DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and MAGI3

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001136254.1	Gene:	MAGI3 / 260425	HGNCID:	29647	Length:	1481	Species:	Homo sapiens

Alignment Length:	1401	Identity:	245/1401 - (17%)
Similarity:	388/1401 - (27%)	Gaps:	585/1401 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EPPAAPVPLQPLAASSACLADRSPVDPIAV-----------RLQQEEQAEGDDEEEEEEEEDDDD 55
            :|||.|.|.||           .|||.:..           |.....:.|..|....|||||:|.
Human   192 KPPAEPSPFQP-----------DPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEEEDEDK 245

  Fly    56 DP--------------------------KEEEAFYEARNGNESDE----LEQAFQSALTLTNDVH 90
            :.                          .:..:..:.||....||    |.:.::.|.|.|..::
Human   246 EAINGSGNAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNWEMAYTDTGMIY 310

  Fly    91 V--------------------SVSEVEEHEPP------------------LASRNQEVAEVEE-- 115
            .                    :..:.|:.|.|                  |..:.|....|||
Human   311 FIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAK 375

  Fly   116 QQQQLGACALPQPSEASLTGSKETREPRHHQTLLSTKSCETPANNATLSPTNSYNGSIGSDGGSS 180
            :::|||...:.. |:..:..|..||:|...:.:|...|.:.                      |:
Human   376 RKKQLGQVEIGS-SKPDMEKSHFTRDPSQLKGVLVRASLKK----------------------ST 417

  Fly   181 VGGGARRKSWTLSPQSGGSTP--LSGAKKKTKTG--------APTTTLSNANGD---GFNLWVAR 232
            :|.|     :|:   .||..|  ....|...|.|        ||...:.:.||:   |.......
Human   418 MGFG-----FTI---IGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVV 474

  Fly   233 ECFETVPAEMVDTLSMAEVDEEVDEEED---EEAAAVESLLGAAAA----------LQASAHVQR 284
            :.|:.||......|::.......|:.||   :..||...:.|.:..          .:..|.|..
Human   475 QMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLE 539

  Fly   285 RQQQQHH----QHLRQPSPPQHRPLER----SWPPRAVGRDLKLQGDVFQFDILDT--------- 332
            :..:..|    ..|..||....:.:..    |..|..|...|......|.|.|.|:
Human   540 QNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMI 604

  Fly   333 -DERLAEEMAQG--------SGSSNNSPLATPPV--RFK-----PLLKKKIGPDSYINT--ISTQ 379
             |.:..:.:.:|        ....|.:.|....|  :|.     |||..:.||.|...|  :.|.
Human   605 LDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTD 669

  Fly   380 K-----------VPVHQSYEFPTFPSSSAVGSSSSSPNSLQFP-----------------YLRQH 416
            |           .|:.|...||  ||....||....|:.:...                 :||:.
Human   670 KKENAGSLEAINEPIPQPMPFP--PSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQ 732

  Fly   417 R-----------------------PLTRALSNGKASSSEE------------------------- 433
            .                       ||..|..:|:..:::|
Human   733 ESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAA 797

  Fly   434 -------QASPRLLLSPKRPRSPPSGC--STRSASP----LDISLSPEQHSP-------TRGRGV 478
                   ....::....|:|....|..  ||::.||    .::...|....|       ....|.
Human   798 RNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGF 862

  Fly   479 GGAL---QDAVPPGT-PTFHGQ----RPQQRLLK-RVGGGAGA--GAT---------------GG 517
            |..:   ::..|||. |...|:    .|..|..| :||....|  |.:               .|
Human   863 GFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAG 927

  Fly   518 ATGSPLVC-------PPTPTHHARRHARLQAVTANSSLASGGAIPSDPPAVSSQL---------- 565
            .|.:..|.       ||:.|:.||:...||......|.|:  .||.|..|:..::
Human   928 VTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQAN--HIPGDRSALEGEIGKDVSTSYRH 990

