Protein Alignment Hecw and Nedd4

DIOPT Version :10

• Sequence 1: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_001344927.1
• Gene: Nedd4 / 17999
• MGIID: 97297
• Length: 1207
• Species: Mus musculus
• Alignment Length: 1527
• Identity: 394/1527 - (25%)
• Similarity: 596/1527 - (39%)
• Gaps: 539/1527 - (35%)

  Fly    88 DVH------VSVSEVEE---------HEPPLASRNQEVAEVEEQ------QQQLGACALP----- 126
            |.|      :||:.|.:         ..|.:..|:.|..:.:..      |.:.|.| ||
Mouse    32 DTHGQRRPRISVASVVQMRLTPRQAPQAPWVEHRSSESTDKKSSCLQISLQPRYGGC-LPSDTVV 95

  Fly   127 --QPSEASLTGSKETREPRHHQTLLSTKSCETPANNATL-----SPTNSYNGSIGSD-------- 176
              :.|.:|...||:        .:.|:...::..:|.:|     |.:.||:.| |||
Mouse    96 ADRDSTSSTCASKD--------DVCSSSGIDSELDNGSLSNFSASDSGSYSSS-GSDCGSCASLA 151

  Fly   177 -GGSSVGGGARRKSWTLSPQSGGSTPLSGAKKKTKTGAPTTTLSNANGDGFNLWVARECFETVPA 240
             ||||.|.|       :|..||..|..||       ..|:...||.:..          .:|.|.
Mouse   152 SGGSSTGSG-------VSDSSGYETFFSG-------NLPSDNASNRSVP----------VDTTPR 192

  Fly   241 EMV----DTLSMAEVDEEVDEEED--------------EEAAAVESLLGAAAALQASAHVQRRQQ 287
            |::    ..|..|:  |::|...:              :...::.....:.:....::...|...
Mouse   193 EVMCGSPSRLPFAQ--EDLDRGVEIMKLPVSRNAKGPLKRCTSLVIFPRSPSNTPPASPTSRGAY 255

  Fly   288 QQHHQHLRQPSPPQHRPLERSWPPRAVGRDLKLQGDVFQFDILDTDERLAEEMAQGSGSSN---- 348
            |..||.:..|:...|.                                     ..|||:..
Mouse   256 QTSHQLVVSPTETAHH-------------------------------------EDGSGTKGFLST 283

  Fly   349 -------NSPLATP-------PVRFKPLLKKKIGPDSYINTIST--------QKVP-------VH 384
                   :..:.||       |:..|..|:|||       .||.        :|:|       ||
Mouse   284 AVNGLRLSKMVCTPGEVRDVRPLHAKGSLQKKI-------VISNNRPKQTVCEKLPEGFSCVSVH 341

  Fly   385 QSYEFPTFPS-SSAVGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQASPRLLLSP----- 443
            .:.:.||... ::..|..:|....||         |...|.:|..   :::|||.|..:.
Mouse   342 LTQQKPTTSDCANPRGGCTSERLELQ---------LQSDLDHGML---KQRASPCLPTASDMGYH 394

  Fly   444 -------KRPRSPPS---GCSTRSAS-----PLDISLSPEQHSPTRGRGVGGALQDAVPPGTPTF 493
                   :||.||.|   ....||.|     |....||..:|:.::|
Mouse   395 LNIRGELERPNSPISKGHAALQRSVSLGGTYPNISCLSSLKHNCSKG------------------ 441

  Fly   494 HGQRPQQRLLKRVGGGAG--------AGATG-------------GATGSPLVCPPTPTHHARR-- 535
               .|.|.|:|...|..|        ...|.             |....||.  |.||.:.|.
Mouse   442 ---GPSQLLIKFASGNDGKVDSFWRQRDLTNELSDVCKTRDDFLGQVDVPLY--PLPTENPRMER 501

  Fly   536 ---------HARLQAVTANSSLASGGAIPSDPPAVSSQLDYIYL-QDGGQEQGQEQSDEV----V 586
                     |.|     ::.|...|          ..:|...|| ::|.:::..:|::|:    |
Mouse   502 PYTFKDFVLHPR-----SHKSRVKG----------YLRLKMTYLPKNGSEDENADQAEELEPGWV 551

