DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and Wwc1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_740749.1	Gene:	Wwc1 / 211652	MGIID:	2388637	Length:	1104	Species:	Mus musculus

Alignment Length:	894	Identity:	169/894 - (18%)
Similarity:	245/894 - (27%)	Gaps:	436/894 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly   635 EPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRYQSIRRTITN 699
            |.|||..||...|..|:::||||..|||||..|
Mouse     5 ELPLPEGWEEARDFDGKVYYIDHRNRTTSWIDP-------------------------------- 37

  Fly   700 ESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAALK 764

Mouse    38 ----------------------------------------------------------------- 37

  Fly   765 HMVMRIRRDPPCFQRYQYNKDLVALVNTFAQ-MSRELPSCWETKLDQSGKQFFIDHQHRRTSFMD 828
                          |.:|.|.|     |||. :|.|||..||...|.....:||||..:.|...|
Mouse    38 --------------RDRYTKPL-----TFADCISDELPLGWEEAYDPQVGDYFIDHNTKTTQIED 83

  Fly   829 PRL-----------------------PVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSG 870
            ||:                       ..|..:|.:.|.:.:||:      |..      |.|...
Mouse    84 PRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELAQQE------YQQ------LHAVWE 136

  Fly   871 HINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGA 935
            |...|..|.|||           |||||:                         |....:.:..|
Mouse   137 HKLGSQVSLVSG-----------SSSSSK-------------------------YDPEILKAEIA 165

  Fly   936 TAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQ 1000
            ||                                        :.::|.|:.|.|    .|.|:||
Mouse   166 TA----------------------------------------KSRVNKLKREMV----HLQHELQ 186

  Fly  1001 LTILLSLFEQEIMGFVPIEER--SPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQ 1063
            ..      |:.......|:||  ..||...|:             :.:|.||.  .|...|....
Mouse   187 FK------ERGFQTLKKIDERMSDAQGGYKLD-------------EAQAVLRE--TKAIKKAITC 230

  Fly  1064 GPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGG-PSREFFFLLSRELFN 1127
            |..:.:..|:...:|:|.||         ..||..:.||.:...|:... |..:.|..:|.:  .
Mouse   231 GEKEKQDLIKSLAMLKDGFR---------TDRGSHSDLWSSSSSLESSSFPMPKQFLDVSSQ--T 284

  Fly  1128 PYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLP 1192
            ...|.|..|:|:....:|.                     |.|.::            :|..|:.
Mouse   285 DISGSFSTSSNNQLAEKVR---------------------LRLRYE------------EAKRRIA 316

  Fly  1193 VALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKK 1257
            .....|..||:|     .|       .||            |.|..||       .|:|||  |:
Mouse   317 NLKIQLAKLDSE-----AW-------PGV------------LDSERDR-------LILINE--KE 348

  Fly  1258 EYLERM-----IKW-------------RLERGVQ--EQTES---------------LVRGFYE-- 1285
            |.|:.|     .||             |||:.:|  ..|:|               |||...|
Mouse   349 ELLKEMRFISPRKWTQGEVEQLEMARRRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEAT 413

  Fly  1286 ----VIDSRLVSVFDARELELVIAGTA-----------EIDTNDWRLNTEYRSGYHDNHQVIVWF 1335
                .:.|:|.|:  :..::.:.:|::           ...:.|...:..:...|:|.      |
Mouse   414 RQVATLHSQLKSL--SSSMQSLSSGSSPGSLTSSRGSLAASSLDSSTSASFTDLYYDP------F 470

  Fly  1336 WQVIERFSNEQRLRLLQFVTG---------------TSSIPYEGFS---ALRGSTGPRRFCIEKW 1382
            .|:.....::..|..|:..||               ..:...||.|   |||..:|
Mouse   471 EQLDSELQSKVELLFLEGATGFRPSGCITTIHEDEVAKTQKAEGGSRLQALRSLSG--------- 526

  Fly  1383 GKPNALPRAHTCF---NRLDLPPYPTPELLYEKLL--------LAVEET 1420
                 .||:.|..   :.|..|..|...|:.:.||        |..|:|
Mouse   527 -----TPRSMTSLSPRSSLSSPSPPCSPLITDPLLTGDAFLAPLEFEDT 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	15/28 (54%)
		HECTc	1068..1424	CDD:238033	85/435 (20%)
		HECTc	1092..1423	CDD:214523	80/411 (19%)
Wwc1	NP_740749.1	WW	9..39	CDD:238122	15/140 (11%)
		WW	55..84	CDD:278809	10/28 (36%)
		ALDH-SF	378..>420	CDD:299846	8/41 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..449		1/19 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..547		12/51 (24%)
		C2_Kibra	661..784	CDD:176062
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..949
		Interaction with histone H3. /evidence=ECO:0000250	836..1104
		Interaction with PRKCZ. /evidence=ECO:0000250	945..988
		ADDV motif	1102..1104
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900