DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42797 and Hecw1

DIOPT Version :9

Sequence 1:NP_572574.2 Gene:CG42797 / 31905 FlyBaseID:FBgn0261931 Length:1426 Species:Drosophila melanogaster
Sequence 2:XP_017455974.1 Gene:Hecw1 / 291209 RGDID:1561038 Length:1603 Species:Rattus norvegicus


Alignment Length:1502 Identity:577/1502 - (38%)
Similarity:757/1502 - (50%) Gaps:300/1502 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 GNESDELEQAFQ-SALTLTNDV-HVSVSEVEEHEPPLASRNQEVAEVEEQQQQLGACALPQPSEA 131
            ||..:.:.||.. |.::|..|| .:.|.:......|:..|            .||..::|.    
  Rat   258 GNTVNPIWQAEHFSFVSLPTDVLEIEVKDKFAKSRPIIKR------------FLGKLSMPV---- 306

  Fly   132 SLTGSKETREPRHHQTLLSTKSCETPANNATLS---PTNSYNGSI--GSDGGSSVGGGARRKSWT 191
                          |.||...:......:.||.   ||:..:|.:  ..:..||:.......|..
  Rat   307 --------------QRLLERHAIGDRVVSYTLGRRLPTDHVSGHLQFRFEITSSIHADDEEISLN 357

  Fly   192 LSPQSGGSTPLSGAKKKTKTGAPTTTLSNANGDGFNLWVARECFETVPAEMVDTLSMAEVDEEVD 256
            ..|:|.          :.:.....:.:.|::|:             .|.:..:.|.  ::..|..
  Rat   358 AEPESA----------EVQDSVMNSVVENSSGE-------------PPGDAAEFLK--DLKPEAP 397

  Fly   257 EEED----------EEAAAVESLLGAAAALQASAHVQRRQQ----QQHHQHLRQPS-----PPQH 302
            .|||          |.|..||...||......|...:..::    |...||..||:     ..:.
  Rat   398 SEEDGVRGSENENREHARPVEEAAGAMETRDDSKFSEGPEEVGELQDPEQHDTQPTLSAEEVAER 462

  Fly   303 RPLERSWPPRAVGRDLKLQGDVFQFDILDTDERLAEEMAQ-GSGSSNNSPLAT-----PPVRFKP 361
            .||....||..:..:....|...:.:.:..:....|||.: |........::.     |.:..:.
  Rat   463 LPLGEGCPPSLLPEESTALGSKAEEEAIPENGAGEEEMQEKGKDEEEEEGVSALEQGEPGLELRA 527

  Fly   362 LLKKKIGPDSYINTISTQKVPVHQSYEFPTFPSSSAVGSSSSSPNSLQFPYLRQHRPLTRALSNG 426
            .::||..|.|                 .|.....:.:.|:.....:.:..|:|.|..|....|..
  Rat   528 SVRKKSRPCS-----------------LPVSELETVIASACGEAETPRTHYIRIHTLLHSMPSAQ 575

  Fly   427 KASSSEEQ--ASPRLLLSPKRPRSPPSGCSTRSASPLDISLSPEQ--------------HSPTRG 475
            :.|::||:  ......|.....:...|...|.:|.|..:......              |.....
  Rat   576 RGSTTEEEDAMEEESTLKESSEKDGLSEVDTIAADPQSMEDGENNGATLCMASSDCSGGHFSNLS 640

  Fly   476 RGVGGALQDAVPPGTPTFHGQRPQQRLLKRVGGGAGAGATG--GATGSPLVCPPTPTHHARRHA- 537
            :.:|........|.|.:.....|||        ||.....|  .:..|| .|..|..:.:..:: 
  Rat   641 KSIGAGQDGEAHPSTGSESDSSPQQ--------GADHSCEGCDASCCSP-SCYSTSCYSSSCYSS 696

  Fly   538 ------------RLQAVTANSSLASGGAIPSDPPAVSSQLDYIYLQDGGQEQGQEQSDEVVHISS 590
                        |..:.|..||:.|  |..|:....|||.|         |:.:..:.|.|. .|
  Rat   697 SCYSSSCYNGNNRFASHTRFSSVDS--AKISESTVFSSQED---------EEEENSAFESVP-DS 749

  Fly   591 TRLPSI---------PERSAAAAAAAAAAAAGAALMEPGTGTVSGSSGAGAA---GEP------- 636
            .:.|.:         |.:...||....||.....|..|..|..:...|....   .:|       
  Rat   750 VQSPELDPESTNGAGPWQDELAAPGGNAARTTEGLDSPMAGPSNRREGDCPMLHNSQPISQLPSL 814