  Fly   587 HI----SSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSGSSGAGAAGEPPLPPAWEARMD 647
            .:    ::|.||..||.|                                    ||||.||.|.|
Mouse   552 VLDQPDAATHLPHPPEPS------------------------------------PLPPGWEERQD 580

  Fly   648 SHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRYQSIRRTITNESRAAQLYNLPTS 712
            ..||.:|::|.:|.|.|:||  :|.......:....|...:|..:.||.|:.:.........|.:
Mouse   581 VLGRTYYVNHESRRTQWKRP--SPDDDLTDEDNDDMQLQAQRAFTTRRQISEDVDGPDNRESPEN 643

  Fly   713 -------ANSNANSTAPAAPP-----------------------PATAIHPAILMLCRPDFYSLL 747
                   .|:..:..|..:||                       |||:         :|    :.
Mouse   644 WEIVREDENTEYSGQAVQSPPSGHIDVQTHLAEEFNTRLAVCGNPATS---------QP----VT 695

  Fly   748 HTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSG 812
            .:|.:     :|..:|:..:            ::....|..|:.|    |..||..||.|.|..|
Mouse   696 SSNHS-----SRGGSLQTCI------------FEEQPTLPVLLPT----SSGLPPGWEEKQDDRG 739

  Fly   813 KQFFIDHQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPA 877
            :.:::||..:.|::..|.:. :.||                            |....|:.....
Mouse   740 RSYYVDHNSKTTTWSKPTMQ-DDPR----------------------------SKIPAHLRGKTD 775

  Fly   878 SSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYED 942
            |:..|  ||||                                                  |:|
Mouse   776 SNDLG--PLPP--------------------------------------------------GWE- 787

  Fly   943 VPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGV-PALERLGHDLQLTILLS 1006
                                   ||  .||..|......||.:.:.. |.|:.:.
Mouse   788 -----------------------ER--THTDGRVFFINHNIKKTQWEDPRLQNVA---------- 817

  Fly  1007 LFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLH 1071
                 |.|            |.:          |:.||::.|...|.|||  |.....|:|.::.
Mouse   818 -----ITG------------PAV----------PYSRDYKRKYEFFRRKL--KKQTDIPNKFEMK 853

  Fly  1072 IRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYS 1136
            :||:::|||::||||...:.||.:.||.:.:|.|:||||||.:||:|||:|:|:|||||||||||
Mouse   854 LRRANILEDSYRRIMGVKRADLLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYS 918

  Fly  1137 ANDTYTVQVSPLSAFVDNCH-DWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLES 1200
            |.|.||:|::|.|...:..| .:|:|.|||.|:|:.|..|||.||.|||||.:|:..:.|.|:||
Mouse   919 ATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLQKLITLHDMES 983

  Fly  1201 LDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIK 1265
            :|:|::.||:||.:||   ..:|.|.|.:.|||.|.....|||.||..|::..||||||:..:|:
Mouse   984 VDSEYYSSLRWILEND---PTELDLRFIIDEELFGQTHQHELKTGGSEIVVTNKNKKEYIYLVIQ 1045

  Fly  1266 WRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQ 1330
            ||....:|:|..:...||:|:|...|:.:||..||||::.|..::|.||||.:|:|::||..|||
Mouse  1046 WRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSMNHQ 1110

  Fly  1331 VIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNALPRAHTCF 1395
            ||.|||:.:....:|:|:||||||||||.:|..||:.|.||.||:.|.:|:||.|:.||||||||
Mouse  1111 VIHWFWKAVWMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPDKLPRAHTCF 1175

  Fly  1396 NRLDLPPYPTPELLYEKLLLAVEETNTF-GIE 1426
            ||||||||.:.:.|::||.:|:|.|..| |::
Mouse  1176 NRLDLPPYESFDELWDKLQMAIENTQGFDGVD 1207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021	38/202 (19%)
		WW	638..667	CDD:459800	14/28 (50%)
		HECW1_helix	738..794	CDD:465766	7/55 (13%)
		HECTc	1068..1424	CDD:238033	179/357 (50%)
Nedd4	NP_001344927.1	C2	<477..530	CDD:472691	12/69 (17%)
		WW	574..602	CDD:238122	13/29 (45%)
		WW	727..756	CDD:459800	10/28 (36%)
		WW	781..813	CDD:197736	14/107 (13%)
		HECTc	874..1203	CDD:214523	169/331 (51%)