DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42797 and LOC103909734

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_021325929.1	Gene:	LOC103909734 / 103909734	-ID:	-	Length:	1561	Species:	Danio rerio

Alignment Length:	1544	Identity:	569/1544 - (36%)
Similarity:	755/1544 - (48%)	Gaps:	398/1544 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VPLQPLAASSA--------CLADRSPVDPIAVRLQQE----EQAEGDDEEEE-------EEEEDD 53
            ||:|.|....|        .|..|.|.|.::.:||..    .....||||..       :.|.|.
Zfish   291 VPVQRLLEKHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEVSLNAMPVFDAEPDQ 355

  Fly    54 DDDPKEEEAFYEARNGNESDELEQAFQSALTLTNDVHVSVSEVEEHEPPLASRNQEVAEVEEQQQ 118
            ..||:..|        :.....:...:.||:|      .|.|.....||      |:...::...
Zfish   356 QTDPEPVE--------DPPPASDPPMEDALSL------DVPEPPPECPP------EIEMRDDVDV 400

  Fly   119 QLGACALPQPSEASLTGSKETREPRHHQTLLSTKSCETPANNATLSPTNSYNGSIGSDGGSSVGG 183
            ||.:.:.|         |||| :|...:.:::.:. :||.|:.||..|...:..|..|.|.::
Zfish   401 QLTSLSEP---------SKET-QPEADEEMVTAQG-DTPMNDTTLGETAEQDTGIMGDHGETL-- 452

  Fly   184 GARRKSWTLSPQSGGSTPLSGAKKKTKTGAPTTTLSNANGDGFNLWVARECFETVPAEMVDTLSM 248
                                                            .|.....|:|::|...
Zfish   453 ------------------------------------------------EETMAETPSEVLDNRD- 468

  Fly   249 AEVDEEVDEEEDEEAAAVESLLGAAAALQASAHVQRRQQQQHHQHLRQPSPPQHRPLERSWPPRA 313
            ||..:.|:||.:.|.::.:.
Zfish   469 AEHTDGVNEEHEVETSSEQV--------------------------------------------- 488

  Fly   314 VGRDLKLQGDVFQFDILDTDERLAEEMAQGSGSSNNSPLATPPVRFKPLLKKKIGPDSYINTIST 378
               ||.:.||                         |.  .:|.||.:  ||:|..|.|
Zfish   489 ---DLMVDGD-------------------------NE--CSPRVRVQ--LKRKNRPCS------- 514

  Fly   379 QKVPVHQSYEFPTFPSSSAVGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQASP------ 437
                      .|.....:.:.|:...|.:.:..|:|.|. |..:|.:.:....||:.:|
Zfish   515 ----------LPVSELETVIASTCEEPETPRSHYIRIHH-LLHSLPSAQCHRDEEEDAPDPESSE 568

  Fly   438 RLLLSPKRPRSPPSGCSTRSASPLDISLSPEQHSPTRGRGVGGALQ-DAVPPGTPTFHGQRPQQR 501
            .:.:.|:..:......| .:.||   |:.||...|...|.:..:|. :.:........|:||...
Zfish   569 EITIKPQEDKEDEDEVS-EAQSP---SVVPECPRPCCRRILPRSLSIERLSELNQLLEGERPSPS 629

  Fly   502 LLKRVGGGAGAG----------------------------------ATGGATGSPLVCPPTPTHH 532
            .|:.......:|                                  ...|..|...:|
Zfish   630 TLRIYSEDGDSGRRREPRESECEFCDNSCYSTSCYSTSCYSTSCYSTNSGYEGRNRLC------- 687

  Fly   533 ARRHARLQAVTANSSLASGGAIPSDPPAVSSQLDYIYLQDGGQEQGQEQSDEVVHIS-STRLPSI 596
              .|.||.:|  :|:..|...:.|                 .||:.:|::.....:| |.|.|.:
Zfish   688 --SHTRLSSV--DSTRLSESTVFS-----------------SQEEEEEENSAFESVSDSMRSPDV 731

  Fly   597 PERSAAAAAAAAAAAAGAALMEPGTGTVSGSSGAGAAGEP------------------------- 636
            .|....:.....:::..:.|   |...|..|..||.:..|
Zfish   732 REPGGGSVQWRESSSEESPL---GDAEVDESPVAGPSVRPTGSFHLHCSHHAITQTPALRPDPHH 793

  Fly   637 ------PLPPAWEARMDSHGRIFYIDHTTRTTSWQRP--GAAPSGGPAGREQHHRQQLDRRYQSI 693
                  ||||.||||:|||||:||:||..|||:||||  .|..:|.......|..:||:||||:|
Zfish   794 YPSVDQPLPPNWEARVDSHGRVFYVDHVNRTTTWQRPIHAAKRTGMQRSGSTHQMEQLNRRYQNI 858

