Protein Alignment Hecw and Smurf

DIOPT Version :10

• Sequence 1: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_061510268.1
• Gene: Smurf / 1270684
• VectorBaseID: AGAMI1_012422
• Length: 1244
• Species: Anopheles gambiae
• Alignment Length: 1289
• Identity: 366/1289 - (28%)
• Similarity: 532/1289 - (41%)
• Gaps: 313/1289 - (24%)

  Fly   252 DEEVDEEEDEEAAAVESLLGAAAALQASAHVQRRQQQQHHQHLRQPSPPQHRPLERSWPPRAVGR 316
            |..|.|::|   ||.||::           |::.||||.    :||.|||...|.|.|
Mosquito   155 DVRVPEDDD---AADESMI-----------VEQPQQQQQ----QQPPPPQQHQLPRGW------- 194

  Fly   317 DLKLQGDVFQFDILDTDERLAEEMAQGSGSSNNSPLATPPVRFKPLLKKKIGPDSYIN--TISTQ 379
                            :||.|:.                            |...|:|  |.:||
Mosquito   195 ----------------EERSAQN----------------------------GRTYYVNHYTKTTQ 215

  Fly   380 KVPVHQSYEFPTFPSSSAV-------GSSSSSP-------NSLQFPYLRQHRPLTRALSNGKASS 430
                   :..||.|:...|       .::||:|       |....|:.:|...:..:.::.....
Mosquito   216 -------WSRPTEPAGPPVRQSGNNNAANSSTPLTANGNVNGGGVPHPQQQHHILGSPTSAANGV 273

  Fly   431 SEEQASPRLLLSPKRP---------RSPPSGCSTRSASPLDISLSPE----QHSPTRGRGVGGAL 482
            .||...|.:...|.:.         :|..||....||..|..|.:.|    ||
Mosquito   274 GEESGCPTIPAGPSKSATNHSINSIQSNDSGSRRHSAEILVSSNNKENCIQQH------------ 326

  Fly   483 QDAVPPGTPTFHGQRPQQRLLKRV-GGGAG----AGATGGATGSPLVCPPTPTHHARRH-----A 537
                 |.:...|....:||..|.| .||.|    .|..||..|.      ||.|:..|:     .
Mosquito   327 -----PSSQQQHHNGKEQRTGKDVENGGRGDALVNGNAGGGGGG------TPAHNRHRNEAKSPV 380

  Fly   538 RLQ----AVTANSS----LASGGAIPSDPPAVSSQLDYIYLQDGGQEQGQEQSDEVVHISSTRLP 594
            |:|    .:|.:||    |:...:..:.|.....|.|.......|..:.|:.|.....|.:..:.
Mosquito   381 RIQDESLLITPSSSNTSPLSEINSPITSPKQQQQQQDVSPRSGNGGREPQQVSGMTNAIGTLSID 445

  Fly   595 SIPERSAAAAAAAAAAAAGAALM---EPGTGTVSGSS-------GAGAAGEP--------PLPPA 641
            :.|.||...|.:.........::   ..|.|..:.||       ..|.||:|        |..|:
Mosquito   446 APPARSGTNATSGGGGGGQQCVVMVNGSGAGVTNYSSPNHQHQRSTGDAGQPAGHPAAAKPTVPS 510

  Fly   642 WEARMDSHGRIFYIDHTT-------------RTTSWQRP--------GAAPSGGPAGREQH---- 681
            :.....|:|.......||             .::|...|        |....||..||.||
Mosquito   511 YLPLSTSNGTTNGTAGTTGSSNSSPHNGVSNHSSSASAPDTVGGGGGGGGGGGGGGGRSQHHHGT 575

  Fly   682 ---------HRQQLDRRYQSIR--RTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAI 735
                     ||:....||...|  |......|.....:.|........|.||  ||.|   .||:
Mosquito   576 PTTGGESGGHREGSASRYHRTRSGRHAEEPGRRRTSRDRPPRPLMGGGSMAP--PPNA---RPAL 635