  Fly   566 ---DYIYLQD------------------------------------GGQ------------EQGQ 579
               |:.:|..                                    ||:            |.|.
Human   991 SWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGP 1055

  Fly   580 EQSDEVVHISS--TRLPSIPERSAAAAAAAAAAAAGA----ALMEPGTGTV----------SGSS 628
            ...|..:|:..  ..:...|.:......|.....||.    .|:.||||.:          ..||
Human  1056 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDINNPSSS 1120

  Fly   629 GAGAAGEPPLPPAWEARMDSH-GRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRYQS 692
            ......:.||||:      || ..||                         |:.|...::   :|
Human  1121 NVIYDEQSPLPPS------SHFASIF-------------------------EESHVPVIE---ES 1151

  Fly   693 IRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIY 757
            :|..|.  .:|.:|.::.....|..|...|..                 ...|||..|.:
Human  1152 LRVQIC--EKAEELKDIVPEKKSTLNENQPEI-----------------KHQSLLQKNVS----- 1192

  Fly   758 NRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHR 822
                         :||||....:...|:|:.:.|...                           |
Human  1193 -------------KRDPPSSHGHSNKKNLLKVENGVT---------------------------R 1217

  Fly   823 RTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGVPPL- 886
            |...:.|:.|.         .|||::                      |::..|:       ||
Human  1218 RGRSVSPKKPA---------SQHSEE----------------------HLDKIPS-------PLK 1244

  Fly   887 --PPPRPSSSSSSSRSSHGHGHNCNTTSAI-----SCALNADRSA--------YGAAGMAS---- 932
              |..||...|.|  .|.|...:|..::..     .|..:..|||        .|:...::
Human  1245 NNPKRRPRDQSLS--PSKGENKSCQVSTRAGSGQDQCRKSRGRSASPKKQQKIEGSKAPSNAEAK 1307

  Fly   933 ---------AGATAAGYEDVPIAYNEK--VIAFLRQPNILEILRERQGQHTMSRQLREKI----- 981
                     ||.|.:..|.:|.. .||  ||....:.|.||..|.|..:..:.|.:.:.:
Human  1308 LLEGKSRRIAGYTGSNAEQIPDG-KEKSDVIRKDAKQNQLEKSRTRSPEKKIKRMVEKSLPSKMT 1371

  Fly   982 ---------------NILRVEGVPALERLGHDLQLT 1002
                           .:...|...:.:::|.::||:
Human  1372 NKTTSKEVSENEKGKKVTTGETSSSNDKIGENVQLS 1407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	7/29 (24%)
		HECTc	1068..1424	CDD:238033
		HECTc	1092..1423	CDD:214523
MAGI3	NP_001136254.1	Interaction with ADRB1 and TGFA. /evidence=ECO:0000250	18..106
		PDZ_signaling	24..101	CDD:238492
		NK	123..>197	CDD:327404	3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..273		19/91 (21%)
		WW	294..326	CDD:197736	4/31 (13%)
		WW	342..372	CDD:238122	3/29 (10%)
		Interaction with PTEN. /evidence=ECO:0000269\|PubMed:10748157	410..492		20/111 (18%)
		PDZ	413..493	CDD:214570	19/109 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..570		4/27 (15%)
		PDZ	575..656	CDD:214570	15/80 (19%)
		Interaction with ADGRB1. /evidence=ECO:0000269\|PubMed:10748157	726..808		7/81 (9%)
		PDZ_signaling	726..807	CDD:238492	7/80 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..843		5/21 (24%)
		PDZ_signaling	849..935	CDD:238492	17/85 (20%)
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000269\|PubMed:10748157, ECO:0000269\|PubMed:16904289	851..938		17/86 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..976		12/38 (32%)
		PDZ_signaling	1022..1100	CDD:238492	11/77 (14%)
		Red1	<1132..1461	CDD:311769	69/415 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1170..1481		57/341 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900