  Fly   694 RRTITNE-----SRAAQLYNLPTSANSNANSTAPAAPPPATAIH----------PAILMLCRPDF 743
            :||:.:|     :|.::.....|.:.|...||......|::.::          ||:..:..|:|
Zfish   859 QRTMASEDEPANTRGSERNTGDTESESTTQSTDQRRDGPSSPVNNPNVSQLLQCPAVKFITHPEF 923

  Fly   744 YSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKL 808
            :::||.|..|..::..:..|||||::||||...|:|||:|:|||..:|.||....|||..||.|.
Zfish   924 FTVLHANYGAYRMFTNSTCLKHMVLKIRRDARNFERYQHNRDLVTFINKFADTHLELPRGWEIKT 988

  Fly   809 DQSGKQFFIDHQHRRTSFMDPRLPVECPRVVRH--RQQHSQQQSSVGYYYPDLVDGNCLSATSGH 871
            |..||.||:||..|.|:|||||:|::..|:..|  .:||.|:..|
Zfish   989 DPQGKSFFVDHNSRATTFMDPRIPLQNGRLPNHLIHRQHLQRLRS-------------------- 1033

  Fly   872 INASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGAT 936
            .:|..||.|                           |.:..|         |.....|:.||..:
Zfish  1034 YSAGEASEV---------------------------CRSRGA---------SLVNRTGLVSAVRS 1062

  Fly   937 AAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQL 1001
            ....:.||.|||:|::|||||||||:.|:|||...:.:..|||||:.:|.||...:|:|..|..|
Zfish  1063 QNQPDSVPHAYNDKIVAFLRQPNILDTLQERQPSLSRNHTLREKIHYIRTEGAQGVEKLSCDADL 1127

  Fly  1002 TILLSLFEQEIMGFVPIEE--------------RSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSF 1052
            .:|||||::|||.|||...              .|||.||.|..   .|||.|:|||||||||:|
Zfish  1128 VMLLSLFDEEIMSFVPPHSFHPGLSFSPRCSPGSSPQSSPGLQR---ARAPAPYRRDFEAKLRNF 1189

  Fly  1053 YRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREF 1117
            |||||:|||||||.|:||.:||.||||..|.::|:.::|:|||.:|.:.:..||||||.||||||
Zfish  1190 YRKLEAKGYGQGPGKIKLIVRREHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLDYSGPSREF 1254

  Fly  1118 FFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTR 1182
            |||||:|||||||||||||||||||||:||:||||:|..:|||||||:|||||:|||||||||||
Zfish  1255 FFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTR 1319

  Fly  1183 PFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGK 1247
            |||||||||...|||||.||.||||||||::|||| |.: |.|||.|.||:.|.|.:||||.||.
Zfish  1320 PFYKALLRLVTDLSDLEYLDEEFHQSLQWMKDNDI-TDI-LDLTFTVNEEVFGQVTERELKSGGS 1382

  Fly  1248 NIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDT 1312
            ||.:.|||||:|:|||.:||:||||.:|.|:||||||||:||||||||||||||||||||||||.
Zfish  1383 NIQVTEKNKKDYIERMARWRVERGVMQQAEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDL 1447

  Fly  1313 NDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRF 1377
            :|||.|||||.||||.|.|:.|||..:|||:||||||||||||||||:|||||:|||||.|.|||
Zfish  1448 SDWRSNTEYRGGYHDGHMVMRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRF 1512

  Fly  1378 CIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            |||||||..:|||||||||||||||||:..:||||||.|||||:|||:|
Zfish  1513 CIEKWGKVTSLPRAHTCFNRLDLPPYPSYTMLYEKLLTAVEETSTFGLE 1561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	21/28 (75%)
		HECTc	1068..1424	CDD:238033	264/355 (74%)
		HECTc	1092..1423	CDD:214523	252/330 (76%)
LOC103909734	XP_021325929.1	HECW_N	53..172	CDD:318711
		C2_NEDL1-like	193..329	CDD:176073	11/37 (30%)
		WW	801..830	CDD:306827	21/28 (75%)
		WW	980..1009	CDD:306827	16/28 (57%)
		HECTc	1229..1558	CDD:214523	252/330 (76%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	510	1.000	Domainoid score	I314
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	876	1.000	Inparanoid score	I388
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm26040
orthoMCL	1	0.900	-	-		OOG6_105324
Panther	1	1.100	-	-	O	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1661
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.960