DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and Nedd4l

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_038952600.1	Gene:	Nedd4l / 291553	RGDID:	735047	Length:	1259	Species:	Rattus norvegicus

Alignment Length:	1440	Identity:	395/1440 - (27%)
Similarity:	592/1440 - (41%)	Gaps:	399/1440 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 SPTNSYNGSIGSDGGSSVGGGA-RRKSWTLSPQSGGSTPLSGA-KKKTKTGAPTTTLSNANGDGF 226
            |..:.:..:.|.|.|...|.|| :|.|....||.     |:|. .:.|::.:...:|.....||
  Rat    42 SSPHPFTQNAGEDSGLQEGVGALKRSSSMFIPQL-----LAGVDARPTRSSSMKISLQRKAADG- 100

  Fly   227 NLWVARECFETVPAEMVDTLSMAEVDEEVDEEEDEEAAAVESLLGAAAALQASAHVQRRQQQQHH 291
               ....|   .|.|..|               |...:|...|...|||.:.||.:..
  Rat   101 ---ATDSC---GPQEGPD---------------DRPPSAQGDLGDQAAATRVSAQIGS------- 137

  Fly   292 QHLRQPSP---PQHRPLERSWPPRAVGRDLKLQGDVFQFDILDTDERLAEEMAQGSGSSNNSPLA 353
               .:|||   |...|...:|.|..:     :.|..   |......||||:..:          |
  Rat   138 ---SEPSPVDTPGSSPPRAAWDPGTL-----VNGTC---DHRGPSPRLAEDTEE----------A 181

  Fly   354 TPPVRF---------KPLLKKKIGPDSYI--NTISTQKVP-----------VHQSYEFPTFPSSS 396
            ||.:|.         :.:.....|||...  ...|.|.||           |.|..:    |...
  Rat   182 TPGLRIQHRASSADVRQVRLLPFGPDGQAEPRRWSLQHVPDASGSSGKRCFVFQLQQ----PHQG 242

  Fly   397 AVG---------SSSSSPNSLQFPYLRQHRPLT-----RALSNGKASSSEE----QASPRLLL-- 441
            .||         :.:.....:::|.:|..|..:     ||   |:.|.:|:    :||||.::
  Rat   243 TVGLGSDFNFGFTGTKGDRLVRYPRIRLERSTSYPTQPRA---GRVSPTEDRGTPEASPRRMVPE 304

  Fly   442 -----SPKRPRSPPSGCSTRSASPLDISLSPEQH---SPTRGRGVGGALQDAVP--PGTPTFHGQ 496
                 |.:.|:||  ||..:.....:   :.:||   ..|||.......|:..|  ||.|
  Rat   305 IRRTNSERTPQSP--GCMFKIRQDQN---AGQQHFRILVTRGPEEAPQNQEETPKSPGHP----- 359

  Fly   497 RPQQRLLKRVGGGAGAGATGGATGSPLVCPPTPTHHARRHARLQAVTANSSLASGGAIPSDPPAV 561
                        |.|........|...|    |..|                     :|::.|.:
  Rat   360 ------------GTGVPTRDDFLGQVDV----PLSH---------------------LPTEDPTM 387

  Fly   562 SS----------------------QLDYIYL-QDGGQ-EQGQEQSDEVVHISSTRLPSIPERSAA 602
            ..                      :|...|: ::||| |:..||.|:
  Rat   388 ERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSEQRDD------------------ 434

  Fly   603 AAAAAAAAAAGAALMEPGTGTVSGSSGAGAAGE----PPLPPAWEARMDSHGRIFYIDHTTRTTS 663
                          ||.|...|..:..|....|    |||||.||.::|:.||.:|::|..|:|.
  Rat   435 --------------MEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRSTQ 485

  Fly   664 WQRPGA--APSGGPAGREQHHRQQLDRRYQSIRRTITN--ESRAAQ--------LYNLPTSANSN 716
            |.||..  ..|.......|.:::...||::| ||.|:.  |..|::        ...:....|..
  Rat   486 WHRPSLMDVSSESDNNIRQINQEAAHRRFRS-RRHISEDLEPEASEGGGEGPEPWETISEEVNMA 549

