DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and Bag3

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_038891.4	Gene:	Bag3 / 29810	MGIID:	1352493	Length:	577	Species:	Mus musculus

Alignment Length:	608	Identity:	126/608 - (20%)
Similarity:	207/608 - (34%)	Gaps:	205/608 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   609 AAAAGAALMEPGTGTVSGSSGAGAAGEPPLPPAWEARMDSH-GRIFYIDHTTRTTSWQRPGAAPS 672
            :||..:.:|:.       :||.||:...||||.||.::|.. |..|::||.:|||:|..|...|.
Mouse     2 SAATQSPMMQM-------ASGNGASDRDPLPPGWEIKIDPQTGWPFFVDHNSRTTTWNDPRVPPE 59

  Fly   673 G---------GPAG--------REQH---------------------HRQ--------------- 684
            |         ||:.        ||.|                     :||
Mouse    60 GPKDTASSANGPSRDGSRLLPIREGHPIYPQLRPGYIPIPVLHEGSENRQPHLFHAYSQPGVQRF 124

  Fly   685 ------QLDRRYQS-IRRTITNESRA-AQLYNLPTSANSNANSTAPAAPP----PATAIHPAILM 737
                  ...:|.|| :|..:|..::. .|...:|.:|     :||.|.||    |..:..||
Mouse   125 RTEAAAATPQRSQSPLRGGMTEAAQTDKQCGQMPATA-----TTAAAQPPTAHGPERSQSPA--- 181

  Fly   738 LCRPDFYSLLHTNEAALAIYNRNAALKHMVMR------------IRRD--PPCF---QRYQYNKD 785
              ..|..|  .::.|:|....|::...|.:.|            |.|.  .|.|   |:..|.
Mouse   182 --ASDCSS--SSSSASLPSSGRSSLGSHQLPRGYIPIPVIHEQNITRPAAQPSFHQAQKTHYP-- 240

  Fly   786 LVALVNTFAQMSRELP----------SCWETKLDQSGKQF---FIDHQHRRTSFMDPRLPVECPR 837
                    ||.....|          ..||.:..::...|   ......|..|......||.||.
Mouse   241 --------AQQGEYQPQQPVYHKIQGDDWEPRPLRAASPFRSPVRGASSREGSPARSGTPVHCPS 297

  Fly   838 VVR------------HR------QQHSQQQSSVGYYYPDLVDGNC-LSATSGHINASPASSVSGV 883
            .:|            ||      |..::.:|..|...|||..|:. :.......::.|.|..|..
Mouse   298 PIRVHTVVDRPQPMTHREPPPVTQPENKPESKPGPAGPDLPPGHIPIQVIRREADSKPVSQKSPP 362

  Fly   884 P-----------PLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATA 937
            |           |:|.|.||.:.|:..|...:             :.|::.|..:...|...|..
Mouse   363 PAEKVEVKVSSAPIPCPSPSPAPSAVPSPPKN-------------VAAEQKAAPSPAPAEPAAPK 414

  Fly   938 AGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQLT 1002
            :|..:.|          .:.|.:|::           ..:.||:..|. :.|.:.|....|.:..
Mouse   415 SGEAETP----------PKHPGVLKV-----------EAILEKVQGLE-QAVDSFEGKKTDKKYL 457

  Fly  1003 ILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHK 1067
            ::.....:|::.   ::...|:|...:...         |||...|:::...|||.|.. ..|.:
Mouse   458 MIEEYLTKELLA---LDSVDPEGRADVRQA---------RRDGVRKVQTILEKLEQKAI-DVPGQ 509

  Fly  1068 LKLH-IRRSHL-LEDAFRRIMSA 1088
            :::: ::.|:| .|...:.||.|
Mouse   510 VQVYELQPSNLEAEQPLQEIMGA 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	14/29 (48%)
		HECTc	1068..1424	CDD:238033	6/23 (26%)
		HECTc	1092..1423	CDD:214523
Bag3	NP_038891.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81		27/85 (32%)
		WW	23..55	CDD:197736	15/31 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..207		22/92 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..427		44/230 (19%)
		BAG	426..503	CDD:214591	17/100 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..577		3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900