DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and smurf1

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_002931540.1	Gene:	smurf1 / 100491582	XenbaseID:	XB-GENE-479046	Length:	731	Species:	Xenopus tropicalis

Alignment Length:	808	Identity:	242/808 - (29%)
Similarity:	347/808 - (42%)	Gaps:	259/808 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   646 MDSHGRIF-----------YIDHTTRTTSWQRPGAAPSGGPA------GREQHHRQQLDR-RYQS 692
            :|:.|.::           ::|.....|  ..|||| .|||.      |:||  |.|..| |...
Frog   156 LDNDGALYEDAGPGRPLSCFMDEPAPYT--DGPGAA-GGGPCRLVESPGQEQ--RLQAQRLRGPE 215

  Fly   693 IR---RTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSLLHTNEAAL 754
            :|   :|..|.|...|..:||......            |.:...:.         .|||.....
Frog   216 VREHVQTPLNRSHGYQSQDLPEGYEQR------------TTVQGQVY---------FLHTQTGVS 259

  Fly   755 AIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQSGKQFFIDH 819
            ..::         .||.||               |.:........||:.||.:...||:.:|:||
Frog   260 TWHD---------PRIPRD---------------LNSVNCDDLGPLPTGWEVRTTVSGRIYFVDH 300

  Fly   820 QHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLSATSGHINASPASSVSGVP 884
            .:|.|.|.||||    ..::.|:.|..:..:::    |...||                |:....
Frog   301 NNRTTQFTDPRL----HHIINHQSQLKEPNNAI----PVQSDG----------------SLEEGD 341

  Fly   885 PLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNE 949
            ..|..|                                                 ||
Frog   342 EFPTQR-------------------------------------------------YE-------- 349

  Fly   950 KVIAFLRQPNILEILRERQGQHTMSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMG 1014
                                     |.|.:|:.:||           |:|.|.
Frog   350 -------------------------RDLVQKLKVLR-----------HELSLL------------ 366

  Fly  1015 FVPIEERSPQGSPVLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLE 1079
                   .||..                                        ..::.:.|..:.|
Frog   367 -------QPQAG----------------------------------------HCRVEVSREEIFE 384

  Fly  1080 DAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQ 1144
            :::|:||....|||:: ||.|.:..||||||||.:||:.:||..|:.|||||||:||.::.||:|
Frog   385 ESYRQIMKMRPKDLKK-RLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQ 448

  Fly  1145 VSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSL 1209
            ::|.|:...:...:|.|.||::|||:.|.:.::..||.||||.||..|:.||||||:|.|.|:||
Frog   449 INPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSL 513

  Fly  1210 QWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQE 1274
            .||.:|||.:.:|  .||||.....|.::..||||.|||:.:.|:|||||:...:.||..||::.
Frog   514 VWILENDITSVLD--HTFCVEHNAFGRLLQHELKPNGKNLQVTEENKKEYVRLYVNWRFMRGIEA 576

  Fly  1275 QTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRSGYH--DNHQVIVWFWQ 1337
            |..:|.:||.|:|...|:..|:.:||||:|.|..:||.:||:.||..:   |  .|..::.||||
Frog   577 QFLALQKGFNELIPQHLLKPFEQKELELIIGGLDKIDISDWKANTRLK---HCLANSNIVQWFWQ 638

  Fly  1338 VIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGST---GPRRFCIEKW-GKPNALPRAHTCFNRL 1398
            .:|.|..|:|.||||||||::.:|.:||.||:|||   |||.|.|... ...:.||:|||||||:
Frog   639 AVESFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRI 703

  Fly  1399 DLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            |:|||.:.|.||||||.|||||:.|.:|
Frog   704 DIPPYESYEKLYEKLLTAVEETSGFAVE 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	4/31 (13%)
		HECTc	1068..1424	CDD:238033	170/361 (47%)
		HECTc	1092..1423	CDD:214523	164/336 (49%)
smurf1	XP_002931540.1	C2_Smurf-like	14..138	CDD:176028
		WW	234..266	CDD:197736	6/61 (10%)
		WW	280..312	CDD:197736	14/31 (45%)
		HECTc	373..728	CDD:238033	170/360 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000