Protein Alignment Hecw and Hecw

DIOPT Version :10

• Sequence 1: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_061498351.1
• Gene: Hecw / 1272391
• VectorBaseID: AGAMI1_002409
• Length: 1286
• Species: Anopheles gambiae
• Alignment Length: 1549
• Identity: 686/1549 - (44%)
• Similarity: 827/1549 - (53%)
• Gaps: 397/1549 - (25%)

  Fly     2 EPPAA-PVP-LQPLAASSACLAD-RSPVDPIAVRLQQEEQAEGDDEEEEEEEEDDDDDPKEEEAF 63
            ||.|| |.| ..|........|| .|..|.:|:. .|..|::|:||::::||:|::||.:|||
Mosquito    11 EPEAACPRPTANPPGKEPEPEADPESEQDGLAIG-GQSHQSDGEDEDDDDEEDDEEDDEEEEE-- 72

  Fly    64 YEARNGNESDELEQAFQSALTLTN-----DVHVSVSEVE---EHEPPLASRNQEVAEVEEQ---- 116
                ...|..||..|.|.....|.     |:.:.....|   |.:.|...|::|..|.||:
Mosquito    73 ----EEEEPPELRVAVQQDFPPTPYEECLDLKMFELRTEPAGEAQEPTPERSEEDEEGEEEGSGE 133

  Fly   117 --------------QQQLGACALPQPSEASLTGSKETREPRHHQTLLSTKSCETPANNATLSPTN 167
                          |.:.|...:|.||..||..:          |....:..|.|||.|...|
Mosquito   134 VEADSVDNSAEDNLQPEPGPAIVPSPSATSLPAA----------TSGVRRKSEQPANGAPEPP-- 186

  Fly   168 SYNGSIGSDGGSSVGGGARR-KSWTLSPQSGGSTPLSGAKKKTKTGAPTTTLSNANGDGFNLWVA 231
                .:..|...:..|..:: :...|||:..|.     ::||                  ..|
Mosquito   187 ----DVVPDEEPTPNGTKKKVRPNRLSPERAGC-----SRKK------------------QFW-- 222

  Fly   232 RECFETVPAEMVDTLSMAEVDEEVDEEEDEEAAAVESLLGAAAALQASAHVQRRQQQQHHQHLRQ 296
                                              :|...|...
Mosquito   223 ----------------------------------IEGTAGTGG---------------------- 231

  Fly   297 PSPPQHRPLERSWPPRA----VGRDL---KLQGDVFQFDILDTDERLAEEMAQGSGSSNNSPLAT 354
                 ||||||||||:|    .||..   ...||.|.|||:|.||:..::..|.
Mosquito   232 -----HRPLERSWPPKAHRPSPGRPFPGATTPGDGFSFDIIDMDEQQQQQQQQH----------- 280

  Fly   355 PPVRFKPLLKKKIG----PDSYINTISTQKVPVHQSY--------EFPTFPSSSA---------- 397
               |....::..:|    ||:..|.:..|..|..::.        |..|..|:.|
Mosquito   281 ---RHHEEVEGAVGGQEMPDAEGNPVGGQSTPRRRNRRPDRNGNDEPDTGESARATGAGKQPLRK 342

  Fly   398 -VGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSPPSGCSTRSASPL 461
             ||.|.:..:.:. ..:|.||||.|..|||:.....|       ..|.||            .|:
Mosquito   343 MVGRSGADEHEVA-GAVRPHRPLARTPSNGREPRCRE-------YGPIRP------------LPV 387

  Fly   462 DISLSPEQHSPTRGRGVGGALQDAVPPGTPTFHGQR----------PQQRLLKRVGGGAGAGATG 516
            |.:.....|:         |...|..||||   |.|          ||.|.|.|||        |
Mosquito   388 DYTADASVHT---------ARSPASEPGTP---GDRSPDQPQGRSAPQPRQLTRVG--------G 432

  Fly   517 GATGSPLVCPPTPTHHARRHARLQAVTA----------NSSLASGGAIPSDPPAVSSQLDYIYLQ 571
            |..||.|||||||||||||:....|.:|          ...|......|..||
Mosquito   433 GRAGSELVCPPTPTHHARRNRAGPAPSAAPPEHGFGPPELRLHRQQTAPDQPP------------ 485

  Fly   572 DGG---QEQGQEQSDE---VVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSGSSGA 630
            :||   ||....:..|   |.|:.|.||||||||:.            |.|.||
Mosquito   486 EGGFGEQEPPPGEPAEGATVRHVPSMRLPSIPERTR------------AILAEP----------- 527

