DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and Magi2

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_446073.2	Gene:	Magi2 / 113970	RGDID:	621855	Length:	1277	Species:	Rattus norvegicus

Alignment Length:	781	Identity:	159/781 - (20%)
Similarity:	241/781 - (30%)	Gaps:	300/781 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   442 SPKRPRSPPSGCSTRSASPLDISLSPEQHSPTRGRGVGGALQDAVPPG-TPTFHGQR-------- 497
            :||.|..|         :||.::::                 |.:.|| ||:..|:|
  Rat   185 TPKPPAEP---------APLLLNVT-----------------DQILPGATPSAEGKRKRNKSVTN 223

  Fly   498 --------PQQRLLKR-VGGGAGAGATGGATGSPLVCPPTPTHHARRHARLQAVTANSSLASGGA 553
                    |::...:| |..|.|           :|..|..:.|           .:.|..:.|.
  Rat   224 MEKASIEPPEEEEEERPVVNGNG-----------VVITPESSEH-----------EDKSAGASGE 266

  Fly   554 IPSDP-PAVSSQLDYIYLQDGGQEQGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALM 617
            .||.| ||.      :|      .|.:|..|::....||:    ||.:
  Rat   267 TPSQPYPAP------VY------SQPEELKDQMDDTKSTK----PEEN----------------- 298

  Fly   618 EPGTGTVSGSSGAGAAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHH 682
                           ....|||..||......|.:::|||.|:||||..|..|....||  |:..
  Rat   299 ---------------EDSDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPA--EECK 346

  Fly   683 RQQLDRRYQSI--------------RRT-----ITNESRAAQLYNLPTSANSNANSTAPAAPPPA 728
            ..:|...::.|              |||     :....|..|.:|:|.:........||....
  Rat   347 ENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFRE-- 409

  Fly   729 TAIHPAILMLCRPDFYSLLHTNEAA-LAIYNRNAALKH-------------------MVMRIRRD 773
                       :|     |.|.:|: |.....:..||.                   .|..:..|
  Rat   410 -----------KP-----LFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPD 458

  Fly   774 PPCFQRYQ--------YNKDLVALVNTFAQMSRELPSCWETKLDQS-------GKQFFIDHQHRR 823
            .|..|..:        |..::..|.:|.|.:.:...|   ..:.||       |.....|.:...
  Rat   459 GPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQS---VPIGQSVNLVLCRGYPLPFDPEDPA 520

  Fly   824 TSFMDPRLPVECPRVVRHRQQHSQQQ-----SSVGYYYPDLVDGNCLSATSGHINASPASSVSGV 883
            .|.:.|...:|.|..|....:|:.:.     |......||:.|             .|..|:..:
  Rat   521 NSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVPDITD-------------RPPHSLHSM 572

  Fly   884 P-------PLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAY----GAAGMASAGATA 937
            |       ..|||               .|:.|.:.|.|.|..|:....    ||.|.   |.|.
  Rat   573 PADGQLDGTYPPP---------------VHDDNVSVASSGATQAELMTLTIVKGAQGF---GFTI 619

  Fly   938 AGYEDVPIAYNEKVIAFLRQ-PNILE--ILRERQGQHTMSRQLREKINILRVEGVPALERLGHDL 999
            |   |.|.....|.|..::. |.:.|  ::.|...|:..:....|.::||:  ..|    :|.:.
  Rat   620 A---DSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILK--DCP----VGSET 675

  Fly  1000 QLTILLSLFEQEIMGFVPIEERSP-------QGSPVLN---SRMPQRAP-PP--FRRDFEAKLRS 1051
            .|.|....|      |.|.:...|       ||||..:   ..:||..| ||  .|..|.....:
  Rat   676 SLIIHRGGF------FSPWKTPKPMVDRWENQGSPQTSLSAPAVPQSLPFPPALHRSSFPDSTEA 734

  Fly  1052 F----------YRK----LESKGY----------GQGP--HKLKLHIRRSHLLEDAFR-RIMSAN 1089
            |          |.|    .||:..          ..||  .:|.:|:||   :|..|. ||:..:
  Rat   735 FDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRR---MESGFGFRILGGD 796

  Fly  1090 K 1090
            :
  Rat   797 E 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	13/28 (46%)
		HECTc	1068..1424	CDD:238033	8/24 (33%)
		HECTc	1092..1423	CDD:214523
Magi2	NP_446073.2	PDZ_signaling	22..96	CDD:238492
		GuKc	118..291	CDD:214504	32/165 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..308		32/172 (19%)
		Interaction with DDN. /evidence=ECO:0000250	302..381		24/80 (30%)
		WW	304..333	CDD:395320	13/28 (46%)
		WW	350..381	CDD:197736	5/30 (17%)
		PDZ	428..509	CDD:214570	13/83 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..575		6/31 (19%)
		PDZ	602..683	CDD:214570	21/92 (23%)
		MAGI_u5	687..758	CDD:406953	18/70 (26%)
		PDZ	775..861	CDD:214570	8/26 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..913
		PDZ_signaling	920..1007	CDD:238492
		PRK10263	<1007..>1135	CDD:236669
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1011..1130
		PDZ_signaling	1140..1220	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900