DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and hecd-1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001368365.1	Gene:	hecd-1 / 177486	WormBaseID:	WBGene00016405	Length:	2650	Species:	Caenorhabditis elegans

Alignment Length:	1559	Identity:	309/1559 - (19%)
Similarity:	503/1559 - (32%)	Gaps:	456/1559 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 FYEARNG-NESDELEQAFQSALTLTNDVHVSVSEVEEHEPPLASRNQEVAEVEEQQQQLGACALP 126
            |..|:|| |.|.:......|...:..|:...|:|....:||   :....|..........:.|||
Worm  1340 FRIAQNGKNSSGQTHYLSCSGFEIYGDIVDVVTEAICEDPP---KKDSPAGTSSTPGSSSSAALP 1401

  Fly   127 QPSEASLTGSKETREPRHHQTLLSTKSCETPANNATLSPTNSYNGSIGSDGGSSVGGGARRKSWT 191
            ..::..:......||  ::..|.|..|.||..:....|...|......|:..|.|   .|.|.|.
Worm  1402 PLTKEQVLEMLPARE--NNNRLKSGLSLETVTSMLQRSRHRSRGSYKISESKSKV---VRGKDWR 1461

  Fly   192 LSPQSGGSTPLSGAKKKTKTGAPTTTLSNANGDGF------NLWVARECFETVPAEMVDTLSMA- 249
            ...|.||...........::|....|..|.|.:.:      |..:.|   .|.......|.|:|
Worm  1462 WEDQDGGEGKFGRITSPPESGWVDVTWDNGNANSYRFGANGNFDIER---VTSTGHRYSTPSLAS 1523

  Fly   250 EVDEEVDEEEDEEAA--------------------AVESLLGAAAALQASAHVQRRQQQQHHQHL 294
            .|...|.|......|                    :..|..|||:||...|.|:.
Worm  1524 HVPTSVMEAVRRNRAFYTPKTTGGPPSSSVFGTSSSAGSSRGAASALSRFASVKN---------- 1578

  Fly   295 RQPSPPQHRPLERSWPPRAVGRDLKLQGDVFQFDILDTDERLAEEMAQGSG---SSNNSPLATPP 356
               :.|...|........|:|:.     .:...:::|..::.:......:|   |:.:....||.
Worm  1579 ---TTPAGTPSSGGSSGGAIGKK-----SMSTTNLVDERQKTSGPSVASTGQAASAESLQHQTPS 1635

  Fly   357 VRFKPLLKKKIGPDSYINTISTQKVPVHQSYEFPTFPSSSAVGSSSSSPNSLQFPYLRQHRPLTR 421
            :  :.||.:.: |.:: ..|:..:.|..:........|::::.|::|| ||
Worm  1636 L--ENLLARAM-PHAF-GRIAENQEPEDEPMGGEESDSAASMRSAASS-NS-------------- 1681

  Fly   422 ALSNGKASSSEEQ----ASPR-LLLSPKRPRSPPSGCSTRSASPLDISL---------------S 466
            .:|.|.:|..::|    .:|| ...:|..||...:  .|.|.|..|::.               :
Worm  1682 QMSMGSSSQQQQQQDSDMTPRDSAGTPSTPRDDKN--QTLSVSAPDLAAARQRQASAETDGDADA 1744

  Fly   467 PEQHSPTRGRGVGGALQDAVPPGTPTFHGQRP-------------QQRLLKRVGGGAGA--GATG 516
            .|.:|..:..|...|:::. .....|...:..             |::|::.:||..|.  ....
Worm  1745 DETNSEDKTVGADDAMEED-DEEEETMEDEEDDDDDDDDESSNENQEKLVELLGGERGLFDKLKE 1808

  Fly   517 GATGSPLVCPPTPTHHARRHARLQAVTANSSLASGGAIPS------------------------- 556
            ..||..|         :...:..:..|.|.:...||..|.
Worm  1809 VITGESL---------SDASSSAKDATTNEAQKKGGKKPKKWFKKMSSYTDVLKGLMQNRYPVAL 1864

  Fly   557 -DPPAVSSQL-------DYIYLQDGGQEQGQEQSDEV-VHIS----------STRLP-------- 594
             ||.|...::       ||....:.|.:.|....||| .|:.          :.|.|
Worm  1865 LDPAAAGIEMDEMMDDDDYYDFSEDGPDDGDSVEDEVAAHLGMPVDSFASMVAARTPITWRQFSE 1929

  Fly   595 --SIPERSAAAAAAAAAAAAGAALMEPGTGTVSGSSGAGAAGEPPLPPAWEARMDSHGRIFYIDH 657
              |...|..||.|.|.|::.|:...:..|...:..:         |.||::.|   .||    .:
Worm  1930 LMSGSNRERAAMARAVASSRGSPWEDDATVKCTFEA---------LIPAFDPR---PGR----SN 1978

