DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and Hace1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_006512697.1	Gene:	Hace1 / 209462	MGIID:	2446110	Length:	921	Species:	Mus musculus

Alignment Length:	407	Identity:	163/407 - (40%)
Similarity:	244/407 - (59%)	Gaps:	32/407 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly  1027 PVLNSRMPQ--RAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLH----------IRRSHLLE 1079
            |.|.||...  :|.|     |:.:...||..|.|   || |....:|          :.|..:..
Mouse   521 PELMSRFMHIIKAQP-----FKDRCEWFYEHLHS---GQ-PDSDMVHRPVSENDILLVHRDSIFR 576

  Fly  1080 DAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQ 1144
            .:...:..||...|::| :||.:..|||:.. |..||:|.:||.|:.||.|.||..||:.| |.|
Mouse   577 SSCEIVSKANCAKLKQG-IAVRFHGEEGMGQ-GVVREWFDILSNEIVNPDYALFTQSADGT-TFQ 638

  Fly  1145 VSPLSAFVDNCH-DWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQS 1208
            .:. :::|:..| ::|||:|::|||||.|:.|::.:|||.|||.:|.:||...|:.|:|.|:.::
Mouse   639 PNS-NSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKN 702

  Fly  1209 LQWIRDNDIGTGVDLG--LTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERG 1271
            ||||.||||.   |||  |||.|..::.|::.:..|||||.:|::.:.||.||::.:.:.|:.|.
Mouse   703 LQWILDNDIS---DLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRA 764

  Fly  1272 VQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFW 1336
            :|.|..:.::||:..|...|:.:||..||||:::|..|||.|||..||||.|||.....||.|||
Mouse   765 IQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWIKNTEYTSGYEREDPVIQWFW 829

  Fly  1337 QVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWG-KPNALPRAHTCFNRLDL 1400
            :|:|..:.|:|:.|||||||:|.:|:.||:.:.|.:|.:.|.|.... .||.||.:.||.|.|.|
Mouse   830 EVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKL 894

  Fly  1401 PPYPTPELLYEKLLLAV 1417
            |.||:.|:|.::||:|:
Mouse   895 PEYPSKEILKDRLLVAL 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809
		HECTc	1068..1424	CDD:238033	149/364 (41%)
		HECTc	1092..1423	CDD:214523	145/330 (44%)
Hace1	XP_006512697.1	ANK repeat	66..95	CDD:293786
		Ank_2	69..194	CDD:372319
		ANK repeat	97..128	CDD:293786
		ANK repeat	130..161	CDD:293786
		ANK repeat	163..194	CDD:293786
		Ank_2	168..263	CDD:372319
		ANK repeat	196..233	CDD:293786
		HECTc	566..915	CDD:238033	148/353 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810