DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and Hectd2

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001156943.1	Gene:	Hectd2 / 226098	MGIID:	2442663	Length:	775	Species:	Mus musculus

Alignment Length:	417	Identity:	124/417 - (29%)
Similarity:	203/417 - (48%)	Gaps:	57/417 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1042 RRDFEAKLRSFYRK--LESKGYGQGPHK----LKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAV 1100
            :||.|.::.|..|:  ::.....|.|..    |.:.:||:||:.|:... ::..:.||:: :|.|
Mouse   384 QRDSEQQMISIARQSLVDKVSRRQRPDMNMLFLNMKVRRTHLVSDSLDE-LTRKRADLKK-KLKV 446

  Fly  1101 LWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDW------- 1158
            .:..|.|||.||.::|:|.||.|::|:|.||:|.|..:              .:|| |
Mouse   447 TFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKD--------------SHCH-WFSSFKCD 496

  Fly  1159 ----FRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLE--------SLDN------EF 1205
                ||..|.::|||:.:...||..|....||.||..||..||..        ::|:      |.
Mouse   497 NYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPVVPSDQSTPVGICSVTIDDLCQVMPEL 561

  Fly  1206 HQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLER 1270
            ...|:.:...:.....|...||.|.:|..|.:....|||||..|.:..:|::||::....:.|.:
Mouse   562 AHGLKELLSYEGNVEEDFYSTFQVFQEEFGVIKSYNLKPGGDKIPVTNQNRREYVQLYTDFLLNK 626

  Fly  1271 GVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWF 1335
            .:.:|..:...||:.|..|..:.:....|:|:::.|:.|:|.:..:.:|:| .||......|.:|
Mouse   627 SIYKQFAAFYCGFHSVCASNALMLLRPEEVEILVCGSPELDMHALQRSTQY-DGYAKTDLTIRYF 690

  Fly  1336 WQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEK-WGKPNALPRAHTCFNRLD 1399
            |.|:..|..|.:.:||.|.||:..:|..|.:.|       .|.|.| ....|.||.||||||:|.
Mouse   691 WDVVLGFPLELQKKLLHFTTGSDRVPVGGMADL-------NFKISKNETSTNWLPVAHTCFNQLC 748

  Fly  1400 LPPYPTPELLYEKLLLAVEETNTFGIE 1426
            ||||.:.:.|.:||::.:..:..||:|
Mouse   749 LPPYKSKKDLKQKLIIGISNSEGFGLE 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809
		HECTc	1068..1424	CDD:238033	114/381 (30%)
		HECTc	1092..1423	CDD:214523	108/356 (30%)
Hectd2	NP_001156943.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		HECTc	416..773	CDD:238033	114/381 (30%)
		HECTc	439..772	CDD:214523	108/356 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810