DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and herc-1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_490834.1	Gene:	herc-1 / 171700	WormBaseID:	WBGene00021685	Length:	1019	Species:	Caenorhabditis elegans

Alignment Length:	365	Identity:	114/365 - (31%)
Similarity:	178/365 - (48%)	Gaps:	19/365 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly  1065 PHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPY 1129
            || |:|.:||..::.|...::...::.|||: .|.|....|:..|.||..:|||.|:.|::....
Worm   665 PH-LELTVRREFIVSDTMNQMAGLSESDLQK-PLKVNIAGEDADDAGGVRKEFFILVMRKILQSD 727

  Fly  1130 YGLFEYSANDTYTVQVSPL-SAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPV 1193
            ||:|. ...:::.|..|.| |.|.|  .:.|...||::||::.:..::...|....||.||..|.
Worm   728 YGMFS-EDEESHLVWFSGLPSEFCD--REQFHQLGRLVGLSIYNHSIVPFPFPLALYKYLLDTPP 789

  Fly  1194 ALSDLESLDNEFHQSLQWIRDNDIGTGVDL-GLTFCVTEELLGSVVDRELKPGGKNIIINEKNKK 1257
            .|.||..|.....:.|:.:...:.....|: ||.||::..:||.....||..||....:...|:.
Worm   790 DLEDLCELSPSEGKGLKMLLSYEEDDVEDVFGLNFCISFNILGETHTTELLSGGTEKPVTNANRD 854

  Fly  1258 EYLERMIKWRLERG----VQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLN 1318
            ||:...:..|||.|    :.:|.....:||.|.:.||.:..|...||:.:|.|....|.|::|..
Worm   855 EYVRLYVHHRLELGYNGEIAQQALLFRKGFSESLHSRTLRFFQPCELKEMIVGNENYDWNEFRDI 919

  Fly  1319 TEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWG 1383
            ..||..|..:|..|..||:.....::::|.:.|||:||::.||..|:..|..:..|        .
Worm   920 LMYRGEYSSSHPTIQAFWKAFFALTDDERRKFLQFLTGSTRIPVSGWEELHAAIQP--------S 976

  Fly  1384 KPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTF 1423
            .|.:||.||||||.||||.......|..:|.:::|.|..|
Worm   977 APESLPVAHTCFNLLDLPNIADDVELLRRLRISIEHTEGF 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809
		HECTc	1068..1424	CDD:238033	112/362 (31%)
		HECTc	1092..1423	CDD:214523	106/336 (32%)
herc-1	NP_490834.1	ATS1	2..359	CDD:227511
herc-1	NP_490834.1	HECTc	667..1016	CDD:238033	111/360 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810