Protein Alignment Hecw and wwp1

DIOPT Version :10

• Sequence 1: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_073797364.1
• Gene: wwp1 / 103909792
• ZFINID: ZDB-GENE-131120-84
• Length: 885
• Species: Danio rerio
• Alignment Length: 1194
• Identity: 324/1194 - (27%)
• Similarity: 461/1194 - (38%)
• Gaps: 379/1194 - (31%)

  Fly   271 GAAAALQASAHVQRRQQQQHH--------QHLRQPSPPQHRPLE-RSWPPRAVGRD-------LK 319
            |.|..::.::..:.|:..:.|        :.|.....| |.||| |.|...|:..|       |.
Zfish    33 GTAVYVEVTSDGESRKTAKSHCVSSPKWEERLTLNIAP-HAPLEFRVWSHHALKADALLGRAALD 96

  Fly   320 LQGDVFQFD-ILDTDERLAEEMAQGS-GSSNNSPLATPPVRFKPLLKKKIGPDSYINTISTQKVP 382
            |.|.:.:.| .|:....:....|:|. |..:...|..                 :::.:|.....
Zfish    97 LIGTLRKHDGKLENVREVLPLTAEGKHGVVSTGELTV-----------------FLDGLSLDPQL 144

  Fly   383 VHQSYEFPTFPSSSAV-----------GSSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQAS 436
            :|.|    ..|::|.|           ..||:.|         |||.:     || :..:|.:|.
Zfish   145 LHSS----NTPTASKVHQNGDALHEDADDSSARP---------QHRSV-----NG-SDGAENEAP 190

  Fly   437 PRLLLSPKRPRSPPSGCSTRSASPL---DISLSPEQHSPTRGRGVGGALQDAVPPGTPTFHGQRP 498
            |        ..|..|.|   ..|||   |...||...||:             |..||:
Zfish   191 P--------TSSASSEC---RPSPLLNGDRDSSPSHQSPS-------------PKATPS------ 225

  Fly   499 QQRLLKRVGGGAGAGATGGATGSPLVCPPTPTHHARRHARLQAVTANSSLASGGAIPSDPPAVSS 563
                         |.||.....       ||...|...|.:.. .|:.|...|.:..:|.|..||
Zfish   226 -------------AQATPSTQA-------TPPEQASSSAAVNG-EASESACVGESAAADAPCSSS 269

  Fly   564 QLDYIYLQDGGQEQGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSGSS 628
            .                                   |.|..||||...:.|....|...:.....
Zfish   270 S-----------------------------------SPAGGAAAAHTLSAADTHTPAAPSTPAPD 299

  Fly   629 GAGAA------GEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQLD 687
            |...|      |..||||.||.|.|.|||.:|:||.||||:|:||...|.|.
Zfish   300 GGKPAQQQPTGGVEPLPPGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPLGW------------- 351

  Fly   688 RRYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEA 752
                  .|.:.|..|   :|.:    :.|..:|....|...:..:.......|......:|.
Zfish   352 ------ERRVDNRGR---IYYV----DHNTRTTTWQRPTMESVRNFEQWQSQRSQLQGAMHQ--- 400

  Fly   753 ALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFI 817
                :|                   |||.|:..:::..|   .....||..||.::|.:.:.:|:
Zfish   401 ----FN-------------------QRYLYSASMMSAEN---DPLGPLPPGWERRVDTNDRVYFV 439

  Fly   818 DHQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSG 882
            :|..:.|.:.|||                                     |.|..|..
Zfish   440 NHNTKTTQWEDPR-------------------------------------TQGLQNED------- 460

  Fly   883 VPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAY 947
              |||                                                  .|:|   |.|
Zfish   461 --PLP--------------------------------------------------EGWE---IRY 470

  Fly   948 NEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQEI 1012
            ..:.:.:.                                       :.|:.:.|..
Zfish   471 TREGVRYF---------------------------------------VDHNTRTTTF-------- 488

  Fly  1013 MGFVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHL 1077
                    ..|:......::.||.|   :.|.|..||..|....:|.....   .:|:.:.|..|
Zfish   489 --------SDPRTGKSAVTKGPQIA---YERSFRWKLAHFRYLCQSNALAS---HVKITVSRQTL 539

  Fly  1078 LEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYT 1142
            .||:|::||:....||:| ||.|::..||||||||.:||:|||||.|:.||.|.||||:....|.
Zfish   540 FEDSFQQIMNFKPYDLRR-RLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYC 603

  Fly  1143 VQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQ 1207
            :|::|.|....:...:|.|.||.:.:||.|...:|..|:.||||.:|...:.|.||||:|.||:.
Zfish   604 LQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLILKDLESIDPEFYN 668

  Fly  1208 SLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGV 1272
            ||.|||||:| ....|.:.|.|..|:||.:...:||..|.|:.:.|:||:||:..|.:||..|||
Zfish   669 SLIWIRDNNI-EECGLEMFFSVDMEILGKISSHDLKEDGANVQVTEENKEEYIGLMAEWRFSRGV 732

  Fly  1273 QEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQ 1337
            :.||::.:.||.||:..:.:..||.:|||:::.|..|:|..||:.||.||. |..|.:.|:||||
Zfish   733 ESQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLQDWQRNTVYRH-YTRNSKQIIWFWQ 796

  Fly  1338 VIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPP 1402
            :::...||.||||:||||||..:|..||:.|.||.||::|||||.||...|||:|||||||||||
Zfish   797 LVKEVDNEVRLRLMQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPP 861

  Fly  1403 YPTPELLYEKLLLAVEETNTFGIE 1426
            |.:.|.|.||||.|:|||..||.|
Zfish   862 YKSFEQLKEKLLFAIEETEGFGQE 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021	34/153 (22%)
		WW	638..667	CDD:459800	18/28 (64%)
		HECW1_helix	738..794	CDD:465766	8/55 (15%)
		HECTc	1068..1424	CDD:238033	171/355 (48%)
wwp1	XP_073797364.1	None