Protein Alignment CG42797 and Wwp2

DIOPT Version :9

• Sequence 1: NP_572574.2
• Gene: CG42797 / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_001099654.1
• Gene: Wwp2 / 291999
• RGDID: 1310091
• Length: 870
• Species: Rattus norvegicus
• Alignment Length: 1195
• Identity: 327/1195 - (27%)
• Similarity: 460/1195 - (38%)
• Gaps: 357/1195 - (29%)

  Fly   263 AAAVESLLGAAAALQASAHVQRRQQQQHHQHLRQPSPPQH-------RPLERSWPPRAVGRDLKL 320
            |:|..|..|.|...:.|....|....:...|.|||....:       .|.|.....:.:|....|
  Rat     2 ASASSSRAGVALPFEKSQLTLRVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELL 66

  Fly   321 QGDVFQFDILDTDERLAEEMAQGSGSSNNSPLATPPVRFKPLLKKKIG----PDSYINTISTQKV 381
            ..:|...::  |.:...:.......:..|..|.|..|....:||...|    ....:|..:..|.
  Rat    67 WNEVIVLNV--TAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENTQLTLNLQTENKG 129

  Fly   382 PVHQSYEFPTFPSSSAVGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQASPRLLLSPKRP 446
            .|....|...|.....|...|                    :.||.|.:...|
  Rat   130 SVVSGGELTIFLDGPTVDLGS--------------------VPNGSAVTDGSQ------------ 162

  Fly   447 RSPPSGCSTRSASPLDISLSPEQHSPTRGRGVGGALQDAVPPGTPTFHGQRPQQRLLKRVGGGAG 511
              |||..|:.:|      |:||    ||.:          ||.|..|.|   :.|..:..||.|
  Rat   163 --PPSRESSGTA------LAPE----TRHQ----------PPSTNCFGG---RSRTHRHSGGSA- 201

  Fly   512 AGATGGATG--SPLVCPPTPTHHARRHARLQAVTANSSLASGGAIPSDPPAVSSQLDYIYLQDGG 574
              .|..|||  ||         .||...|......:||..:.|.:..:|...|
  Rat   202 --RTATATGEQSP---------GARNRHRQPVKNPSSSGLANGTVSEEPTTAS------------ 243

  Fly   575 QEQGQEQSDEVVHISSTRLPSI-----PERSAAAAAAAAAAAAGAALMEPGTGTVSGSSGAGAAG 634
                  ..:|:..:..|..|:.     |..:..:..|.:..|.|.   ||.|   ||:....||.
  Rat   244 ------DPEELSVVGVTSPPAAASSVSPNPNTTSLPAPSTPAEGE---EPST---SGTQQLPAAA 296

  Fly   635 EPP--LPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRYQSIRRTI 697
            :.|  ||..||.|...:||::|:||.|:||:|:||
  Rat   297 QAPDALPAGWEQRQLPNGRVYYVDHNTKTTTWERP------------------------------ 331

  Fly   698 TNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAA 762
                                                                             
  Rat   332 ----------------------------------------------------------------- 331

  Fly   763 LKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFM 827
                                                 ||..||.:.|..|:.:::||..|.|::.
  Rat   332 -------------------------------------LPPGWEKRTDPRGRFYYVDHNTRTTTWQ 359

  Fly   828 DPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHIN-----ASPASSVSGVP--P 885
            .|     ....||:.:|...|:             |.|.....|.:     .|.::|....|  |
  Rat   360 RP-----TAEYVRNYEQWQSQR-------------NQLQGAMQHFSQRFLYQSSSASTDHDPLGP 406

  Fly   886 LPPPRPSSSSSSSRSSHGH----GHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIA 946
            |||      ....|..:|.    .||..||.     ....|:    .||....|...|:|   :.
  Rat   407 LPP------GWEKRQDNGRVYYVNHNTRTTQ-----WEDPRT----QGMIQEPALPPGWE---MK 453

  Fly   947 YNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQE 1011
            |..:.:.:.                                       :.|:.:.|    .|:..
  Rat   454 YTSEGVRYF---------------------------------------VDHNTRTT----TFKDP 475

  Fly  1012 IMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSH 1076
            ..||   |..:.|||           |..:.|.|..|...|.....|...   |..:|:.:.|..
  Rat   476 RPGF---ESGTKQGS-----------PGAYERSFRWKYHQFRFLCHSNAL---PSHVKISVSRQT 523

  Fly  1077 LLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTY 1141
            |.||:|::||:....||:| ||.::...||||||||.:||:|||||.|:.||.|.||||:..:.|
  Rat   524 LFEDSFQQIMNMKPYDLRR-RLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNY 587

  Fly  1142 TVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFH 1206
            .:|::|.|:...:...:|||.||.:.:||.|...:|..||.||||.:|.....|.||||:|.||:
  Rat   588 CLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLRDLESIDPEFY 652

  Fly  1207 QSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERG 1271
            .|:.||::|::.. ..|.|.|....|:||.|...|||.||:||.:.|:||:||:..:..||..||
  Rat   653 NSIIWIKENNLDE-CGLELFFIQDMEILGKVTTHELKEGGENIRVTEENKEEYIMLLTDWRFTRG 716

  Fly  1272 VQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFW 1336
            |:|||::.:.||.||.....:..||.:||||::.|..|||.:||:.|..||. |..:.:.|.|||
  Rat   717 VEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNAIYRH-YTKSSKQIQWFW 780

  Fly  1337 QVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNALPRAHTCFNRLDLP 1401
            ||::...||:|:|||||||||..:|..||:.|.||.||::|||::.||...|||:||||||||||
  Rat   781 QVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDRVGKETWLPRSHTCFNRLDLP 845

  Fly  1402 PYPTPELLYEKLLLAVEETNTFGIE 1426
            ||.:.|.|.||||.|:|||..||.|
  Rat   846 PYKSYEQLKEKLLYAIEETEGFGQE 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	14/28 (50%)
		HECTc	1068..1424	CDD:238033	171/355 (48%)
		HECTc	1092..1423	CDD:214523	163/330 (49%)
Wwp2	NP_001099654.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988	24/126 (19%)
		WW	302..331	CDD:278809	14/28 (50%)
		WW	332..361	CDD:278809	10/28 (36%)
		WW	407..435	CDD:278809	9/38 (24%)
		WW	447..477	CDD:238122	6/75 (8%)
		HECTc	516..868	CDD:238033	171/354 (48%)
		HECTc	539..867	CDD:214523	163/330 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810