DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42797 and HECTD1

DIOPT Version :9

Sequence 1:NP_572574.2 Gene:CG42797 / 31905 FlyBaseID:FBgn0261931 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_056197.3 Gene:HECTD1 / 25831 HGNCID:20157 Length:2610 Species:Homo sapiens


Alignment Length:1658 Identity:309/1658 - (18%)
Similarity:523/1658 - (31%) Gaps:547/1658 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 DDPKEEEAFYEARNGNESDELEQAFQSALTLTNDVHVSVSEVEEHEPPLASRNQEVAEVEEQQQQ 119
            |.||:|      :.|.....::|..::|...|:  ::|:|..|     |......|.|     .|
Human  1201 DPPKDE------KQGWRHVRIKQMGKNASGQTH--YLSLSGFE-----LYGTVNGVCE-----DQ 1247

  Fly   120 LGACALPQPSEASLTGSKETREPRHHQTLLSTKSCE--TPANNATLSPTNSYNGSIGSDGGSSVG 182
            ||..|  :.:||:|         |..:.|:.::..:  .|...........:....||..|....
Human  1248 LGKAA--KEAEANL---------RRQRRLVRSQVLKYMVPGARVIRGLDWKWRDQDGSPQGEGTV 1301

  Fly   183 GGARRKSW-TLSPQSGGSTPL-SGAKKK-----------TKTGAPTTTLSNANGDGFNLWVAREC 234
            .|.....| .::..:|||... .||:.|           ....:|....|..:|           
Human  1302 TGELHNGWIDVTWDAGGSNSYRMGAEGKFDLKLAPGYDPDTVASPKPVSSTVSG----------- 1355

  Fly   235 FETVPAEMVDTLSMAEVDEEVDEEEDEEAAAVESLLGAAA---ALQASAHVQ------RRQQQQH 290
                     .|.|.:.:.:....::...||...|..|:::   ::.:|:.:.      .|:.:..
Human  1356 ---------TTQSWSSLVKNNCPDKTSAAAGSSSRKGSSSSVCSVASSSDISLGSTKTERRSEIV 1411

  Fly   291 HQHLRQPSPPQHRPLERSWPPRAVGRDLKLQGDVFQFDILDTDERLAEEMAQGSGSSNNSPLATP 355
            .:|........|.|:.                      :|.:.|.:.:.....|.|::.|.|...
Human  1412 MEHSIVSGADVHEPIV----------------------VLSSAENVPQTEVGSSSSASTSTLTAE 1454

  Fly   356 PVRFKPLLKKKIGPDSYINTISTQKVPVHQSYEFPTFPSSSAVGSSS------SSPNSLQFPYLR 414
              ......::|:||||.:.|              |...|:.::|..|      ||.:.|......
Human  1455 --TGSENAERKLGPDSSVRT--------------PGESSAISMGIVSVSSPDVSSVSELTNKEAA 1503

  Fly   415 QHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSPPS---GCSTRSASPLDISL----------- 465
            ..|||:.:.||..:.||        ||:...|.|..:   ..|:|..|.|:..:           
Human  1504 SQRPLSSSASNRLSVSS--------LLAAGAPMSSSASVPNLSSRETSSLESFVRRVANIARTNA 1560

  Fly   466 ---------SPEQHSPTRGRGVGGALQDAVPP--GTPTFHGQRPQQRLLKRVGGGAGAGATGGAT 519
                     |.:.::.|.||.|   :..|..|  |..:|...                 .|.|.|
Human  1561 TNNMNLSRSSSDNNTNTLGRNV---MSTATSPLMGAQSFPNL-----------------TTPGTT 1605

  Fly   520 GSPLVCPPTPTHHARRHARLQAVTANSSLASGGAIPSDPPAVSSQLD---------YIYL----- 570
            .:..:...:.|..:........::...||::  .:.:...:.||:.|         |.:|     
Human  1606 STVTMSTSSVTSSSNVATATTVLSVGQSLSN--TLTTSLTSTSSESDTGQEAEYSLYDFLDSCRA 1668

  Fly   571 ------------------QDGGQEQGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALM 617
                              :|...|...::..|...:...|.||:..|:.:.:.....|.......
Human  1669 STLLAELDDDEDLPEPDEEDDENEDDNQEDQEYEEVMILRRPSLQRRAGSRSDVTHHAVTSQLPQ 1733

  Fly   618 EPGTGTVSGSSGAGAAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHH 682
            .|          || ||..|:....|...::.|        .|..:|.                .
Human  1734 VP----------AG-AGSRPIGEQEEEEYETKG--------GRRRTWD----------------D 1763

  Fly   683 RQQLDRRYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAIL--MLCRPD--- 742
            ...|.|::.::.....           |....:|...|.....||....|..:|  :.|.|.   
Human  1764 DYVLKRQFSALVPAFD-----------PRPGRTNVQQTTDLEIPPPGTPHSELLEEVECTPSPRL 1817

  Fly   743 -----FYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELP- 801
                 ...|..|.|..|.:.|..:.:.:.|.::.: ..|....:.:|.......|:..|.||:. 
Human  1818 ALTLKVTGLGTTREVELPLTNFRSTIFYYVQKLLQ-LSCNGNVKSDKLRRIWEPTYTIMYREMKD 1881

