Protein Alignment CG42797 and YAP1

DIOPT Version :9

• Sequence 1: NP_572574.2
• Gene: CG42797 / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_005271435.1
• Gene: YAP1 / 10413
• HGNCID: 16262
• Length: 510
• Species: Homo sapiens
• Alignment Length: 881
• Identity: 161/881 - (18%)
• Similarity: 233/881 - (26%)
• Gaps: 442/881 - (50%)

  Fly   483 QDAVPPGTPTFHGQRPQQRLLKRVGGGAGAGATGGATGSPLVCPPTPTHHARRHARLQAVTANSS 547
            |...|...|...||.|.|       ...|.|...| .|.|   .|..|.
Human     5 QQPPPQPAPQGQGQPPSQ-------PPQGQGPPSG-PGQP---APAATQ---------------- 42

  Fly   548 LASGGAIPSDPPAVSSQLDYIYLQDGGQEQGQEQSD-----------EVVHISST---RLPSIPE 598
                 |.|..||| ..|:.::        :|..::|           :..::..|   ||..:|:
Human    43 -----AAPQAPPA-GHQIVHV--------RGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPD 93

  Fly   599 --------RSAAAAAAAAAAAAGA-----------------ALMEPG----TGTVSGSSGAGAA- 633
                    :|.:..|:..|..|||                 ..:.||    ||.|||.:....|
Human    94 SFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQ 158

  Fly   634 ----------GEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLDR 688
                      .:.|||..||....|.|:.::::|..:||:||.|
Human   159 HLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDP--------------------- 202

  Fly   689 RYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAA 753
                         |.|.|        |..|.|||.:||
Human   203 -------------RKAML--------SQMNVTAPTSPP--------------------------- 219

  Fly   754 LAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFID 818
                                      .|.|     ::|:   .|..||..||..:.|.|:.::|:
Human   220 --------------------------VQQN-----MMNS---ASGPLPDGWEQAMTQDGEIYYIN 250

  Fly   819 HQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGV 883
            |:::.||::||||.   ||..:...|...|                            ::.|...
Human   251 HKNKTTSWLDPRLD---PRFGKAMNQRISQ----------------------------SAPVKQP 284

  Fly   884 PPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYN 948
            |||.|..|......       |.|.|
Human   285 PPLAPQSPQGGVMG-------GSNSN--------------------------------------- 303

  Fly   949 EKVIAFLRQPNILEILRERQGQHTMSRQLR-EKINILRVEGVPALERLGHDLQLTILLSLFEQEI 1012
                               |.|....:||: ||            ||          |.|.:||:
Human   304 -------------------QQQQMRLQQLQMEK------------ER----------LRLKQQEL 327

  Fly  1013 MGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHL 1077
                 :.:..||....:|   |..|..|  :..|..|||....||..|..|.|      :....:
Human   328 -----LRQVRPQAMRNIN---PSTANSP--KCQELALRSQLPTLEQDGGTQNP------VSSPGM 376

  Fly  1078 LEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYT 1142
            .::.  |.|:.|..|                                   |:.....|.:.|..|
Human   377 SQEL--RTMTTNSSD-----------------------------------PFLNSGTYHSRDEST 404

  Fly  1143 VQVSPLSAF-VDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFH 1206
            .....:|:: |....|.|..|             :|...|..        .:..|.|.|..|.|.
Human   405 DSGLSMSSYSVPRTPDDFLNS-------------VDEMDTGD--------TINQSTLPSQQNRFP 448

  Fly  1207 QSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERG 1271
            ..|:.|.    ||.||||                .|:..|.||
Human   449 DYLEAIP----GTNVDLG----------------TLEGDGMNI---------------------- 471

  Fly  1272 VQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGT 1307
               :.|.|:....|.:.|.:::     ::|.|:|.|
Human   472 ---EGEELMPSLQEALSSDILN-----DMESVLAAT 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	11/28 (39%)
		HECTc	1068..1424	CDD:238033	40/241 (17%)
		HECTc	1092..1423	CDD:214523	37/217 (17%)
YAP1	XP_005271435.1	WW	174..203	CDD:238122	11/62 (18%)
		WW	232..261	CDD:366073	10/28 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900