		HECTc	1092..1423	CDD:214523	169/331 (51%)
Itch	XP_008760557.1	C2_E3_ubiquitin_ligase	17..140	CDD:175988	7/33 (21%)
		WW	289..318	CDD:278809	15/28 (54%)
		WW	321..350	CDD:278809	10/158 (6%)
		WW	401..430	CDD:278809	10/78 (13%)
		WW	440..471	CDD:197736	8/38 (21%)
		HECTc	509..862	CDD:238033	178/356 (50%)
		HECTc	533..861	CDD:214523	169/331 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910