DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and HERC4

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_011537894.1	Gene:	HERC4 / 26091	HGNCID:	24521	Length:	1081	Species:	Homo sapiens

Alignment Length:	367	Identity:	112/367 - (30%)
Similarity:	184/367 - (50%)	Gaps:	28/367 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly  1068 LKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGL 1132
            |.|.:||.:::.||...:......|.:: .|.|::..|:.:|.||..:|||.|:.|||.:|.||:
Human   733 LILVVRRENIVGDAMEVLRKTKNIDYKK-PLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGM 796

  Fly  1133 FEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSD 1197
            |.| ..|:..:..|. ..|.|:  |.|...|.:.|||:.:..::|..|....||.||:...:|.|
Human   797 FRY-YEDSRLIWFSD-KTFEDS--DLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDD 857

  Fly  1198 LESLDNEFHQSLQWIRD--NDIGTGVDLGLTFC----VTEELLGSVVDRELKPGGKNIIINEKNK 1256
            |:.|..:..:|:|.:.|  .|     |:..|||    :|.|..|:...:||...|.:..:|::|:
Human   858 LKELMPDVGRSMQQLLDYPED-----DIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNR 917

  Fly  1257 KEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEY 1321
            :|:::..:.:...:.|....::...||::|...:::.:|...||:.::.|....|..:...||||
Human   918 QEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEY 982

  Fly  1322 RSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALR---GSTGPRRFCIEKWG 1383
            :..|...|..|..||:|......|::.:.|.|:||:..||..|..:|:   .|||         |
Human   983 KGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTG---------G 1038

  Fly  1384 KPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGI 1425
            ....||.:|||||.||||.|...|.|..||:.|::....|.:
Human  1039 GEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809
		HECTc	1068..1424	CDD:238033	111/364 (30%)
		HECTc	1092..1423	CDD:214523	105/339 (31%)
HERC4	XP_011537894.1	RCC1	2..368	CDD:332518
HERC4	XP_011537894.1	HECTc	733..1079	CDD:238033	111/364 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810