DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42797 and HECW1

DIOPT Version :9

Sequence 1:NP_572574.2 Gene:CG42797 / 31905 FlyBaseID:FBgn0261931 Length:1426 Species:Drosophila melanogaster
Sequence 2:XP_016867371.1 Gene:HECW1 / 23072 HGNCID:22195 Length:1639 Species:Homo sapiens


Alignment Length:1475 Identity:576/1475 - (39%)
Similarity:745/1475 - (50%) Gaps:316/1475 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 SDELEQAFQSALTLTNDVHVSVSEVEEHEPPLASRNQEVAEVEEQQQQLGACALPQPSEASLTGS 136
            :|.:....|....:|:.:|    ..::.|..| |...|.|::::...          :....:||
Human   361 TDHVSGQLQFRFEITSSIH----PADDEEISL-STEPESAQIQDSPM----------NNLMESGS 410

  Fly   137 KETREPRHHQTLLSTKSCETPANNATLSPTNSYNGSIGSDGGSSVGGGARRKSWTLSPQSGGSTP 201
            .|.|.             |.|.::.:..|...        |..||..|...:|..|      |.|
Human   411 GEPRS-------------EAPESSESWKPEQL--------GEGSVPDGPGNQSIEL------SRP 448

  Fly   202 LSGAKKKTKTGAPTTTLSNANGDGFNLWVARECFETVPAEMVDTLSMAEVDEEVDEEEDEEAAAV 266
            ...|...|:.|..........|.|       |....|..::....|..|:.|::|..|:..|..:
Human   449 AEEAAVITEAGDQGMVSVGPEGAG-------ELLAQVQKDIQPAPSAEELAEQLDLGEEASALLL 506

  Fly   267 ESLLGAAAA------LQASAHVQRRQQQQHHQHLRQPSPPQHRPLERSWPPRAVGRDLKLQGDVF 325
            |.  |.|.|      |:..|..|.|..::..:                       ::.:.:||| 
Human   507 ED--GEAPASTKEEPLEEEATTQSRAGREEEE-----------------------KEQEEEGDV- 545

  Fly   326 QFDILDTDERLAEEMAQGSGSSNNSPLATPPVRFKPLLKKKIGPDSYINTISTQKVPVHQSYEFP 390
                        ..:.||.|.          ::.:..:|:|..|.|                 .|
Human   546 ------------STLEQGEGR----------LQLRASVKRKSRPCS-----------------LP 571

  Fly   391 TFPSSSAVGSSSSSPNSLQFPYLRQHRPL--TRALSNGKASSSEEQASPRLLLSPKRPRSPPSGC 453
            .....:.:.|:...|.:.:..|:|.|..|  ..:...|.|:..|:.|.....|.....:...|..
Human   572 VSELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDGLSEV 636

  Fly   454 STRSASPLDISLSPEQ----------------HSPTRGRGVGGALQDA-VPPGTPTFHGQRPQQR 501
            .|.:|.|..:....|:                |.|:.   ..||.||. ..|.|.:.....|:| 
Human   637 DTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSL---ANGAAQDGDTHPSTGSESDSSPRQ- 697

  Fly   502 LLKRVGGGAGAGATGGATGSPLV----CPPTPTHHARRHA------------RLQAVTANSSLAS 550
                 ||.........:..||..    |..|..:.:..::            |..:.|..||:.|
Human   698 -----GGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRFSSVDS 757

  Fly   551 GGAIPSDPPAVSSQLDYIYLQDGGQEQGQEQSDEVVHISSTRLPSIPERSAAAAAA---AAAAAA 612
              |..|:....|||.|         |:.:..:.|.|. .|.:.|.:...|...|..   ..||.:
Human   758 --AKISESTVFSSQDD---------EEEENSAFESVP-DSMQSPELDPESTNGAGPWQDELAAPS 810

  Fly   613 GAALMEPG--TGTVSGSSGAGAAGEP--------------------------PLPPAWEARMDSH 649
            |.....|.  ...|:|.|.......|                          ||||.||||:|||
Human   811 GHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSH 875

  Fly   650 GRIFYIDHTTRTTSWQRPGAA--PSGGPAGREQHHRQQLDRRYQSIRRTITNE-----SRAAQLY 707
            ||:||:||..|||:||||.||  |.|..........:||:||||:|:|||..|     |.:....
Human   876 GRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEEDSGSQSCE 940

  Fly   708 NLPTSANSNANSTAPA---------------APPPATAI-----HPAILMLCRPDFYSLLHTNEA 752
            ..|........|.:.|               :|..:..|     .||:..:..|:|:::||.|.:
Human   941 QAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYS 1005

  Fly   753 ALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFI 817
            |..::..:..||||::::|||...|:|||:|:|||..:|.||....|||..||.|.||.||.||:
Human  1006 AYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFV 1070

  Fly   818 DHQHRRTSFMDPRLPVECPRVVRH--RQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSV 880
            ||..|.|:|:|||:|::..|:..|  .:||.|:..|                    .:|..||.|
Human  1071 DHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRS--------------------YSAGEASEV 1115

  Fly   881 S---GVPPLPPPRPSSS-SSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYE 941
            |   |...|  .||..| .::.||.|.|                                    |
Human  1116 SRNRGASLL--ARPGHSLVAAIRSQHQH------------------------------------E 1142

  Fly   942 DVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQLTILLS 1006
            .:|:|||:|::||||||||.|:|:|||.....:..|||||:.:|.||...||:|..|..|.||||
Human  1143 SLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLS 1207

  Fly  1007 LFEQEIMGFVPIEE---------------RSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKL 1056
            |||:|||.:||::.               .|||.||.| .|...|||.|:|||||||||:|||||
Human  1208 LFEEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQNSPGL-QRASARAPSPYRRDFEAKLRNFYRKL 1271

  Fly  1057 ESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLL 1121
            |:||:||||.|:||.|||.||||..|.::|:.::|:|||.:|.|.:..||||||.||||||||||
Human  1272 EAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLL 1336

  Fly  1122 SRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYK 1186
            |:|||||||||||||||||||||:||:||||:|..:|||||||:|||||:|||||||||||||||
Human  1337 SQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYK 1401

  Fly  1187 ALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIII 1251
            ||||||..|||||.||.||||||||::||:| |.: |.|||.|.||:.|.|.:||||.||.|..:
Human  1402 ALLRLPCDLSDLEYLDEEFHQSLQWMKDNNI-TDI-LDLTFTVNEEVFGQVTERELKSGGANTQV 1464

  Fly  1252 NEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWR 1316
            .|||||||:|||:|||:||||.:|||:||||||||:||||||||||||||||||||||||.||||
Human  1465 TEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWR 1529

  Fly  1317 LNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEK 1381
            .|||||.||||.|.||.|||..:|||:||||||||||||||||:|||||:|||||.|.|||||||
Human  1530 NNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEK 1594

  Fly  1382 WGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            |||..:|||||||||||||||||:..:||||||.|||||:|||:|
Human  1595 WGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42797NP_572574.2 WW 638..667 CDD:278809 21/28 (75%)
HECTc 1068..1424 CDD:238033 270/355 (76%)
HECTc 1092..1423 CDD:214523 257/330 (78%)
HECW1XP_016867371.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 512 1.000 Domainoid score I316
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 899 1.000 Inparanoid score I385
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 1 1.000 - - otm40421
orthoMCL 1 0.900 - - OOG6_105324
Panther 1 1.100 - - O PTHR11254
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1661
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.860

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