DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and yap-1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001369894.1	Gene:	yap-1 / 181267	WormBaseID:	WBGene00008748	Length:	442	Species:	Caenorhabditis elegans

Alignment Length:	463	Identity:	83/463 - (17%)
Similarity:	142/463 - (30%)	Gaps:	145/463 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   428 ASSSEEQASPRLLLSPKRPRSPPSGCS--------TRSASPLDISLSPEQHSPTRGR-----GVG 479
            :...:.|.|....|.|.:.......||        .:..:||..|...::.:|....     .|.
Worm    14 SQQDKNQFSVHHYLDPNQSIHALISCSEKKYEKNQNQKKNPLPSSYYHQKRNPGSSAHSPYGSVD 78

  Fly   480 GALQDAVPPGTPTFHGQRP-------QQRLLKRVGGGAGAGATGGATGSPLVCPPTPTHHARRHA 537
            .:.:.||.|.......|.|       ...|...|..|..:...           |.|:||...|.
Worm    79 ESSRTAVSPAMDMVSNQAPIHTRQVSAPNLHTSVNNGQSSATV-----------PHPSHHNVHHQ 132

  Fly   538 RLQAVTANSSLASGGAIPSDPPAVSSQLDYIY--LQDGGQEQG--QEQSDEVVHISSTRLPSIPE 598
            ..::|:|.........:||...:||.:.:|.|  |.:..|:||  |:..::.:.:...|.|.:..
Worm   133 HSKSVSALPMTIGYSPVPSHVKSVSHEANYSYAGLSEIPQQQGMMQQNREKSLSLDPMRRPFMTP 197

  Fly   599 RSAAAAAAAAAAAAGAALMEPGTGTVSGSSGAGAAGEPPLPPAWEARMDSHGRIFYIDHTTRTTS 663
            :...                                :.|:|..||...||.|..::.||.::||:
Worm   198 QDVE--------------------------------QLPMPQGWEMCYDSDGVRYFKDHNSKTTT 230

  Fly   664 WQRP----------GAAPS-----------GGPAGR-----EQHH-------------RQQLDRR 689
            |..|          |...:           .|.:.|     .||.             :||:|..
Worm   231 WDDPRLKQQEQTGFGLGENIGQNRYNNCYDNGHSSRSLPSIHQHQQMIPNHPQPQYSSQQQMDYI 295

  Fly   690 YQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAAL 754
            .|.....:..:.:.|||.|         :....:..||..||.|.        ..:::|:::...
Worm   296 QQLQNERMMIQEKNAQLIN---------SGLVDSPQPPYQAISPM--------SSTMMHSHDPNF 343

  Fly   755 AIYN-----RNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQ 814
             :|.     :|:..:.....:.:.|..:|..|.|.|                |..|.........
Worm   344 -MYQQQQQAQNSQQQQTPHTLHQIPNQYQNSQMNDD----------------SAMEVDYSMVSHP 391

  Fly   815 FFIDHQHR 822
            ..:.|||:
Worm   392 QQLQHQHQ 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	11/28 (39%)
		HECTc	1068..1424	CDD:238033
		HECTc	1092..1423	CDD:214523
yap-1	NP_001369894.1	WW	206..236	CDD:238122	12/29 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900