Protein Alignment Hecw and Bag3

DIOPT Version :10

• Sequence 1: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_001011936.1
• Gene: Bag3 / 293524
• RGDID: 1307794
• Length: 574
• Species: Rattus norvegicus
• Alignment Length: 643
• Identity: 130/643 - (20%)
• Similarity: 203/643 - (31%)
• Gaps: 243/643 - (37%)

  Fly   614 AALMEPGTGTVSGSSGAGAAGEPPLPPAWEARMDSH-GRIFYIDHTTRTTSWQRPGAAPSG---- 673
            ||...|   .:..:||.||:...||||.||.::|.. |..|::||.:|||:|..|...|.|
  Rat     3 AATQSP---VMQMASGNGASDRDPLPPGWEIKIDPQTGWPFFVDHNSRTTTWNDPRVPPEGPKET 64

  Fly   674 -----GPA--------GREQH---------------HRQQLDRR---------YQSIRRTITNES 701
                 ||:        .||.|               |.:..:.|         ...::|..|..:
  Rat    65 ASSANGPSRDGSRLLPAREGHPIYPQLRPGYIPIPVHHEGSENRQPHLFHAYSQPGVQRFRTEAA 129

  Fly   702 RAA--------------------QLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSL 746
            .||                    |...:|.:|.:.    .|.|..|..:..||     ..|..|
  Rat   130 AAAPQRSQSPLRGGVTETTQTDKQCGQVPAAATAQ----PPTAHGPERSQSPA-----ASDCSS- 184

  Fly   747 LHTNEAALAIYNRNAALKHMVMR------------IRRD--PPCF---QRYQYNKDLVALVNTFA 794
             .::.|:|....|::...|.:.|            |.|.  .|.|   |:..|.          |
  Rat   185 -SSSSASLPSSGRSSLGSHQLPRGYIPIPVIHEQNITRPAAQPSFHQAQKTHYP----------A 238

  Fly   795 QMSRELP----------SCWETKLDQSGKQFFIDHQHRRTS-FMDP--------------RLPVE 834
            |.....|          ..||.:            ..|.|| |..|              ..||.
  Rat   239 QQGEYQPQQPVYHKIQGDDWEPR------------PLRATSPFRSPVRGASSREGSPARSGTPVH 291

  Fly   835 CPRVVR------------HR------QQHSQQQSSVGYYYPDLVDGNC-LSATSGHINASPAS-- 878
            ||..:|            ||      |..::.:|..|...|||..|:. :.......::.|.|
  Rat   292 CPSPIRVHTVVDRPQPMTHREPPPVTQPENKPESKPGLAGPDLPPGHIPIQVIRREADSKPVSQK 356

  Fly   879 ----------SVSGVP---PLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGM 930
                      .||..|   |.|.|.||:..||.::                 :.|:..|..:...
  Rat   357 PPPPAEKVEVKVSSAPIPCPSPGPAPSAVPSSPKN-----------------VAAEPKAAPSPAP 404

  Fly   931 ASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERL 995
            |.|.:..:|..:.|          .:.|.:|::           ..:.||:..|. :.|...|..
  Rat   405 AEAASLKSGDAEAP----------HKHPGVLKV-----------EAILEKVQGLE-QAVDNFEGK 447

  Fly   996 GHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKG 1060
            ..|.:..::.....:|::.   ::...|:|...:...         |||...|:::...|||.|.
  Rat   448 KTDKKYLMIEEYLTKELLA---LDSVDPEGRADVRQA---------RRDGVRKVQTILEKLEQKA 500

  Fly  1061 YGQGPHKLKLH-IRRSHL-LEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSRE 1116
            . ..|.::::: ::.|:| .|...:.||.|...|               .|..||..|
  Rat   501 I-DVPGQVQVYELQPSNLEPEQPLQEIMGAVAAD---------------KDKKGPENE 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021
		WW	638..667	CDD:459800	14/29 (48%)
		HECW1_helix	738..794	CDD:465766	13/72 (18%)
		HECTc	1068..1424	CDD:238033	11/51 (22%)
Bag3	NP_001011936.1	WW	23..55	CDD:197736	15/31 (48%)
		PRK12323	<260..>372	CDD:481241	23/123 (19%)
		BAG	423..500	CDD:214591	17/100 (17%)