DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and Wwp1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_006237992.1	Gene:	Wwp1 / 297930	RGDID:	1311734	Length:	968	Species:	Rattus norvegicus

Alignment Length:	1268	Identity:	325/1268 - (25%)
Similarity:	503/1268 - (39%)	Gaps:	393/1268 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 FNLWVARECFE--TVPAEMVDTLSMAEVDEEVDEEEDEEAAAVESLLGAAAALQ-----ASAHVQ 283
            |..|..:.||.  ::.....:...||......|..::.           :..||     :||.::
  Rat    27 FQFWALQTCFSYYSICHNQGEFWDMATASPRSDTSDNH-----------SGRLQLKVTVSSAKLK 80

  Fly   284 RRQQQQHHQHLRQPSPPQHRPLERSWPPRAVGRDLKLQGDVFQFDILDTDERLAEEMAQGSGSSN 348
            |:                     ::|...|:..::.:.|::             ::.|:.|.|||
  Rat    81 RK---------------------KNWFGTAIYTEVIVDGEI-------------KKTAKSSSSSN 111

  Fly   349 NSPLATPPVRFKPLLKKKIGPDSYINTISTQKVPVHQSYEFPTFPSSSAVGSSSSSPNSLQFPYL 413
                        |...:::     |..::.|.....:.:...|..:.:.:|.::.   .|:...|
  Rat   112 ------------PKWDEQL-----IVNVAPQTTLEFRVWSHHTLKADALLGKATV---DLKQVLL 156

  Fly   414 RQHRPLTRALSNGKASSSEEQASPR----------LLLSPK----RPRSPP-----SGCS----- 454
            ..:|.|.:.....|.|...:....:          |::.|:    |..|||     :|.:
  Rat   157 THNRKLEKVKEQLKLSLENKNGIVQTGELTVVLDGLVIEPEAVTNRSSSPPIEIQQNGDAVHENG 221

  Fly   455 ---TRSASPLDI--SLSPEQHSPTR--------GRGVGGALQDAVPPGTPTFHGQRPQQRLLKRV 506
               ||:...|.:  ::..:.|..|.        ...|.|....:.||...|    |||..
  Rat   222 DPLTRTTPRLAVEGTIGIDNHVSTSTVVPSSCCSHIVNGENTPSSPPQVAT----RPQNT----- 277

  Fly   507 GGGAGAGATGGATGSPLVCPPTPTHHARRHARLQAVTANSSLASGGAIPSDPPAVSSQLDYIYLQ 571
                       ....||...||..   ..:....:|.|:|:.|.|.::||:....:|......:|
  Rat   278 -----------PAPKPLTSEPTSD---TVNGESSSVLADSTSAMGTSLPSEDSTSTSNCTSTTVQ 328

  Fly   572 DGGQEQGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSGSS-------- 628
            :...::....|:.     |..:||         |:|.......:|::|.:.:.:.|.
  Rat   329 EPPVQEPPASSEH-----SECIPS---------ASAEVGPEARSLIDPDSDSRNNSGFDKVRQPE 379

  Fly   629 --------GAGAAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQ 685
                    .:|......||..||.|.|.|||.:|:||.||||:|:||...|.|
  Rat   380 GCVEPLRPQSGNTNTESLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPG------------ 432

  Fly   686 LDRRYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTN 750
            .:||.         :.|....|     .:.|..:|....|...:..:       ...:.|..:..
  Rat   433 WERRV---------DDRGRVYY-----VDHNTRTTTWQRPTMESVRN-------FEQWQSQRNQL 476

  Fly   751 EAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQF 815
            :.|:..:|                   |||.|:..::|..|   .....||..||.::|.:.:.:
  Rat   477 QGAMQQFN-------------------QRYLYSASMLAAEN---DPYGPLPPGWEKRVDSTDRVY 519

  Fly   816 FIDHQHRRTSFMDPR---LPVECPR----VVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHIN 873
            |::|..:.|.:.|||   ||.|.|.    .:|:.::      .|.|:    ||
  Rat   520 FVNHNTKTTQWEDPRTQGLPNEEPLPEGWEIRYTRE------GVRYF----VD------------ 562

  Fly   874 ASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAA 938
                                            ||..||:
  Rat   563 --------------------------------HNTRTTT-------------------------- 569

  Fly   939 GYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQLTI 1003
             ::|                       .|.|:.::::
  Rat   570 -FKD-----------------------PRNGKSSVTK---------------------------- 582

  Fly  1004 LLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKL 1068
                                 |.|.:          .:.|.|..||..|....:|...   |..:
  Rat   583 ---------------------GGPQI----------AYERSFRWKLAHFRYLCQSNAL---PSHV 613

  Fly  1069 KLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLF 1133
            |:::.|..|.||:|::||:....||:| ||.|::..||||||||.:||:|||||.|:.||.|.||
  Rat   614 KINVSRQTLFEDSFQQIMALKPYDLRR-RLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLF 677

  Fly  1134 EYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDL 1198
            ||:..:.|.:|::|.|....:...:|.|.||.:.:||.|...:|..|:.||||.:|...:.:.||
  Rat   678 EYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDL 742

  Fly  1199 ESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERM 1263
            ||:|.||:.||.|||||:| ....|.:.|.|..|:||.|...:||.||.||::.|:||.||:..|
  Rat   743 ESIDTEFYNSLIWIRDNNI-EECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLM 806

  Fly  1264 IKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDN 1328
            .:||..|||||||::.:.||.||:..:.:..||.:|||:::.|..|:|..||:.||.||. |..|
  Rat   807 TEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRN 870

  Fly  1329 HQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNALPRAHT 1393
            .:.|:||||.::...||.|:|||||||||..:|..||:.|.||.||::|||||.||...|||:||
  Rat   871 SKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHT 935

  Fly  1394 CFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            ||||||||||.:.|.|.||||.|:|||..||.|
  Rat   936 CFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	17/28 (61%)
		HECTc	1068..1424	CDD:238033	175/355 (49%)
		HECTc	1092..1423	CDD:214523	167/330 (51%)
Wwp1	XP_006237992.1	C2_E3_ubiquitin_ligase	67..190	CDD:175988	24/176 (14%)
		PARM	243..>400	CDD:293666	34/193 (18%)
		WW	397..426	CDD:278809	17/28 (61%)
		WW	429..458	CDD:278809	8/54 (15%)
		WW	504..533	CDD:278809	8/28 (29%)
		WW	545..574	CDD:238122	10/132 (8%)
		HECTc	614..966	CDD:238033	175/354 (49%)
		HECTc	637..965	CDD:214523	167/330 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810