  Fly   658 TTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRYQSIRR---------TITNESRAAQLYNLPTSA 713
            ..:|...:.|......|..........:.|:....:|.         ||.....:|.|:......
Worm  1979 VNQTLEVELPTVVKDFGSTKASSSKIDKDDQMRFFLRGPNMSGVDNVTIEMNDDSASLFRYMQII 2043

  Fly   714 NSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQ 778
            |::.|....:  ..:..|......:|   :.|...||.....|.:..::           .||
Worm  2044 NNSVNWATKS--DRSRRIWEPTYSIC---YCSADQTNVEVSKIPDEESS-----------TPC-- 2090

  Fly   779 RYQYNKDLVALVNTFAQMSRELPSCWET-------KLDQSGKQFFIDHQHRRTSFMDPR-LPVEC 835
              |.|:.| ..:...:::.:.:|....|       ||.....|...|     ...:..| ||..|
Worm  2091 --QVNQCL-ETIGLLSRIQQAMPEAEITPNVFISDKLTLKVTQVLSD-----ALVVAARSLPEWC 2147

  Fly   836 PRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGVPPLPPPRPSSSSSSSRS 900
            .|:|              |.||      ||...... |....::..||
Worm  2148 SRLV--------------YKYP------CLFTVETR-NMYMQATAFGV----------------- 2174

  Fly   901 SHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILR 965
                     :.:.:......|.:...|.|.|.||.::|.                ||       .
Worm  2175 ---------SRTIVWLQQRRDAAVERARGSAQAGNSSAA----------------RQ-------H 2207

  Fly   966 ERQGQHTMSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLN 1030
            :|..::.:.|...|::.:.|.|.                 :|.:|.|
Worm  2208 DRYHEYRVGRLRHERVKVTRAEE-----------------TLLDQAI------------------ 2237

  Fly  1031 SRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQR 1095
             |:.:     |..|.:|.|...|...|  |.|.||           .||  |..:::|   :|||
Worm  2238 -RLMK-----FHADRKAVLEIEYTNEE--GTGLGP-----------TLE--FYALVAA---ELQR 2278

  Fly  1096 GRLAVLW-----DT-------EEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPL 1148
            ..|| ||     ||       |..:|.|...:...:.:.|     ..|||.           :||
Worm  2279 KSLA-LWVCDDDDTHASKSGEEREVDLGEGKKPIGYYVRR-----VGGLFP-----------APL 2326

  Fly  1149 SAFVD---NCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALL--------RLP-----VALSD 1197
            ....|   ...|.||..|..|...|:...|:|...:|||.|.|:        |.|     ::|.|
Worm  2327 PPGTDETKRAADMFRVLGVFLAKVLLDGRLVDLPLSRPFLKLLVHPQIGDDARGPNLHKILSLDD 2391

  Fly  1198 LESLDNEFHQSLQWIR---------DNDIGTGV------------------------DLGLTFCV 1229
            .|.::......|:.:|         :||  |.:                        ||.|.|.|
Worm  2392 FEEVNPVKGSFLKELRALAQRKRLIEND--TSIDSNSKRRKIAELKLHIKGSTCRVEDLALNFTV 2454

  Fly  1230 T-EELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVS 1293
            . ...:....:.||..||.:|.:...|.::|:|:..::.|..|:..|..:...||..|...|.:.
Worm  2455 NPPSKVFQYAEMELVDGGSDIDVTIDNVEQYVEKCEEFYLNTGIAYQMRAFRDGFDRVFPLRTLR 2519

  Fly  1294 VFDARELELVIAG--TAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTG 1356
            .:...|::.:::|  ..|...:|....||.:.||.......:.|..|:|..:.::|...|||.||
Worm  2520 AYSPEEVQRLLSGEQCPEWSRDDILNYTEPKLGYTRESPGFLRFVDVMEALTAQERKNFLQFATG 2584

  Fly  1357 TSSIPYEGFSALRGSTGPRRFCIEK-WGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEE 1419
            .||:|..|.:.|.    ||...:.| .....:.|..:||.:.|.||.|.:..:|.|:||.|:.|
Worm  2585 CSSLPPGGLANLH----PRLTIVRKVESGDGSYPSVNTCVHYLKLPEYSSSAILRERLLTAINE 2644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	7/28 (25%)
		HECTc	1068..1424	CDD:238033	104/417 (25%)
		HECTc	1092..1423	CDD:214523	100/393 (25%)
hecd-1	NP_001368365.1	Ank_2	345..436	CDD:403870
		ANK repeat	345..372	CDD:293786
		ANK repeat	374..403	CDD:293786
		PTZ00322	383..>497	CDD:140343
		ANK repeat	405..436	CDD:293786
		F5_F8_type_C	1243..1365	CDD:419973	7/24 (29%)
		MIB_HERC2	1452..1509	CDD:399589	14/62 (23%)
		HECTc	2221..2648	CDD:238033	121/506 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900