DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hecw and wwp-1

DIOPT Version :10

Sequence 1:NP_572574.2 Gene:Hecw / 31905 FlyBaseID:FBgn0261931 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_740775.1 Gene:wwp-1 / 171647 WormBaseID:WBGene00007009 Length:794 Species:Caenorhabditis elegans


Alignment Length:907 Identity:276/907 - (30%)
Similarity:378/907 - (41%) Gaps:280/907 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   534 RRHARLQAVTANSSLASGGAIPSDPPAVSSQLDYIYLQDGGQEQGQEQSDEVVHISSTRLPSIPE 598
            ||.|.::|.||.|  ||..|..|:..|.|                          ||.|.|:..:
 Worm   154 RRSAGVRAETAAS--ASSEASTSNGVATS--------------------------SSARRPATAK 190

  Fly   599 RSAAAAAAAAAAAAGAALMEPGTGTVSGSSGAGAAGEPPLPPAWEARMDSHGRIFYIDHTTRTTS 663
            |...||..:.||||.||       |..|:..|||  |..||..||.|.|.:||.:|:||||::|:
 Worm   191 RDTLAAPTSTAAAAAAA-------TAGGTPAAGA--EEQLPDGWEMRFDQYGRKYYVDHTTKSTT 246

  Fly   664 WQRPGAAPSGGPAGREQHHRQQLDRRYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPA 728
            |:||...|.  |.|.|. .|....|.|.....|.|.      .:..||:....|:....:....|
 Worm   247 WERPSTQPL--PQGWEM-RRDPRGRVYYVDHNTRTT------TWQRPTADMLEAHEQWQSGRDQA 302

  Fly   729 TAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAALKHMV--MRIRRDPPCFQRYQYNKDLVALVN 791
                    ||.....:.|...|      ::.:..|..:.  ...|:||...:.|..|.     ||
 Worm   303 --------MLQWEQRFLLQQNN------FSADDPLGPLPEGWEKRQDPNTSRMYFVNH-----VN 348

  Fly   792 T-----------FAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVVRHRQQH 845
            .           |....:.||..||.:..:.|..||||||.:.|::.|||               
 Worm   349 RTTQWEDPRTQGFRGSDQPLPDGWEMRFTEQGVPFFIDHQSKTTTYNDPR--------------- 398

  Fly   846 SQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNT 910
                                               :|.|..|                       
 Worm   399 -----------------------------------TGKPVGP----------------------- 405

  Fly   911 TSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSR 975
                          .|..|:                                       |..|.:
 Worm   406 --------------LGVVGV---------------------------------------QMAMEK 417

  Fly   976 QLREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPP 1040
            ..|.||...|.                :.||                       ||         
 Worm   418 SFRWKIAQFRY----------------LCLS-----------------------NS--------- 434

  Fly  1041 FRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTE 1105
                                   .|:.:|:.:.|:::.||:|:.||..|..||:| ||.:.:..|
 Worm   435 -----------------------VPNHVKITVSRNNVFEDSFQEIMRKNAVDLRR-RLYIQFRGE 475

  Fly  1106 EGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCH-DWFRFSGRVLGLA 1169
            |||||||.:||:|||||.|:.||.|.||.|:.|:.|::|::|.| ||:..| .:|.:.||.:.:|
 Worm   476 EGLDYGGVAREWFFLLSHEVLNPMYCLFMYAGNNNYSLQINPAS-FVNPDHLKYFEYIGRFIAMA 539

  Fly  1170 LVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELL 1234
            |.|...:.:.||.||||.:|...:.|.|:|.:|:|.:.||.||:||:|.. .|:.|.|....|||
 Worm   540 LFHGKFIYSGFTMPFYKKMLNKKIVLKDIEQVDSEIYNSLMWIKDNNIDE-CDMELYFVADYELL 603

  Fly  1235 GSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARE 1299
            |.:...|||.||..|.:.|:||.||:|.:::||..|||::||::...||..|.....:..||.||
 Worm   604 GELKTYELKEGGTEIAVTEENKLEYIELLVEWRFNRGVEQQTKAFFTGFNSVFPLEWMQYFDERE 668

  Fly  1300 LELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEG 1364
            |||::.|..::|.:||:.||.||. |....:.:.||||.:.....|:|.|||||||||..:|..|
 Worm   669 LELLLCGMQDVDVDDWQRNTVYRH-YAPQSKQVTWFWQWVRSLDQEKRARLLQFVTGTCRVPVGG 732

  Fly  1365 FSALRGSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            ||.|.|||||:.||||:.||.|.|||:||||||||||||.:.:.|.|||.:|:|.|..||.|
 Worm   733 FSELMGSTGPQLFCIERVGKENWLPRSHTCFNRLDLPPYRSYDQLVEKLSMAIEMTEGFGNE 794

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HecwNP_572574.2 PHA03247 <411..562 CDD:223021 12/27 (44%)
WW 638..667 CDD:459800 15/28 (54%)
HECW1_helix 738..794 CDD:465766 11/68 (16%)
HECTc 1068..1424 CDD:238033 167/356 (47%)
wwp-1NP_740775.1 C2 29..147 CDD:472691
WW 221..250 CDD:459800 15/28 (54%)
HUL4 <251..794 CDD:227354 226/771 (29%)
Blue background indicates that the domain is not in the aligned region.

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