DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and Y92H12A.2

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001293292.1	Gene:	Y92H12A.2 / 171719	WormBaseID:	WBGene00022358	Length:	724	Species:	Caenorhabditis elegans

Alignment Length:	855	Identity:	249/855 - (29%)
Similarity:	359/855 - (41%)	Gaps:	263/855 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   590 STRLPSIPERSAAAAAAAAAAAAGAALME----PGTGTVSGSSGAG-----AAGEPPLPPAWEAR 645
            :|:.|:..|.:..:..|:...:.|:..:.    |.:...|.|....     ::|   :|..||.|
Worm   115 TTQAPNPEEYALQSGTASKGKSIGSLFLSFHFMPSSSDNSPSDSTADLQQTSSG---MPQGWEER 176

  Fly   646 MDSHGRIFYIDHTTRTTSWQRPGAAPSGG-PAGREQHHRQQLDRRYQSIRRTITNESRAAQLYNL 709
            .|.:||..|::|..|||.:..|.:..:|. .|..||...::..||..       |....:|:.:.
Worm   177 EDGNGRTVYVNHALRTTQFTPPESVSNGNVDAITEQSVIEETRRRRD-------NYEHRSQVTDE 234

  Fly   710 PTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDP 774
            |:.....:|.        .|||                  ::|..|.:.|...  |:
Worm   235 PSDTTIVSNE--------LTAI------------------DDAMRANFERGGG--HV-------- 263

  Fly   775 PCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVV 839
                  :..:|           ...||..|:.::..:|:.|||||:.:.|::.||| |....||
Worm   264 ------EEEED-----------ELRLPDGWDMQVAPNGRTFFIDHRTKTTTWTDPR-PGAATRV- 309

  Fly   840 RHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHGH 904
                              .|:.|.    |...|.|.||.....|                  |..
Worm   310 ------------------PLLRGK----TDDEIGALPAGWEQRV------------------HAD 334

  Fly   905 G------HNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEI 963
            |      ||...|.                           :|| |...||.:..
Worm   335 GRVFFIDHNRRRTQ---------------------------WED-PRFENENIAG---------- 361

  Fly   964 LRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPV 1028
                                      ||:
Worm   362 --------------------------PAV------------------------------------ 364

  Fly  1029 LNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDL 1093
                       |:.||::.|:.....:|.......|  |..:.:.|..|.||::|.||.....||
Worm   365 -----------PYSRDYKRKVEYLRSRLPKPNSNSG--KCDMVVHRDTLFEDSYRHIMDKKDYDL 416

  Fly  1094 QRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCH-D 1157
             |.:|.:.:..|.||||||.:||:|||||.::||||||||||||.|.||:|::|.|...:..| .
Worm   417 -RNKLWIEFFGETGLDYGGVTREWFFLLSHQIFNPYYGLFEYSATDNYTLQINPHSEACNPEHLS 480

  Fly  1158 WFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVD 1222
            :|.|.||::|:|:.|..||||||.|||||.:|...:.|.|:||:|||::.||.:::|||   ..|
Worm   481 YFHFIGRIIGMAIYHGKLLDAFFIRPFYKMMLGKKITLFDMESVDNEYYNSLIYVKDND---PAD 542

  Fly  1223 LGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVI 1287
            |.|||.:.:.:.|...:.||.|.|.|:.:.|.||:||:|                       .|:
Worm   543 LELTFSLDDSIFGETQNIELIPNGANVPVTEDNKEEYIE-----------------------AVV 584

  Fly  1288 DSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQ 1352
            .|.|:.:|||.||||::.|..:||..||:.||.|:.||..:.||:..||:.|..|.||.|.|:||
Worm   585 PSNLLRLFDANELELLMCGLQKIDVKDWKANTIYKGGYGPSSQVVHNFWKCILSFDNEMRARVLQ 649

  Fly  1353 FVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAV 1417
            ||:|||.:|..||..|.||.|.::|.||:||..:.||||||||||||||||.|.:.|..|||.|:
Worm   650 FVSGTSRVPMNGFRELYGSNGLQKFTIERWGSADMLPRAHTCFNRLDLPPYTTFKELKSKLLTAI 714

  Fly  1418 EETNTF-GIE 1426
            |.:..| |::
Worm   715 ENSEIFSGVD 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	12/28 (43%)
		HECTc	1068..1424	CDD:238033	165/357 (46%)
		HECTc	1092..1423	CDD:214523	157/331 (47%)
Y92H12A.2	NP_001293292.1	C2	20..147	CDD:301316	5/31 (16%)
		WW	170..198	CDD:278809	12/27 (44%)
		WW	272..301	CDD:278809	10/28 (36%)
		WW	323..353	CDD:197736	10/75 (13%)
		HECTc	393..721	CDD:238033	164/354 (46%)
		HECTc	415..720	CDD:214523	157/331 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810