DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and hecw-1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001317872.1	Gene:	hecw-1 / 175438	WormBaseID:	WBGene00009738	Length:	1247	Species:	Caenorhabditis elegans

Alignment Length:	820	Identity:	250/820 - (30%)
Similarity:	397/820 - (48%)	Gaps:	163/820 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   617 MEPGTGTVSGSSGAGAAGEPPLPPA--WEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGRE 679
            :||.|...|.......|.....||.  |:..:|:..|.||::|.|:.|.|.:|....:.......
Worm   581 IEPKTSKKSAPDIMEIASSSQTPPESHWKTYLDAKKRKFYVNHVTKETRWTKPDTLNNNHIEPET 645

  Fly   680 QHHRQQLDR------RYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILML 738
            ..|::..||      .:.:.|||||..|......:|                         |...
Worm   646 PVHKRLSDRSASPRNSFITPRRTITVRSAGCPKSDL-------------------------IQFF 685

  Fly   739 CRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRR--DPPCFQRYQYNKDLVALVNTFAQMSRELP 801
            .|.:|.:.|:.|:.|:.|||..:.::|.:.||::  |||  .:::.....|..||.||.:::.||
Worm   686 QRDEFKTALYENQDAMQIYNECSVVRHAIHRIQKDLDPP--SKFENQPLFVRFVNLFADITQPLP 748

  Fly   802 SCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLS 866
            |.||. :..:.:..|::|.::.|||.|       ||:.|...:.|::..||
Worm   749 SGWEC-ITMNNRTVFLNHANKETSFYD-------PRIRRFETKTSRRGRSV-------------- 791

  Fly   867 ATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMA 931
                                    ||.||::.:....|
Worm   792 ------------------------PSRSSTAHKGKIDH--------------------------- 805

  Fly   932 SAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLG 996
               |..:..||:      :.||....|.|.|             ::.:|:.::...|..|:..|.
Worm   806 ---ALISKCEDL------RKIAQDNFPQIAE-------------RISKKLMLIERFGGLAVASLA 848

  Fly   997 HDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGY 1061
            :||.:|:.||:.:..      .|:.:.:|.                     .::.||..::.:..
Worm   849 NDLDITLALSMLDSN------TEKLAGEGD---------------------NIKMFYEDMKKEKL 886

  Fly  1062 GQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELF 1126
            |:||.:|...:.|..||:||||.|::.:...|::.||.:.::.|..|||||.|||||.|||||||
Worm   887 GKGPSRLCWKVSRDRLLDDAFRIILNVDPFVLKKSRLHIRFEGELALDYGGLSREFFILLSRELF 951

  Fly  1127 NPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRL 1191
            :|..|.|||..|| |.:|:.|.....:....|....||||.||::|:..:|.|||..|||:|.:.
Worm   952 HPKNGYFEYEGND-YHLQLRPRGCETEKEKKWLILCGRVLALAVIHRCYIDVFFTNVFYKSLQKR 1015

  Fly  1192 PVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNK 1256
            ||.|.|.:..|.||::|:.|:.:||:   |||.::|..:..:.|.:.::||.|||::.::.|.||
Worm  1016 PVTLMDFKESDAEFYKSMNWLLENDV---VDLEMSFVYSSMVNGKLAEQELVPGGESQMVTEANK 1077

  Fly  1257 KEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEY 1321
            .|:::.|.:.:..|||::..|.|:..|.::::..|::..::.:|:.:::|:.|:|.||||.||.|
Worm  1078 AEFIDLMCQKKAIRGVEKPLEILLTSFNQILNDNLLNSLESSDLKRILSGSLELDLNDWRTNTIY 1142

  Fly  1322 RSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPN 1386
            :.||.|.|.|:.|||:|||..:|::|..||.||||:||:|:||||||||:....:|||||||...
Worm  1143 KGGYSDCHIVVEWFWEVIETMTNQERFDLLLFVTGSSSVPFEGFSALRGNEEISKFCIEKWGDAT 1207

  Fly  1387 ALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            :.||||||||||.||.|.|.:.|..||..|:....::.||
Worm  1208 SFPRAHTCFNRLQLPSYNTKQQLKSKLQQAIVNGMSYSIE 1247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	11/30 (37%)
		HECTc	1068..1424	CDD:238033	155/355 (44%)
		HECTc	1092..1423	CDD:214523	146/330 (44%)
hecw-1	NP_001317872.1	FBA_2	230..285	CDD:311601
		WW	603..634	CDD:197736	11/30 (37%)
		WW	746..777	CDD:197736	12/38 (32%)
		HECTc	918..1244	CDD:214523	146/329 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157566
Domainoid	1	1.000	94	1.000	Domainoid score	I4712
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1009
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105324
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1661
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.790