Protein Alignment CG42797 and PLEKHA7

DIOPT Version :9

• Sequence 1: NP_572574.2
• Gene: CG42797 / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_024304124.1
• Gene: PLEKHA7 / 144100
• HGNCID: 27049
• Length: 1365
• Species: Homo sapiens
• Alignment Length: 662
• Identity: 131/662 - (19%)
• Similarity: 186/662 - (28%)
• Gaps: 237/662 - (35%)

  Fly   412 YLRQHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSP----------PSGCSTRSASPLDI--- 463
            |..|..||.......||.|               |.||          |:|...:.|.|...
Human   345 YRSQRDPLEGKRDRSKARS---------------PYSPAEEDALFMDLPTGPRGQQAQPQRAEKN 394

  Fly   464 SLSPEQHSPTRGRGVGGALQDAVPPGT-PTFHGQR---------------------PQQRLLKRV 506
            .:.|..:.|....|.|| .|.|.||.| |..|.||                     |..:.|.|.
Human   395 GMLPASYGPGEQNGTGG-YQRAFPPRTNPEKHSQRKSNLAQVEHWARAQKGDSRSLPLDQTLPRQ 458

  Fly   507 GGGAGAGATGGATGSPLVCP------PTPTHHARRHARLQAVTANSSLASGGAIPSDPPAVSSQL 565
            |           .|..|..|      |..|.|                .|||   |.||..:...
Human   459 G-----------PGQSLSFPENYQTLPKSTRH----------------PSGG---SSPPPRNLPS 493

  Fly   566 DYIYLQDGGQEQGQEQSDEVVHISST--RLPSIPERSAAAAAAAAA------------AAAGAAL 616
            ||.|.||..........:...|...|  :|....:|......:..|            ..:.:.|
Human   494 DYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPICLGSPEFTDQGRSRSML 558

  Fly   617 MEPGTGTVSGS-SGAGAAGEP-------PLPPAWEARMDSHGRIFYID------------HTTRT 661
            ..|.:.:|..| |.....|.|       |..||....:....:...:|            |..:.
Human   559 EVPRSISVPPSPSDIPPPGPPRVFPPRRPHTPAERVTVKPPDQRRSVDISLGDSPRRARGHAVKN 623

  Fly   662 TSWQRPGAAPSGG----PAGREQHHRQQLDRRYQSIRRTITNESRAAQLYNLPTSANSNANSTAP 722
            :|.....:.||.|    .......|.:.|:.....:.|...::::.|.:.|...|.......|.|
Human   624 SSHVDRRSMPSMGYMTHTVSAPSLHGKSLEELSLLLTRLRRHQAKLASVRNFAISQLLQHQLTFP 688

  Fly   723 AAPPPATAI----------------HPAILML----------CRP----DFYSLL---------- 747
            ......|.:                .|.|.:|          |||    ....||
Human   689 TCQADDTYLQLKKDLEYLDLKIKNNEPLINVLYKVLKKSARGCRPRRSMTGRDLLKDRSLKPVKI 753

  Fly   748 --HTNEAALAIY-----------NRNAALK-------------HMVMRIRRDPP------CFQRY 780
              ...:..|:|:           ::..|||             |..|...||.|      .:|:.
Human   754 AESDTDVKLSIFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQK 818

  Fly   781 QYNKDLVALVNTFAQMSRELPSCWE--TKLDQSGKQF--FIDHQHRRTSFMDPRLPVECPRVVRH 841
            ...:|||.:....::.|.|:.:.|.  .||:...:|.  .:..||||..|.
Human   819 LLQEDLVHIRAELSRESTEMENAWNEYLKLENDVEQLKQTLQEQHRRAFFF-------------- 869

  Fly   842 RQQHSQQQSSVGYYYPDLVDGNCLSATSGHINA------------------SPASSVSGVPPLPP 888
             |:.||.|..: :...|:..|  |||...:...                  .|..|:|.....||
Human   870 -QEKSQIQKDL-WRIEDVTAG--LSANKENFRILVESVKNPERKTVPLFPHPPVPSLSTSESKPP 930

  Fly   889 PRPSSSSSSSRS 900
            |:||..:|..|:
Human   931 PQPSPPTSPVRT 942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	5/40 (13%)
		HECTc	1068..1424	CDD:238033
		HECTc	1092..1423	CDD:214523
PLEKHA7	XP_024304124.1	WW	11..40	CDD:306827
		WW	56..85	CDD:306827
		PH_PEPP1_2_3	159..281	CDD:270068
		NESP55	<299..460	CDD:115071	32/141 (23%)
		DUF1640	779..905	CDD:311647	32/143 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900