  Fly   802 ----------SCWETK-------LDQSGKQFFIDHQHRR--TSFMDPRLPVECPRVVRHRQQHSQ 847
                      .||..:       .|:..|...|.:..:.  .:|:.........:.:|..:..||
Human  1882 SDKEKENGKMGCWSIEHVEQYLGTDELPKNDLITYLQKNADAAFLRHWKLTGTNKSIRKNRNCSQ 1946

  Fly   848 QQSSVGYYYPDLVDGNCLSATSGHINASPASSV--SGVPPLPPPRPSSSSSSSRSSHGHGHNCNT 910
            ..::    |.|.    |...|...:|....|::  |.:..|...:|.:.:       |:|.|   
Human  1947 LIAA----YKDF----CEHGTKSGLNQGAISTLQSSDILNLTKEQPQAKA-------GNGQN--- 1993

  Fly   911 TSAISCALNADRSAYGAAGMASAGATAAGYEDV----PIAYNEKVIAFLRQPNILEILRERQGQH 971
                ||                      |.|||    .|.|   ::|......|.:...:.|.|.
Human  1994 ----SC----------------------GVEDVLQLLRILY---IVASDPYSRISQEDGDEQPQF 2029

  Fly   972 TM------SRQLREKINILRVEGVPALERLGHDLQLT--ILLSLFEQ---EIMGFVPIEER---- 1021
            |.      |:::..||          |:::...|.|.  .|....||   :....:|.|.|    
Human  2030 TFPPDEFTSKKITTKI----------LQQIEEPLALASGALPDWCEQLTSKCPFLIPFETRQLYF 2084

  Fly  1022 ------SPQGSPVLNSRMP-----QRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRS 1075
                  :.:....|.:|..     .|.....|||...:.|          .|:..|: ::.:.|.
Human  2085 TCTAFGASRAIVWLQNRREATVERTRTTSSVRRDDPGEFR----------VGRLKHE-RVKVPRG 2138

  Fly  1076 HLLEDAFRRIMS--ANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSREL------------- 1125
            ..|.:....:|.  |::|.:    |.|.:..|||... ||:.||:.|::.|.             
Human  2139 ESLMEWAENVMQIHADRKSV----LEVEFLGEEGTGL-GPTLEFYALVAAEFQRTDLGAWLCDDN 2198

  Fly  1126 --------------FNP--YY-----GLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLA 1169
                          ..|  ||     |||        |......|..::.....|.|.|..|...
Human  2199 FPDDESRHVDLGGGLKPPGYYVQRSCGLF--------TAPFPQDSDELERITKLFHFLGIFLAKC 2255

  Fly  1170 LVHQYLLDAFFTRPFYKALLR-------------------LPVALSDLESLDNEFHQSLQ----- 1210
            :....|:|...::||:|.:..                   |....|..|:...|.|.||.     
Human  2256 IQDNRLVDLPISKPFFKLMCMGDIKSNMSKLIYESRGDRDLHCTESQSEASTEEGHDSLSVGSFE 2320

  Fly  1211 -------------------------W----------------IRD-------------------- 1214
                                     |                |:|                    
Human  2321 EDSKSEFILDPPKPKPPAWFNGILTWEDFELVNPHRARFLKEIKDLAIKRRQILSNKGLSEDEKN 2385

  Fly  1215 ---------NDIGTG-----VDLGLT--FCVTEELLG-SVVDRELKPGGKNIIINEKNKKEYLER 1262
                     |..|:|     .||||.  ||.:..:.| :.||  |||.|::.:|...|.:||::.
Human  2386 TKLQELVLKNPSGSGPPLSIEDLGLNFQFCPSSRIYGFTAVD--LKPSGEDEMITMDNAEEYVDL 2448

  Fly  1263 MIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLN-----TEYR 1322
            |..:.:..|:|:|.|:...||.:|.....:|.|...|:::::.|.   .:..|...     ||.:
Human  2449 MFDFCMHTGIQKQMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGN---QSPSWAAEDIINYTEPK 2510

  Fly  1323 SGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNA 1387
            .||..:....:.|.:|:...|:::|...|||.||.|::|..|.:.|.    ||...:.|....:|
Human  2511 LGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLH----PRLTVVRKVDATDA 2571

  Fly  1388 -LPRAHTCFNRLDLPPYPTPELLYEKLLLAVEE 1419
             .|..:||.:.|.||.|.:.|::.|:||.|..|
Human  2572 SYPSVNTCVHYLKLPEYSSEEIMRERLLAATME 2604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42797NP_572574.2 WW 638..667 CDD:278809 4/28 (14%)
HECTc 1068..1424 CDD:238033 110/496 (22%)
HECTc 1092..1423 CDD:214523 105/470 (22%)
HECTD1NP_056197.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..269
Ank_2 366..457 CDD:403870
ANK repeat 366..393 CDD:293786
ANK 1 395..424
ANK repeat 396..426 CDD:293786
ANK 2 426..455
ANK repeat 428..457 CDD:293786
ANK 3 459..491
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 489..513
ANK 4 579..612
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 627..657
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 707..748
Sad1_UNC 1107..1240 CDD:400199 12/51 (24%)
MIB_HERC2 1277..1335 CDD:399589 11/57 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1343..1406 10/82 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1433..1483 13/65 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1496..1515 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1592..1611 5/35 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1674..1757 16/101 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1777..1797 3/30 (10%)
BTHB 1892..1965 CDD:408209 13/80 (16%)
K-box 2029..2103 15/83 (18%)
HECTc 2131..2608 CDD:238033 110/497 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2297..2318 6/20 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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