DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and Ube3b

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_473434.2	Gene:	Ube3b / 117146	MGIID:	1891295	Length:	1070	Species:	Mus musculus

Alignment Length:	393	Identity:	126/393 - (32%)
Similarity:	197/393 - (50%)	Gaps:	39/393 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly  1065 PHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAV-----LWDTEEGLDYGGPSREFFFLLSRE 1124
            ||...:.||||.:|||.:.::...::..: :|.:.|     |...|.|:|..|..:||...:.:.
Mouse   680 PHVTHITIRRSRMLEDGYEQLRQLSQHAM-KGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKR 743

  Fly  1125 LFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALL 1189
            :|:|...||:.::.|. .:..||.|...:|....|.|.|::||.|:....::|..|...|...:|
Mouse   744 VFDPALNLFKTTSGDE-RLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQML 807

  Fly  1190 R-----LPVALSDLESLDNEFHQSLQWIR--DNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGK 1247
            .     ...::.:|.|||:||:::|..|:  |.||   .|||||....|:::|.:|..||.||||
Mouse   808 GHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI---ADLGLTLSYDEDVMGQLVCHELVPGGK 869

  Fly  1248 NIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAG-TAEID 1311
            .|.:.::||..|:..|..:|:...::.||.:|:.||..:|....:.:|...||:.:|:| .||||
Mouse   870 TIPVTDENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEID 934

  Fly  1312 TNDWRLNTEYRSGYHDNHQVIVWFWQVI-ERFSNEQRLRLLQFVTGTSSIPYEGFSALR------ 1369
            ..|.:.:|.|..|:|.:|:||:|.|.:: ..|:.|:|...|:|||..|..|..||:.|:
Mouse   935 LEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPEERAMFLKFVTSCSRPPLLGFAYLKPPFSIR 999

  Fly  1370 --------------GSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEET 1420
                          ||.....|.|.|......||.:.||||.|.||.|....:|.|||..|:...
Mouse  1000 CVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMN 1064

  Fly  1421 NTF 1423
            ..|
Mouse  1065 TGF 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809
		HECTc	1068..1424	CDD:238033	124/390 (32%)
		HECTc	1092..1423	CDD:214523	116/364 (32%)
Ube3b	NP_473434.2	HECTc	684..1068	CDD:238033	124/389 (32%)
Ube3b	NP_473434.2	HECTc	709..1067	CDD:214523	116/361 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810