  Fly   637 ------------PLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGR----EQHHRQQ 685
                        ||||.||||:|||||:||:||..|||:||||..||:  |.|.    ..|..:|
  Rat   815 RPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPSMAPT--PDGMIRSGSVHQMEQ 877

  Fly   686 LDRRYQSIRRTITNESRAAQLYN-----LP-------------TSANSNAN-----STAPAAPPP 727
            |:||||:|:|||..|.......|     :|             .|:.||.:     |.:|.....
  Rat   878 LNRRYQNIQRTIATERSEEDSGNQSCEQIPDGGAGGGGSDSEAESSQSNLDLRREGSLSPVNSQK 942

  Fly   728 ATAI--HPAILMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALV 790
            .|.:  .||:..:..|:|:::||.|.:|..::..:..||||::::|||...|:|||:|:|||..:
  Rat   943 VTLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFI 1007

  Fly   791 NTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVVRH--RQQHSQQQSSVG 853
            |.||....|||..||.|.|..||.||:||..|.|:|:|||:|::..|:..|  .:||.|:..|  
  Rat  1008 NMFADTRLELPRGWEIKTDHQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRS-- 1070

  Fly   854 YYYPDLVDGNCLSATSGHINASPASSVS---GVPPLPPPRPSSS-SSSSRSSHGHGHNCNTTSAI 914
                              .:|..||.||   |...|  .||..| .::.||.|.|          
  Rat  1071 ------------------YSAGEASEVSRNRGASLL--ARPGHSLIAAIRSQHQH---------- 1105

  Fly   915 SCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLRE 979
                                      |.:|:|||:|::||||||||.|:|:|||.....:..|||
  Rat  1106 --------------------------ESLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLRE 1144

  Fly   980 KINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEE---------------RSPQGSPVL 1029
            ||:.:|.||...||:|..|..|.|||||||:|||.:||::.               .|||.||.|
  Rat  1145 KIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQSAFHPGYSFSPRCSPCSSPQNSPGL 1209

  Fly  1030 NSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQ 1094
             .|...|||.|:|||||||||:||||||:||:||||.|:||.|||.||||..|.::|:.::|:||
  Rat  1210 -QRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQ 1273

  Fly  1095 RGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWF 1159
            |.:|.:.:..||||||.|||||||||||:|||||||||||||||||||||:||:||||:|..:||
  Rat  1274 RNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENYLEWF 1338

  Fly  1160 RFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLG 1224
            |||||:|||||:|||||||||||||||.||:||..|||||.||.||||||||::||:| |.: |.
  Rat  1339 RFSGRILGLALIHQYLLDAFFTRPFYKGLLKLPCDLSDLEYLDEEFHQSLQWMKDNNI-TDI-LD 1401

  Fly  1225 LTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDS 1289
            |||.|.||:.|.|.:||||.||.|..:.|||||||:|||:|||:||||.:|||:||||||||:||
  Rat  1402 LTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDS 1466

  Fly  1290 RLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFV 1354
            ||||||||||||||||||||||.||||.|||||.||||.|.||.|||..:|||:|||||||||||
  Rat  1467 RLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFV 1531

  Fly  1355 TGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEE 1419
            |||||:|||||:|||||.|.||||||||||..:|||||||||||||||||:...||||||.||||
  Rat  1532 TGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSTLYEKLLTAVEE 1596

  Fly  1420 TNTFGIE 1426
            |:|||:|
  Rat  1597 TSTFGLE 1603

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42797NP_572574.2 WW 638..667 CDD:278809 21/28 (75%)
HECTc 1068..1424 CDD:238033 267/355 (75%)
HECTc 1092..1423 CDD:214523 254/330 (77%)
Hecw1XP_017455974.1 HECW_N 66..185 CDD:293170
C2_NEDL1-like 206..342 CDD:176073 22/113 (19%)
WW 827..857 CDD:197736 22/29 (76%)
WW 1017..1048 CDD:197736 17/30 (57%)
HECTc 1247..1601 CDD:238033 267/355 (75%)
HECTc 1271..1600 CDD:214523 254/330 (77%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 514 1.000 Domainoid score I304
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 897 1.000 Inparanoid score I366
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 1 1.000 - - otm44561
orthoMCL 1 0.900 - - OOG6_105324
Panther 1 1.100 - - O PTHR11254
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1661
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1110.860

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