DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG42797 and NEDD4L

DIOPT Version :9

Sequence 1:NP_572574.2 Gene:CG42797 / 31905 FlyBaseID:FBgn0261931 Length:1426 Species:Drosophila melanogaster
Sequence 2:XP_006722489.1 Gene:NEDD4L / 23327 HGNCID:7728 Length:1019 Species:Homo sapiens


Alignment Length:1194 Identity:331/1194 - (27%)
Similarity:495/1194 - (41%) Gaps:374/1194 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   293 HLRQPSPPQHRP----------------------LERSWPPRAVGRDLKLQGDVFQFDILDTDER 335
            ||....|...||                      |:.::.|:..|:|.:           ::|:|
Human   140 HLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEE-----------NSDQR 193

  Fly   336 LAEEMAQG--------SGSSNNSPLATPPVRFKPLLKKKI---GPDSYINTISTQKVPVHQSYEF 389
              ::|..|        |.|.:...|..||:  .|..::|:   |...|:|. :.:....|:    
Human   194 --DDMEHGWEVVDSNDSASQHQEELPPPPL--PPGWEEKVDNLGRTYYVNH-NNRTTQWHR---- 249

  Fly   390 PTFPSSSAVGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSPPSGCS 454
               ||...|  ||.|.|:::                   ..::|.|..|.               
Human   250 ---PSLMDV--SSESDNNIR-------------------QINQEAAHRRF--------------- 275

  Fly   455 TRSASPLDISLSPEQHSPTRGRGVGGALQDAVPPGTPTFHGQRPQQRLLKRVGGGAGAGATGGAT 519
             ||...:...|.||   |:.|..|                 ..|.:.:.:.|      ...|.:.
Human   276 -RSRRHISEDLEPE---PSEGGDV-----------------PEPWETISEEV------NIAGDSL 313

  Fly   520 GSPLVCPPTPTHHARRHA----------RLQAVTANSSLASGGAIPSDPPAVSSQLDYIYLQDGG 574
            |  |..||.|.....|.:          |||....::.......|..:|   ||:|....:.|..
Human   314 G--LALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREP---SSRLRSCSVTDAV 373

  Fly   575 QEQGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSGSSGAGAAGEPPLP 639
            .|||.                :|..||.|..|.::...|.....|....|..:        |.||
Human   374 AEQGH----------------LPPPSAPAGRARSSTVTGGEEPTPSVAYVHTT--------PGLP 414

  Fly   640 PAWEARMDSHGRIFYIDHTTRTTSWQRP-------GAAPSGGPAGREQHHRQQLDRRYQSIRRTI 697
            ..||.|.|:.||.:|::|..|||:|.||       ||:.|                         
Human   415 SGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGS------------------------- 454

  Fly   698 TNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAA 762
                          :.|||.:...|....|.:...|.:         :|....|.|     :::.
Human   455 --------------ATNSNNHLIEPQIRRPRSLSSPTV---------TLSAPLEGA-----KDSP 491

  Fly   763 LKHMVMRIRRDPPCFQRYQYN--KDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRTS 825
            ::..|.....:|...|...||  |....:..:|      ||..||.::..:|:.|||||..:.|:
Human   492 VRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSF------LPPGWEMRIAPNGRPFFIDHNTKTTT 550

  Fly   826 FMDPRL--PVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGVPPLPP 888
            :.||||  ||                                     |:.:..:.:.:.:.||||
Human   551 WEDPRLKFPV-------------------------------------HMRSKTSLNPNDLGPLPP 578

  Fly   889 PRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIA 953
            ..........|:.:     .:.:|.:.|..|..|                  |.|| :|:.|:..
Human   579 GWEERIHLDGRTFY-----IDHSSQVLCGENDTR------------------ESVP-SYDSKITQ 619

  Fly   954 F----LRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMG 1014
            :    |:.|.|..                           ||:                      
Human   620 WEDPRLQNPAITG---------------------------PAV---------------------- 635

  Fly  1015 FVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLE 1079
                                     |:.|:|:.|...|.:||  |.....|::.::.:.|:::.|
Human   636 -------------------------PYSREFKQKYDYFRKKL--KKPADIPNRFEMKLHRNNIFE 673

  Fly  1080 DAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQ 1144
            :::|||||..:.|:.:.||.:.:::|:||||||.:||:|||||:|:||||||||||||.|.||:|
Human   674 ESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQ 738

  Fly  1145 VSPLSAFVDNCH-DWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQS 1208
            ::|.|...:..| .:|.|.|||.|||:.|..|||.||.|||||.:|...:.|:|:||:|:|::.|
Human   739 INPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNS 803

  Fly  1209 LQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQ 1273
            |:||.:||   ..:|.|.||:.||..|.....:|||.|..|::..:||:||::.:|:||....||
Human   804 LKWILEND---PTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQ 865

  Fly  1274 EQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQV 1338
            :|..:.:.||.|::...|:.:||..||||::.|..::|.||||.::.|::||..||.||.|||:.
Human   866 KQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKA 930

  Fly  1339 IERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPY 1403
            :.....|:|:||||||||||.:|..||:.|.||.||:.|.||:||.|..||||||||||||||||
Human   931 VLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPY 995

  Fly  1404 PTPELLYEKLLLAVEETNTF-GIE 1426
            .|.|.|.||||:|||....| |::
Human   996 ETFEDLREKLLMAVENAQGFEGVD 1019

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42797NP_572574.2 WW 638..667 CDD:278809 14/28 (50%)
HECTc 1068..1424 CDD:238033 177/357 (50%)
HECTc 1092..1423 CDD:214523 169/331 (51%)
NEDD4LXP_006722489.1 C2_NEDD4_NEDD4L 21..179 CDD:175999 6/38 (16%)
WW 224..250 CDD:278809 5/33 (15%)
WW 413..442 CDD:278809 14/28 (50%)
WW 526..556 CDD:238122 12/29 (41%)
WW 575..625 CDD:197736 14/73 (19%)
HECTc 662..1016 CDD:238033 176/356 (49%)
HECTc 686..1015 CDD:214523 169/331 (51%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.