DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and Wwp1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_796301.2	Gene:	Wwp1 / 107568	MGIID:	1861728	Length:	918	Species:	Mus musculus

Alignment Length:	1328	Identity:	338/1328 - (25%)
Similarity:	499/1328 - (37%)	Gaps:	473/1328 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 ATLSP----TNSYNGSIGSDGGSSVGGGARRKSWTLSPQSGGSTPLSGAKKKTKTGA-------- 213
            ||.||    ::.::|.:......|.....|:|:| ..........:.|..|||...:
Mouse     2 ATASPRSDTSDIHSGRLQLKVTVSSAKLKRKKNW-FGTAIYTEVIVDGEVKKTAKSSSSSNPKWD 65

  Fly   214 --------PTTTLSNANGDGFNLWVARECFETVPAEMVDTLSMAEVDEEVDEEEDEEAAAVESLL 270
                    |.|||.      |.:|                              .......::||
Mouse    66 EQLIVNVTPQTTLE------FRVW------------------------------SHHTLKADALL 94

  Fly   271 GAAAALQASAHVQRRQQQQHHQHLRQPSPPQHRPLERSWPPRAVGRDLKL-----QGDVFQFDIL 330
            |.|..                 .|:|.....:|.||:      |...|||     .|.|...::.
Mouse    95 GKATV-----------------DLKQVLLTHNRKLEK------VKEQLKLSLENKNGIVQTGELT 136

  Fly   331 DTDERLAEEMAQGSGSSNNSPL------------ATPPVRFKPLL--KKKIGPDSYINTISTQKV 381
            ...:.|..|....:..|::.|:            ..|..|..|.|  :..||.|::::|.:.  |
Mouse   137 VVLDGLVIEQEPVTNRSSSPPIEIQQNGDALHENGDPATRTTPRLPVEGTIGIDNHVSTNTV--V 199

  Fly   382 P------VHQSYEFPTFPSSSAVGSSSSSPNSLQFPYLRQHRPLTRALS----NGKASS-SEEQA 435
            |      |......|:.||..|     :.|.:...|     :|:|.|.:    ||::|| ..:..
Mouse   200 PNSCCSHVVNGENTPSSPSQVA-----ARPKNAPAP-----KPVTSAPTSDTVNGESSSVLADNT 254

  Fly   436 SPRLLLSPKRPRSPPSGC--STRSASPLDISLSPEQHS---PTRGRGVGGALQDAVPPGTPTFHG 495
            |....|.|....:..|.|  :|....|:....:..:||   |:....||...:..:.|.:.:.:.
Mouse   255 STMGTLLPSEDTTSTSNCTSTTTQEPPVQEPPASSEHSECIPSASAEVGPEARSLIDPDSDSRNN 319

  Fly   496 QRPQQRLLKRVGGGAGAGATGGATGSPLVCPPTPTHHARRHARLQAVTANSSLASGGAIPSDPPA 560
            .     :..:|....|.       ..||              |.|:...|:.     |:||
Mouse   320 S-----VFDKVRQPEGC-------VEPL--------------RPQSGNTNTE-----ALPS---- 349

  Fly   561 VSSQLDYIYLQDGGQEQGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVS 625
                         |.||.::......::......:..||
Mouse   350 -------------GWEQRKDPHGRTYYVDHNTRTTTWER-------------------------- 375

  Fly   626 GSSGAGAAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDRRY 690
                     ..||||.||.|:|..||::|:||.||||:||||                     ..
Mouse   376 ---------PQPLPPGWERRVDDRGRVYYVDHNTRTTTWQRP---------------------TM 410

  Fly   691 QSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAALA 755
            :|:|.....:|:..||                                            :.|:.
Mouse   411 ESVRNFEQWQSQRNQL--------------------------------------------QGAMQ 431

  Fly   756 IYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDHQ 820
            .:|                   |||.|:..::|..|   .....||..||.::|.:.:.:|::|.
Mouse   432 QFN-------------------QRYLYSASMLAAEN---DPYGPLPPGWEKRVDSTDRVYFVNHN 474

  Fly   821 HRRTSFMDPR---LPVECPR----VVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPAS 878
            .:.|.:.|||   ||.|.|.    .:|:.::      .|.|:    ||
Mouse   475 TKTTQWEDPRTQGLPNEEPLPEGWEIRYTRE------GVRYF----VD----------------- 512

  Fly   879 SVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDV 943
                                       ||..||:                           ::|
Mouse   513 ---------------------------HNTRTTT---------------------------FKD- 522

  Fly   944 PIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQLTILLSLF 1008
                                  .|.|:.::::
Mouse   523 ----------------------PRNGKSSVTK--------------------------------- 532

  Fly  1009 EQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIR 1073
                            |.|.:          .:.|.|..||..|....:|...   |..:|:::.
Mouse   533 ----------------GGPQI----------AYERSFRWKLAHFRYLCQSNAL---PSHVKINVS 568

  Fly  1074 RSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSAN 1138
            |..|.||:|::||:....||:| ||.|::..||||||||.:||:|||||.|:.||.|.||||:..
Mouse   569 RQTLFEDSFQQIMALKPYDLRR-RLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGK 632

  Fly  1139 DTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDN 1203
            :.|.:|::|.|....:...:|.|.||.:.:||.|...:|..|:.||||.:|...:.:.||||:|.
Mouse   633 NNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDT 697

  Fly  1204 EFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRL 1268
            ||:.||.|||||:| ....|.:.|.|..|:||.|...:||.||.||::.|:||.||:..|.:||.
Mouse   698 EFYNSLIWIRDNNI-EECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRF 761

  Fly  1269 ERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIV 1333
            .|||||||::.:.||.||:..:.:..||.:|||:::.|..|:|..||:.||.||. |..|.:.|:
Mouse   762 SRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQII 825

  Fly  1334 WFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNALPRAHTCFNRL 1398
            ||||.::...||.|:|||||||||..:|..||:.|.||.||::|||||.||...|||:|||||||
Mouse   826 WFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRL 890

  Fly  1399 DLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            |||||.:.|.|.||||.|:|||..||.|
Mouse   891 DLPPYKSYEQLKEKLLFAIEETEGFGQE 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	18/28 (64%)
		HECTc	1068..1424	CDD:238033	175/355 (49%)
		HECTc	1092..1423	CDD:214523	167/330 (51%)
Wwp1	NP_796301.2	C2_E3_ubiquitin_ligase	17..140	CDD:175988	29/182 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..182		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..360		39/208 (19%)
		Interaction with ERBB4. /evidence=ECO:0000269\|PubMed:19561640	345..525		67/427 (16%)
		WW	347..376	CDD:278809	7/80 (9%)
		WW	379..408	CDD:278809	18/28 (64%)
		WW	454..483	CDD:278809	8/28 (29%)
		WW	495..524	CDD:238122	10/132 (8%)
		HECTc	564..916	CDD:238033	175/354 (49%)
		HECTc	587..915	CDD:214523	167/330 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810