DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42797 and hecw2b

DIOPT Version :9

Sequence 1:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_003197660.3	Gene:	hecw2b / 100331355	ZFINID:	ZDB-GENE-101001-3	Length:	1472	Species:	Danio rerio

Alignment Length:	1303	Identity:	566/1303 - (43%)
Similarity:	730/1303 - (56%)	Gaps:	264/1303 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 VPAEMVDTLSMAEVDEEVDEEEDEEAAAVESLLGAAA-------------ALQASAHVQRRQQQQ 289
            :|.|.|.......|:...:..||    |:.|||||:|             .||..:.:
Zfish   320 LPTEHVSGQLHFRVEITFNGHED----AMGSLLGASAMNGDPGSPSDDEDVLQPVSRM------- 373

  Fly   290 HHQHLRQPSPPQHRPLERSWPPRAVGRDLKLQGDVFQFD--ILDTDE-RL----AEEMAQGSGSS 347
                :|.|||              .|.:..|.||.|:.|  ::|.:| ||    |.::|:|:.:.
Zfish   374 ----VRGPSP--------------TGSEGSLHGDAFRPDECMMDPEEDRLLRDGAPDLAEGAPAH 420

  Fly   348 NNSPLATPPVRFKPLLKKKIGPDSYINTISTQKVPVHQSYEFPTFPSSSAVGSSSSSPNSLQFPY 412
            .:               ::...:.|::.|           |.|..|....:|:||        |.
Zfish   421 TH---------------RQSSLNDYLDAI-----------EAPKPPGDRPLGASS--------PK 451

  Fly   413 LRQHRPL-TR---------------------ALSNGKA-----SSSEEQASPRLLLSPKRPRSPP 450
            ||...|. ||                     ||:||..     :|||.......:.:.:|..|..
Zfish   452 LRSSFPTDTRLNAMLHIDSDEDEEGHASRDTALTNGMPRPEGHASSERGKGEVHVKNRERLESEA 516

  Fly   451 SGCSTRSASPLDISLSPEQHSPTRGRGVGG----ALQDAVPPGTPTFHGQRPQQRLLKRVGGGAG 511
            :..:|.:.:...:|.|....|...|...||    |:...:.....:|  |:|..|:....|....
Zfish   517 ASSATDTEATASVSSSGTTKSQNGGGAEGGQEGAAISGGLTQSISSF--QQPALRIQDEEGAAPQ 579

  Fly   512 AGA-TGGATGSPLVCPPTPTHHARRHARLQAV-TANSSLASGGAIPSDPPAVSSQLDYIYLQDGG 574
            |.: |.|::.:|.|          ..|...|: |.|.   .|||..::.|.         ..:..
Zfish   580 ASSRTEGSSEAPAV----------SEASASAIYTVNE---VGGATATNQPE---------RMNSS 622

  Fly   575 QEQGQEQSDEVVHISSTRLPSIPERSAAAA------AAAAAAAAGAALMEPG-TGTVSGSSGAGA 632
            :...||:.||.:......|.:....|.|.|      ....|..|.|||:..| ||..:..:|
Zfish   623 EMTNQEEEDEEIWQRRRSLQASGNESQAEAMELGNEVRRTADEAQAALITDGETGACAQVNG--- 684

  Fly   633 AGEP-------------------PLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGR 678
             .:|                   ||||.||||:||||||||:||..|||:||||.|.|:.....|
Zfish   685 -HQPMRSLPSVRHDISRYQRVDEPLPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQR 748

  Fly   679 EQHHRQ--QLDRRYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPP--------PATA--- 730
            ....:|  ||:|||||||||||||....|...:|....:.::....:.|.        ||::
Zfish   749 SNSIQQMEQLNRRYQSIRRTITNERTEEQAAEMPPDDLTTSDLLHHSIPEYRRDGVVGPASSRSR 813