  Fly   717 ANSTAPAAPP----PATAIHPAIL-------MLCRPDF----YSLLHTNEAALAIYNRNAALKHM 766
            .:|.:.|.||    |.:...|..|       :...||.    :|.|...|.:..:  |:.::...
  Rat   550 GDSLSLALPPPPASPVSRTSPQELSEELSRRLQITPDSNGEQFSALIQREPSSRL--RSCSVTDT 612

  Fly   767 VMRIRRDPP-----------CFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQ 820
            |......||           .....:.:...||.|:|    :..|||.||.:.|..|:.::::|.
  Rat   613 VAEQAHLPPPSTPTRRARSSTVTGGEESTPSVAYVHT----TPGLPSGWEERKDAKGRTYYVNHN 673

  Fly   821 HRRTSFMDPRLP-----------------VECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSAT 868
            :|.|::..|.:.                 || |::   |:..|....:|....|  ::|    |.
  Rat   674 NRTTTWTRPIMQLAEDGASGSATNSNNHLVE-PQI---RRPRSLSSPTVTLSAP--LEG----AK 728

  Fly   869 SGHINASPASSVSGVPPLPPPRPSSSSSSSR---------------SSHGH----GHNCNTTSAI 914
            ...|..:...::|. |..|.|.|.:|.....               :.:|.    .||..||:
  Rat   729 DSPIRRAVKDTLSN-PQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTT-- 790

  Fly   915 SCALNADRSAYGAAGMASAGATAAGYED----VPIAYNEKVIAFLRQPNILEILRERQGQHTMSR 975
                                     :||    .|:....|...   .||.|..|
  Rat   791 -------------------------WEDPRLKFPVHMRSKASL---NPNDLGPL----------- 816

  Fly   976 QLREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPP- 1039
                         .|..|...|....|..:....|.:.|    |..:.:..|:.:|::.|...|
  Rat   817 -------------PPGWEERIHLDGRTFYIDHSSQVLCG----ENDTRESVPLYDSKITQWEDPR 864

  Fly  1040 -----------PFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDL 1093
                       |:.|:|:.|...|.:||  |.....|::.::.:.|:::.|:::|||||..:.|:
  Rat   865 LQNPAITGPAVPYSREFKQKYDYFRKKL--KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDV 927

  Fly  1094 QRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCH-D 1157
            .:.||.:.:::|:||||||.:||:|||||:|:||||||||||||.|.||:|::|.|...:..| .
  Rat   928 LKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLS 992

  Fly  1158 WFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVD 1222
            :|.|.|||.|||:.|..|||.||.|||||.:|...:.|:|:||:|:|::.||:||.:||   ..:
  Rat   993 YFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEND---PTE 1054

  Fly  1223 LGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVI 1287
            |.|.||:.||..|.....:|||.|..|::..:||:||::.:|:||....||:|..:.:.||.|::
  Rat  1055 LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELL 1119

  Fly  1288 DSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQ 1352
            ...|:.:||..||||::.|..::|.||||.::.|::||..||.||.|||:.:.....|:|:||||
  Rat  1120 PIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQ 1184

  Fly  1353 FVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAV 1417
            ||||||.:|..||:.|.||.||:.|.||:||.|..||||||||||||||||.|.|.|.||||:||
  Rat  1185 FVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 1249

  Fly  1418 EETNTF-GIE 1426
            |....| |::
  Rat  1250 ENAQGFEGVD 1259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	13/28 (46%)
		HECTc	1068..1424	CDD:238033	177/357 (50%)
		HECTc	1092..1423	CDD:214523	169/331 (51%)
Nedd4l	XP_038952600.1	C2	<365..418	CDD:417471	7/77 (9%)
		WW	463..489	CDD:395320	10/25 (40%)
		WW	653..682	CDD:395320	10/28 (36%)
		WW	766..796	CDD:238122	7/56 (13%)
		WW	815..865	CDD:197736	12/77 (16%)
		HECTc	926..1255	CDD:214523	169/331 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810