  Fly   631 GAAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGRE-----QHHRQQLDRRY 690
                :.|||||||||||||||||||||.|||||||||      ||.|..     ..|||||||||
Mosquito   528 ----DEPLPPAWEARMDSHGRIFYIDHATRTTSWQRP------GPLGTSAVLLPDPHRQQLDRRY 582

  Fly   691 QSIRRTITN----ESRAAQLYNL--PTSANSNANST---APAAPPPATAIHPAILMLCRPDFYSL 746
            .||||||..    |:.||...:.  |.:..|.::||   ..|.|..|.:.|||:|||||.||||:
Mosquito   583 ASIRRTIYEHLRPENGAAPSTSSTGPVATRSRSSSTGRSTVALPSTAGSFHPALLMLCRSDFYSM 647

  Fly   747 LHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQS 811
            ||||..|:.:|||||||||||.|:||||.||.|||:|:|||||||.|||.::||||.||||||||
Mosquito   648 LHTNGDAIQLYNRNAALKHMVSRVRRDPGCFGRYQHNRDLVALVNCFAQPAQELPSGWETKLDQS 712

  Fly   812 GKQFFIDHQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASP 876
            ||||||||.:|||||:|||||.|.||...||       ..||               ...:...|
Mosquito   713 GKQFFIDHVNRRTSFIDPRLPTEGPRARHHR-------PPVG---------------PAALLLPP 755

  Fly   877 ASSVSGVP-----PLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGAT 936
            ||.    |     |:|||||  ..:.||.:|
Mosquito   756 ASG----PFPDERPIPPPRP--PGTLSRLAH---------------------------------- 780

  Fly   937 AAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQL 1001
             ....::|:|||:||:|||||||||||||||.|....||.||||||.:||||..||:|..|||:|
Mosquito   781 -VSSPEIPVAYNDKVVAFLRQPNILEILRERHGAAACSRNLREKINAIRVEGTTALDRYSHDLEL 844

  Fly  1002 TILLSLFEQEIMGFVPIEERSPQ-----------------GSPVLNSRMPQRAPPPFRRDFEAKL 1049
            ||||||||.|:|.:||...|||.                 |:.....|..|||  |.||||||||
Mosquito   845 TILLSLFEDEVMTYVPPRARSPPEPGTSAGYGPCGGLVPGGALKPGGRHVQRA--PMRRDFEAKL 907

  Fly  1050 RSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPS 1114
            |:|||||||||||||||||:|.:||:||:||||.|||:|:::||||.||.::||||:||||||||
Mosquito   908 RTFYRKLESKGYGQGPHKLRLEVRRAHLVEDAFERIMAASRRDLQRCRLNIVWDTEDGLDYGGPS 972

  Fly  1115 REFFFLLSRELFNPYYGLFEYSANDTYTVQVSP-LSAFVDNCHDWFRFSGRVLGLALVHQYLLDA 1178
            ||||:||||:||:||..:|||||||.||||::| .....|:..:|:||:||||||||||||||||
Mosquito   973 REFFYLLSRQLFSPYRNMFEYSANDIYTVQIAPERPTDRDDILEWYRFAGRVLGLALVHQYLLDA 1037

  Fly  1179 FFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELL-GSVVDREL 1242
            |||||||||||||||:||||||||:.|||||.|||||::....:|||.|.||||.. |:.:|.||
Mosquito  1038 FFTRPFYKALLRLPVSLSDLESLDSSFHQSLLWIRDNNMDNCGELGLNFTVTEERSDGTSIDIEL 1102

  Fly  1243 KPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGT 1307
            ||.|:||.::|:||::||:|:|||||||||.||||.|||||.||:|.|||:||||.||||||:||
Mosquito  1103 KPNGRNITVSERNKRDYLDRIIKWRLERGVLEQTEWLVRGFNEVVDHRLVAVFDASELELVISGT 1167

  Fly  1308 AEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGST 1372
            .|||.:|||.|||||.||||.|.||:|||.||||.|||||||||||||||||||::||:.||||.
Mosquito  1168 VEIDVHDWRANTEYRGGYHDTHHVIMWFWAVIERMSNEQRLRLLQFVTGTSSIPHDGFAGLRGSN 1232

  Fly  1373 GPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            |.||||||||||.|||||:|||||||||||||||::|||||:||||||||||||
Mosquito  1233 GLRRFCIEKWGKANALPRSHTCFNRLDLPPYPTPDVLYEKLVLAVEETNTFGIE 1286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021	54/170 (32%)
		WW	638..667	CDD:459800	27/28 (96%)
		HECW1_helix	738..794	CDD:465766	41/55 (75%)
		HECTc	1068..1424	CDD:238033	262/357 (73%)
Hecw	XP_061498351.1	None