Protein Alignment Hecw and Ube3a

DIOPT Version :10

• Sequence 1: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_035798.2
• Gene: Ube3a / 22215
• MGIID: 105098
• Length: 870
• Species: Mus musculus
• Alignment Length: 395
• Identity: 129/395 - (32%)
• Similarity: 202/395 - (51%)
• Gaps: 29/395 - (7%)

  Fly  1045 FEAKLRSFYRK----LESKGYGQ--GPHKLKLHIRRSHLLEDAFRR---IMSANKKDLQRGRLAV 1100
            ::.::|.:..:    |.|...||  .|: |:|.:||.|:::||..|   |...|..||:: :|.|
Mouse   490 YDNRIRMYSERRITVLYSLVQGQQLNPY-LRLKVRRDHIIDDALVRLEMIAMENPADLKK-QLYV 552

  Fly  1101 LWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRV 1165
            .::.|:|:|.||.|:|||.|:..|:|||..|:|.|. ..|.....:| |:|  .....|...|.|
Mouse   553 EFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYD-EATKLFWFNP-SSF--ETEGQFTLIGIV 613

  Fly  1166 LGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVT 1230
            ||||:.:..:||..|....|:.|:.......||.......:|||:.:.:.:.....|:.:||.::
Mouse   614 LGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGSVEDDMMITFQIS 678

  Fly  1231 E-ELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVI-DSRLVS 1293
            : :|.|:.:..:||..|..|.|..:|:||::.....:.|.:.|::|.::..|||:.|. :|.|..
Mouse   679 QTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 743

  Fly  1294 VFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTS 1358
            :|...|:||:|.|:..:|.......|||..||.....||..||:::..|::||:...|||.|||.
Mouse   744 LFRPEEIELLICGSRNLDFQALEETTEYDGGYTRESVVIREFWEIVHSFTDEQKRLFLQFTTGTD 808

  Fly  1359 SIPYEGFSALR---GSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEET 1420
            ..|..|...|:   ...||         ....||.:|||||.|.||.|.:.|.|.|:||.|:...
Mouse   809 RAPVGGLGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYA 864

  Fly  1421 NTFGI 1425
            ..||:
Mouse   865 KGFGM 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021
		WW	638..667	CDD:459800
		HECW1_helix	738..794	CDD:465766
		HECTc	1068..1424	CDD:238033	121/363 (33%)
Ube3a	NP_035798.2	AZUL	27..81	CDD:465173
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..223
		HECTc	518..868	CDD:238033	121/363 (33%)