Protein Alignment Hecw and itchb

DIOPT Version :10

• Sequence 1: NP_572574.2
• Gene: Hecw / 31905
• FlyBaseID: FBgn0261931
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_073794034.1
• Gene: itchb / 100330031
• ZFINID: ZDB-GENE-131024-2
• Length: 871
• Species: Danio rerio
• Alignment Length: 1168
• Identity: 325/1168 - (27%)
• Similarity: 464/1168 - (39%)
• Gaps: 412/1168 - (35%)

  Fly   300 PQHRPLERSWPPRAVGRDLKLQGDVFQFDILDT----DERLAE--EMAQGSGSSNNSPLATPPVR 358
            |..:.:.|.|..:.:..||.|  .|...||.:|    |.::.|  :..|......:..:....|.
Zfish    75 PFSKLIFRVWSHQTLKSDLLL--GVATLDISETLKSHDMKICEVVQTLQLCDRDQSDSIGDLSVC 137

  Fly   359 FKPLLKKKIGPDSYINTISTQKVPVHQSYEFPTFPSSSAVGSSSS-----SPNSLQFPYLRQHRP 418
            ...|   ::.|:.:.:..::     :||....|....|.:...|.     ||:..:    .|.||
Zfish   138 LDGL---QVDPEMFQSAEAS-----NQSQSLNTLNGESELNEDSGRSRDPSPSVSE----GQDRP 190

  Fly   419 LTRALSNGK----------ASSSEEQASPRLLLSPKR-----PRSPPSGCSTRSASPLDISLSPE 468
               |..||:          |.||..|..||    |.|     ||.|.|..::.:.|..|.|.|..
Zfish   191 ---AAPNGRVNGLDSPSVSARSSRAQRPPR----PSRPPPPTPRRPTSSPASSTGSFPDGSDSSR 248

  Fly   469 QHSPTRGRGVGGALQDAVPPGTPTFHGQRPQQRLLKRVGGGAGAGATGGATGSPLVCPPTPTHHA 533
            ..:|.| ...||...|:.|  .||.  ::|.:..|.                   || |||
Zfish   249 SDTPVR-NPTGGGASDSSP--APTV--EQPGRTALS-------------------VC-PTP---- 284

  Fly   534 RRHARLQAVTANSSLASGGAIPSDPPAVSSQLDYIYLQDGGQEQGQEQSDE---VVHISSTRLPS 595
               :|:      .|:.:.|.:|.                 |.||..:|:..   |.|:.......
Zfish   285 ---SRI------PSMVNAGPLPP-----------------GWEQRVDQNGRLYFVDHVEKRTTWE 323

  Fly   596 IPERSAAAAAAAAAAAAGAALMEPGTGTVSGSSGAGAAGEPPLPPAWEARMDSHGRIFYIDHTTR 660
            .||                                      |||..||.|:|..||::::||.||
Zfish   324 RPE--------------------------------------PLPSGWERRVDPMGRVYFVDHITR 350

  Fly   661 TTSWQRPGAAPSGGPAGREQHHRQQLDRRYQSIRRTITNESRAAQLYNLPTSANSNANST-APAA 724
            ||:|||| ...:.....:.||.|.||....|...:..        :..|...|::..|.. .|..
Zfish   351 TTTWQRP-TMETVRNYEQWQHQRSQLQGAMQQFNQRF--------IIGLQDQASATQNKEFDPLG 406

  Fly   725 PPPATAIHPAILMLCRPDFYSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVAL 789
            |
Zfish   407 P---------------------------------------------------------------- 407

  Fly   790 VNTFAQMSRELPSCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGY 854
                      ||..||.:.|.:|:.:|:.|..|.|.:.|||
Zfish   408 ----------LPHGWEKRTDSNGRVYFVHHPTRSTQWEDPR------------------------ 438

  Fly   855 YYPDLVDGNCLSATSGHINASPAS-------SVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTS 912
                         |.|.:|..|..       :|.|:|                 :...||..||:
Zfish   439 -------------TQGLLNEKPLPEGWEMRFTVDGIP-----------------YFVDHNRRTTT 473

  Fly   913 AISCALNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSRQL 977
            .|.                                                  .|.|:.::
Zfish   474 YID--------------------------------------------------PRTGKSSL---- 484

  Fly   978 REKINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRMPQRAPPPFR 1042
                                                      |..||.:.|
Zfish   485 ------------------------------------------ENGPQITYV-------------- 493

  Fly  1043 RDFEAKLRSF---YRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDT 1104
            |||:||::.|   .::|..      |..:|:::.|..|.||:|::|||.:.:||:| ||.:::..
Zfish   494 RDFKAKVQYFRFWCQQLSM------PQHIKINVSRKTLFEDSFQQIMSFSAQDLRR-RLWIIFPG 551

  Fly  1105 EEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCH-DWFRFSGRVLGL 1168
            ||||||||.:||:|||||.|:.||.|.||||:..|.|.:|::|.| :::..| .:|:|.||.:.:
Zfish   552 EEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPAS-YINPDHLKYFKFIGRFIAM 615

  Fly  1169 ALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIRDNDIGTGVDLGLTFCVTEEL 1233
            ||.|...:|..|:.||||.:|..|:.|.||||:|.||:.||.||:||:| ....|.:.|.|.:|:
Zfish   616 ALFHGKFIDTGFSLPFYKRILNKPLTLKDLESIDPEFYNSLIWIKDNNI-EECGLEMFFSVDKEI 679

  Fly  1234 LGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDAR 1298
            ||.|...||||.|.||.:.|:||:||:..:.:|||.|||:|||::...||.||:..:.:..|||:
Zfish   680 LGEVSTHELKPDGGNIQVTEENKEEYIRLVAEWRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAK 744

  Fly  1299 ELELVIAGTAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYE 1363
            |||:::.|..|||.|||:.||.||. |..:.:.|:||||.|:...||:|:|||||||||..:|..
Zfish   745 ELEVMLCGMQEIDLNDWQRNTIYRH-YTSSSKQIMWFWQFIKEMDNEKRMRLLQFVTGTCRLPVG 808

  Fly  1364 GFSALRGSTGPRRFCIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE 1426
            ||:.|.||.||::|||||.||.|.|||:||||||||||||.:.|.|.|||:.|:|||..||.|
Zfish   809 GFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYRSYEQLKEKLMFAIEETEGFGQE 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hecw	NP_572574.2	PHA03247	<411..562	CDD:223021	41/165 (25%)
		WW	638..667	CDD:459800	16/28 (57%)
		HECW1_helix	738..794	CDD:465766	0/55 (0%)
		HECTc	1068..1424	CDD:238033	181/356 (51%)
itchb	XP_073794034.1	None