  Fly   731 -----IHPAILMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALV 790
                 ..|:...|..|||:::||:|.:|..::..|..||||:.::|||...|:|||:|:||||.:
Zfish   814 LTLLLQSPSAKFLTSPDFFTVLHSNPSAYRMFTSNTCLKHMISKVRRDAHHFERYQHNRDLVAFL 878

  Fly   791 NTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPR---VVRHRQQHSQQQSSV 852
            |.||....:||..||.|.|.:||.||:||..|.|:|:|||||::..|   ::.|||..|:|:|.
Zfish   879 NMFANKQLDLPRGWEMKHDHTGKPFFVDHNCRATTFIDPRLPLQSARPSSLLAHRQHLSRQRSH- 942

  Fly   853 GYYYPDLVDGNCLSATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCA 917
                           ::|.:...|..:    .|...||||::.:::|      :.|.
Zfish   943 ---------------SAGEVGDDPRHA----GPAVLPRPSNTFTANR------NQCQ-------- 974

  Fly   918 LNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQLREKIN 982
                                   :.||:|||||::||||||||.:||:|||.:...:..||||:.
Zfish   975 -----------------------DLVPVAYNEKIVAFLRQPNIFDILQERQPELIRNHSLREKVQ 1016

  Fly   983 ILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEE-------RSPQGSPVLN-------SRM 1033
            .:|.||...|.||..|..|.|||||||:|:|.:||...       :||:||||.:       .|.
Zfish  1017 FIRNEGASGLARLSSDADLVILLSLFEEEVMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRA 1081

  Fly  1034 PQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRL 1098
            ..|||.|::||||||||:||||||:|||||||.|:||.|||.|||||||.:||..::|||||.:|
Zfish  1082 NARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKVKLIIRRDHLLEDAFNQIMCYSRKDLQRSKL 1146

  Fly  1099 AVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSG 1163
            .|.:..||||||.|||||||||:|||||||||||||||||||||||:||:||||||.|:||||||
Zfish  1147 YVSFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSG 1211

  Fly  1164 RVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFC 1228
            |:|||||:|||||||||||||||.|||:|..|||||.||.||||||||::||||...:|  |||.
Zfish  1212 RILGLALIHQYLLDAFFTRPFYKGLLRIPCDLSDLEYLDEEFHQSLQWMKDNDIEDMLD--LTFT 1274

  Fly  1229 VTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVS 1293
            |.||:.|.:.:|||||||.||.::|||||||:|||:|||:||||.:||||||||||||:|:||||
Zfish  1275 VNEEVFGQITERELKPGGANIPVSEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVS 1339

  Fly  1294 VFDARELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTS 1358
            ||||||||||||||||||..|||.|||||.||||||.||.|||..:|||:|||||||||||||||
Zfish  1340 VFDARELELVIAGTAEIDLGDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTS 1404

  Fly  1359 SIPYEGFSALRGSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTF 1423
            |||||||::||||.||||||:|||||..:|||||||||||||||||:..:||||:|.|||||:||
Zfish  1405 SIPYEGFASLRGSNGPRRFCVEKWGKITSLPRAHTCFNRLDLPPYPSFSMLYEKMLTAVEETSTF 1469

  Fly  1424 GIE 1426
            |:|
Zfish  1470 GLE 1472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42797	NP_572574.2	WW	638..667	CDD:278809	22/28 (79%)
		HECTc	1068..1424	CDD:238033	274/355 (77%)
		HECTc	1092..1423	CDD:214523	258/330 (78%)
hecw2b	XP_003197660.3	HECW_N	58..177	CDD:318711
		C2_NEDL1-like	198..334	CDD:176073	3/13 (23%)
		LGT	<491..633	CDD:320995	34/165 (21%)
		WW	708..737	CDD:306827	22/28 (79%)
		WW	887..919	CDD:197736	17/31 (55%)
		HECTc	1117..1470	CDD:238033	274/354 (77%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5820
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940