  Fly   736 LMLCRPDF-----YSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQ 795
            :...||..     |.:..|.:..:..|  :...|.......|.|..|...          |...:
Mosquito   636 VPFIRPAVDLPHGYEIRTTQQGQVYFY--HIPTKQSTWHDPRIPRDFDTQ----------NLTTE 688

  Fly   796 MSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLV 860
            ....||..||.:...||:.:|:||.:|.|.|.|||:.:...:::|.:...:...::|.
Mosquito   689 TLGPLPHGWEQRKTASGRVYFVDHNNRTTQFTDPRINMHILQMIRRQNSVAAAAAAVA------- 746

  Fly   861 DGNCLSATSG---HINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADR 922
                 :||.|   ..|...:|.:||..|..|....::.|.|
Mosquito   747 -----AATGGGGVATNGCSSSPLSGAGPQVPNGTGAAGSGS------------------------ 782

  Fly   923 SAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVE 987
            |.|.||.:|.|..        |||                     .|..:..|..|..:.|..:.
Mosquito   783 SRYAAAALAEAVN--------PIA---------------------NGVSSPWRACRCVVCIDMLH 818

  Fly   988 GVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSF 1052
            |    .|.|..:..|...:.....:...:|   ..|||  :::|   ....|.:|.|...|:|:.
Mosquito   819 G----PRGGSAIAATGSSTTTTNHVTNNIP---DLPQG--LMDS---ADLLPKYRSDLVGKIRAL 871

  Fly  1053 YRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREF 1117
            .::|:.. ..|..| .:|.:.|:.:.|:::|.||....||: |.||.|.:..||||||||.:||:
Mosquito   872 RQELQLL-QPQSGH-CRLEVSRNEIFEESYRLIMKMRPKDM-RKRLMVKFKGEEGLDYGGVAREW 933

  Fly  1118 FFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTR 1182
            .:|||.|:.||.||||:||.:|.|::|::|.|:.......:|.|.||:||:|:.|.::||..||.
Mosquito   934 LYLLSHEMLNPQYGLFQYSRDDHYSLQINPDSSINPEHLSYFHFVGRILGIAVFHNHVLDGGFTL 998

  Fly  1183 PFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGK 1247
            ||||.||..|:.|||:|.:|.:.|:||.||.:|:| ||: :..||.|.....|.:...||||.|.
Mosquito   999 PFYKQLLNKPITLSDIEDVDPDLHRSLTWILENNI-TGI-IDSTFSVENNSFGVLKVHELKPNGA 1061

  Fly  1248 NIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDT 1312
            :|.:.|.||:||::..:.:|..||:::|..:|.:||.|:|.|.|:..||.|||||:|:|.::||.
Mosquito  1062 SIAVTEDNKREYVKLYVNYRFMRGIEQQFLALSKGFGELILSHLLRPFDERELELLISGISKIDV 1126

  Fly  1313 NDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGST---GP 1374
            |||:.||..:....|..| ||||||::|.:|.|.|.:|||||||:..:|.:||.||:|||   ||
Mosquito  1127 NDWKANTRLKQCTADTPQ-IVWFWQIVESYSPEMRAQLLQFVTGSCRVPLQGFRALQGSTGAVGP 1190

  Fly  1375 RRFCIEKWGKP--NALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            |.|.|......  ..||:|||||||||||.|.:.:|:|:||..|||||..|.:|
Mosquito  1191 RLFTIHLTADVPLQNLPKAHTCFNRLDLPMYDSYQLMYDKLTQAVEETCGFAVE 1244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021	40/181 (22%)
		WW	638..667	CDD:459800	6/41 (15%)
		HECW1_helix	738..794	CDD:465766	10/60 (17%)
		HECTc	1068..1424	CDD:238033	169/360 (47%)
Smurf	XP_061510268.1	None