DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and WWC1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_011532787.1	Gene:	WWC1 / 23286	HGNCID:	29435	Length:	1185	Species:	Homo sapiens

Alignment Length:	919	Identity:	173/919 - (18%)
Similarity:	265/919 - (28%)	Gaps:	421/919 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   635 EPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRYQSIRRTITN 699
            |.|||..||...|..|:::|||||.|||||..|
Human     5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP-------------------------------- 37

  Fly   700 ESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAALK 764

Human    38 ----------------------------------------------------------------- 37

  Fly   765 HMVMRIRRDPPCFQRYQYNKDLVALVNTFAQ-MSRELPSCWETKLDQSGKQFFIDHQHRRTSFMD 828
                          |.:|.|.|     |||. :|.|||..||...|.....:||||..:.|...|
Human    38 --------------RDRYTKPL-----TFADCISDELPLGWEEAYDPQVGDYFIDHNTKTTQIED 83

  Fly   829 PRL-----------------------PVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSG 870
            ||:                       ..|..:|.:.|.:.:||:      |..      |.|...
Human    84 PRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELAQQE------YQQ------LHAVWE 136

  Fly   871 HINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGA 935
            |...|..|.|||           |||||:                         |....:.:..|
Human   137 HKLGSQVSLVSG-----------SSSSSK-------------------------YDPEILKAEIA 165

  Fly   936 TAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQ 1000
            ||                                        :.::|.|:.|.|    .|.|:||
Human   166 TA----------------------------------------KSRVNKLKREMV----HLQHELQ 186

  Fly  1001 LTILLSLFEQEIMGFVPIEE-----RSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKG 1060
                   |::.  ||..:::     ...|||..|:             :.:|.||.  .|...|.
Human   187 -------FKER--GFQTLKKIDKKMSDAQGSYKLD-------------EAQAVLRE--TKAIKKA 227

  Fly  1061 YGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGG-PSREFFFLLSRE 1124
            ...|..:.:..|:...:|:|.||         ..||..:.||.:...|:... |..:.:..:|.:
Human   228 ITCGEKEKQDLIKSLAMLKDGFR---------TDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQ 283

  Fly  1125 LFNPYYGLFEYSANDTYTVQVSPLSAFVD-----NCHDWFRFSGRVLGLA------LVHQYLLDA 1178
              ....|.|..::|:....:|.....:.:     :|.         .|.|      |.|..|..|
Human   284 --TDISGSFGINSNNQLAEKVRLRLRYEEAKRRLSCQ---------CGQATPSNSELTHYQLPQA 337

  Fly  1179 --------FFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLG 1235
                    :....|..:|.|..:.|..:.|..|   ..|:||.:..|..
Human   338 SSKTARHLYLDSHFLFSLKRTTLNLGSVPSCRN---ACLRWIANLKIQL---------------- 383

  Fly  1236 SVVDRELKPG------GKNIIINEKNKKEYLERM-----IKW-------------RLERGVQ--E 1274
            :.:|.|..||      .:.|:|||  |:|.|:.|     .||             |||:.:|  .
Human   384 AKLDSEAWPGVLDSERDRLILINE--KEELLKEMRFISPRKWTQGEVEQLEMARKRLEKDLQAAR 446

  Fly  1275 QTES---------------LVRGFYE------VIDSRLVSVFDARELELVIAGTAEIDTNDWR-- 1316
            .|:|               |||...|      .:.|:|.|:  :..::.:.:|::.......|
Human   447 DTQSKALTERLKLNSKRNQLVRELEEATRQVATLHSQLKSL--SSSMQSLSSGSSPGSLTSSRGS 509

  Fly  1317 -----LNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPR- 1375
                 |::...:.:.|      .::...|:..:|.:.::             .|..|.|:||.|
Human   510 LVASSLDSSTSASFTD------LYYDPFEQLDSELQSKV-------------EFLLLEGATGFRP 555

  Fly  1376 RFCI--------------EKWGKPNAL------PRAHTCF---NRLDLPPYPTPELLYEKLLLAV 1417
            ..||              |..|:..||      |::.|..   :.|..|..|...|:.:.||...
Human   556 SGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSLSSPSPPCSPLMADPLLAGD 620

  Fly  1418 EETNTFGIE 1426
            ...|:...|
Human   621 AFLNSLEFE 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	16/28 (57%)
		HECTc	1068..1424	CDD:238033	87/453 (19%)
		HECTc	1092..1423	CDD:214523	82/428 (19%)
WWC1	XP_011532787.1	WW	9..39	CDD:238122	16/140 (11%)
		WW	55..84	CDD:278809	10/28 (36%)
		ALDH-SF	429..>481	CDD:299846	10/51 (20%)
		C2_Kibra	721..844	CDD:176062
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900