DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and Plekha5

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_006506926.1	Gene:	Plekha5 / 109135	MGIID:	1923802	Length:	1270	Species:	Mus musculus

Alignment Length:	987	Identity:	175/987 - (17%)
Similarity:	281/987 - (28%)	Gaps:	375/987 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 TLLSTKSCETPANNATLSPTNSYNGSIGSDGGSSVGGGARRKSWTLSPQSGGSTPLSGAKK---- 207
            |:.|....|.|.  :.::..::||  :.||             :.:.|.|........:||
Mouse   109 TMTSEDKKERPI--SMINEASNYN--MASD-------------YAVHPMSPVGRTSRASKKVHNF 156

  Fly   208 -------KTKTGAPTTT---LSNANGDGFNLWVARECFETVPAEMVDTLSMAEVDEEVDEEEDEE 262
                   |....||...   |...:..|..||..|..          .||...:....||:|
Mouse   157 GKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWF----------VLSDLCLFYYRDEKE--- 208

  Fly   263 AAAVESLLGA-------AAALQASAHVQRRQQ-QQHHQHLR--------------------QPSP 299
                |.:||:       .|.|.|..|:.|:.. :..|.::|                    ..:.
Mouse   209 ----EGILGSILLPSFQIAMLTAEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAAL 269

  Fly   300 PQHRPLERSWPPRAVGRDLKLQGDVFQF--DILDTDERLAEEMAQGSGSSNNSP----LATPPV- 357
            .|..|::|.               .|.|  |.:.||....:|       :||.|    |..|.|
Mouse   270 VQTEPVKRI---------------TFNFRVDKITTDSASTKE-------TNNIPNHRVLIRPEVQ 312

  Fly   358 ---RFKPLLK--------------KKIGPDSYINTISTQKVPVHQSYEFPTFPSSSAVGSSSSSP 405
               :.|.:.|              :|.|.|..:..|::.|:             :|.:....|.|
Mouse   313 NHQKNKEISKIEEKRALEAERYGFQKDGQDRPLTKINSVKL-------------NSLLSEYESGP 364

  Fly   406 NSLQFPYLRQHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSPPSG--CSTRSASPLDISLSPE 468
            :..  |....:||:....|:|||.:        :.|:..|..|.|:.  .:|.:...:..:.|.:
Mouse   365 DCP--PQNVHYRPINVNSSDGKAVN--------VSLADVRGGSHPNAGPLATEADRVIQRTNSMQ 419

  Fly   469 QHSP----TRGRGV-----GGALQDAVPPGTPTFHGQRPQQRLLKRVGGGAGAGATGGATGSPLV 524
            |...    .:|||:     |......:|...|:...|     :|.|...|.........|....:
Mouse   420 QLEQWIKVQKGRGLEEEPRGVISYQTLPRNMPSHRAQ-----ILARCPEGYRTLPRNSKTRPESI 479

  Fly   525 CPPTPTHH---------ARRHAR------------LQAVTANSSLASGGAIPSDPPAVSSQLDYI 568
            |..|.:.|         .||..|            .|.....|:|...|.: |.|.|:
Mouse   480 CSVTSSGHEKTGPGAEEKRRSMRDDTMWQLYEWQQRQFYHKQSTLPRHGCL-SSPKAM------- 536

  Fly   569 YLQDGGQEQGQEQSDEVVHISSTRLPSIPERSAAAA----------------------------- 604
                      .:.||:.:|    .:|:.|...:|||
Mouse   537 ----------VQVSDQTMH----SIPTSPSHGSAAAYQGFSPQRTYRSEVTSPIQRGDVTIDRRH 587

  Fly   605 ----------AAAAAAAAGAALMEPGTGTVSG----------------SSGAGAAGEPPLPPAWE 643
                      |...:..||..|......::.|                .:...:..|..|....:
Mouse   588 RPHHPKHVYVADRRSMPAGLTLQAVSPQSLQGRTPEELTLLLIKLRRQQAELSSVREHTLAQLMQ 652

  Fly   644 ARMDSHG--RIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRYQSIRRTITNESRAAQL 706
            .::::|.  ......|..|.|.:.              .|..::.:.....:...|.|.:...||
Mouse   653 LKLEAHSPKNEILSHHLQRNTIYL--------------DHQMKENEPIITMVHTMIENSALRPQL 703

  Fly   707 Y----------NLPTSANSNANSTAPAAPPPATAIHPAILMLCRPD------------FYSLLHT 749
            |          :|...:......|.....|....|...:..||..|            .:...:|
Mouse   704 YQQFLRQKNKISLYCLSQDECRGTLYKYRPEEAGIDAKLSRLCEQDKVVRALEEKLQQLHKEKYT 768

  Fly   750 NEAALAIYNRN--------AALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCW-- 804
            .|.||...::.        ||::.:|:         ||......|::.....::.:.||...|
Mouse   769 LEQALLSASQEIEMNADNPAAIQTVVL---------QRDDLQNGLLSTCRELSRATAELERAWRE 824

  Fly   805 ---------------ETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPR---VVRHRQQHSQQQSS 851
                           :.:||:.|     :.|.........::..|..|   |:....:|.||:.|
Mouse   825 YDKLEYDVTVTRDQMQGQLDRLG-----EVQSESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGS 884

  Fly   852 VGYYYPDLVDGNCLSATSGHINASPASSVS----------GVPPLP------------PPRPSSS 894
                          |.|.|...:.|.|||.          ..||||            ||.||.|
Mouse   885 --------------SETVGLAGSKPFSSVKYKSEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDS 935

  Fly   895 SSSSRSSHGHGH 906
            ||....|.|..|
Mouse   936 SSLLCYSRGPVH 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	5/30 (17%)
		HECTc	1068..1424	CDD:238033
		HECTc	1092..1423	CDD:214523
Plekha5	XP_006506926.1	WW	13..42	CDD:366073
		WW	59..88	CDD:366073
		PH_PEPP1_2_3	165..268	CDD:270068	22/119 (18%)
		Smc	<623..>864	CDD:224117	36/268 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900